The major histocompatibility complex (Mhc) is one of the few identified gene systems in domestic animals that is associated with quantitative traits such as disease resistance, immune response, growth, and reproduction. As knowledge of this important system increases, we move closer toward the reality of genetic enhancement of animal welfare and production efficiency. This book represents the current state of knowledge on the Mhc of agriculturally important animals and explores the latest advances in technology. For the first time, the unique findings of recent Mhc research are presented in a single source.
The Major Histocompatibility Complex Region of Domestic Animal Species begins with a discussion of the evolution of Mhc. The chapters are then organized with respect to specific species, with a chapter devoted to each. The Mhc of mice and humans are used as a common reference for comparisons between diverse species. The text concludes with a look at future strategies and directions in Mhc research. Comparative immunologists and geneticists, veterinarians, animal breeders, researchers, and university and postgraduate students will all benefit from this detailed look at the evolution, structure, and organization of Mhc.
Table of Contents
Major Histocompatibility Complex Evolution, L. Andersson
The Major Histocompatibility Complex of Fish: Genetic Structure and Function of the Mhc of Teleost Species, O. Lie and U. Grimholt
The Chicken Major Histocompatibility Complex, J.F. Kaufman and S.J. Lamont
Genetic Organization, Polymorphism, and Function of the Bovine Major Histocompatibility Complex, H.A. Lewin
The Caprine Major Histocompatibility Complex, G. Obexer-Ruff, I. Joosten, and F.-W. Schwaiger
The Ovine Major Histocompatibility Complex, F.-W. Schwaiger, J. Maddox, K. Ballingall, J. Buitkamp, A.M. Crawford, B.M. Dutia, J. T. Epplen, E.D. Ferguson, D. Groth, J. Hopkins, S.M. Rhind, D. Sargan, J. Wetherall, and H. Wright
The Cervine Major Histocompatibility Complex: Genetic Structure and Function of the Cervine DRB Genes, P.A. Swarbrick and A.M. Crawford
The Canine Major Histocompatibility Complex: Genetic Structure and Function of the Mhc of Dogs, U.M. Sarmiento
The Swine Major Histocompatibility Complex, L.B. Schook, M.S. Rutherford, J.-K. Lee, Y.-C. Shia, M. Bradshaw, and J.K. Lunney
The Equine Major Histocompatibility Complex, E. Marti, G. Szalai, D.F. Antczak, E. Bailey, H. Gerber, and S. Lazary
The Major Histocompatibility Complex of the Rabbit, N. Sittisombut
Future Perspectives, L.B. Schook and S.J. Lamont