The Organic Chemistry of Sugars: 1st Edition (Hardback) book cover

The Organic Chemistry of Sugars

1st Edition

Edited by Daniel E. Levy, Péter Fügedi

CRC Press

904 pages | 881 B/W Illus.

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pub: 2005-09-21
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Description

Intrigued as much by its complex nature as by its outsider status in traditional organic chemistry, the editors of The Organic Chemistry of Sugars compile a groundbreaking resource in carbohydrate chemistry that illustrates the ease at which sugars can be manipulated in a variety of organic reactions.

Each chapter contains numerous examples demonstrating the methods and strategies that apply mainstream organic chemistry to the chemical modification of sugars. The book first describes the discovery, development, and impact of carbohydrates, followed by a discussion of protecting group strategies, glycosylation techniques, and oligosaccharide syntheses. Several chapters focus on reactions that convert sugars and carbohydrates to non-carbohydrate molecules including the substitution of sugar hydroxyl groups to new groups of synthetic or biological interest, cyclitols and carbasugars, as well as endocyclic heteroatom substitutions. Subsequent chapters demonstrate the use of sugars in chiral catalysis, their roles as convenient starting materials for complex syntheses involving multiple stereogenic centers, and syntheses for monosaccharides. The final chapters focus on new and emerging technologies, including approaches to combinatorial carbohydrate chemistry, the biological importance and chemical synthesis of glycopeptides, and the medicinally significant concept of glycomimetics.

Presenting the organic chemistry of sugars as a solution to many complex synthetic challenges, The Organic Chemistry of Sugars provides a comprehensive treatment of the manipulation of sugars and their importance in mainstream organic chemistry.

Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.

Reviews

Although almost every author notes that his or her chapter is not an exhaustive analysis, each does provide an excellent, broad scope of what has been done and what is possible to do within the subfield. A must for both synthetic organic and carbohydrate chemists…Highly recommended.”

—L.J. Liotta, CHOICE, April 2006

“The title, The Organic Chemistry of Sugars, is very appropriate and is unique among reference works in that regard. …The book…will prove indispensable to the practicing carbohydrate chemist and any organic chemist who chooses to delve into the synthesis of carbohydrate compounds.”

—David C. Baker, Journal of the American Chemical Society, Vol. 128, No. 42, 2006

“Numerous examples throughout the volume provide excellent illustrative material to support the detailed information presented in the text. In conclusion, this comprehensive volume would be highly useful to all persons working in this area. It may not only support research and development but also be suitable for teaching.”

— Parmjit S. Panesar, Chembiotech Laboratories, University of Birmingham, UK in Carbohydrate Polymers, Vol. 64, 2006

“Each chapter starts with an introduction that allows nonspecialists to also find a way of approaching the subject. …The contributions, all written by well-known researchers, are well coordinated with each other and cover most aspects of synthetic sugar chemistry. …The content of the book is easily accessible through the detailed table of contents as well as the index. …The book is highly recommended for the carbohydrate chemist [as well as] those wishing to become one.”

— Valentin Wittmann, University of Konstanz, Germany, in Angewandte Chemie, Vol. 45, No. 21, May 2006

“…chapters on ‘Sugars as Starting Materials in Synthesis’ and Asymmetric Synthesis of Monosaccharides’ are well worth reading. …Overall, this is an excellent compendium…”

Organic Process Research & Development

“…Provides a comprehensive treatment of the manipulation of sugars and their importance in organic chemistry.”

International Food Information Service

“This 870-page book exclusively addresses the synthetic aspects of carbohydrate chemistry and is a must for any practicing carbohydrate chemist as central source of reading and reading material. …one of the most readable and comprehensive volumes on synthetic carbohydrate chemistry that I have read. The fact that it pays due attention to the application(s) of carbohydrates in mainstream organic synthesis also makes it a valuable resource for the more classical synthetic organic chemist.”

— Biochemist e-volution

“ The Organic Chemistry of Sugars provides excellent coverage of traditional and contemporary methods to manipulate, use, and exploit sugar molecules. With the availability of this monograph, the knowledge base of modern carbohydrate chemistry will be considerably richer for the practitioners of this time-revered and venerable branch of organic chemistry."

— Stephen Hanessian, from the Foreword

“The well-made monograph has a clear textbook style, and all chapters are balanced in their contents. It covers the basics as well as the cutting-edge developments in the chemistry of sugars … it addresses a broad community of scientists, from graduate students to more established researchers. … The book was very carefully made: because of the large index, the reader will have no problem in finding a specific subject; the schemes are clearly arranged, and the numbering is systematic; … this monograph provides an excellent entry over the recent developments as well as frontiers in organic sugar chemistry. For the interested scientist working in these areas and for the synthetically oriented chemist, it will be a compulsory reading. Therefore, this valuable book will have its definite place in every good scientific library.”

—Siegfried R. Waldvogel, Universitat Bonn, Germany, in Synthesis, No. 3, pp 484-484, 2007

Table of Contents

A DISCUSSION OF CARBOHYDRATE CHEMISTRY

An Historical Overview; R.J. Ferrier

Introduction to Carbohydrates; J. Kuszmann

Protective Group Strategies; S. Oscarson

Glycosylation Methods; P. Fügedi

Oligosaccharide Synthesis; P. Fügedi

FROM SUGARS TO SUGAR-LIKE STRUCTURES TO NON-SUGARS

Functionalization of Sugars; D.E. Levy

Strategies Towards C-Glycosides; D.E. Levy

From Sugars to Carba-Sugars; M. Sollogoub and P. Sinaÿ

Sugars with Endocyclic Heteroatoms Other than Oxygen; P. Greimel, J. Spreitz, F.K. Sprenger, A.E. Stütz, and T.M. Wrodnigg

SUGARS AS TOOLS, CHIRAL POOL STARTING MATERIALS AND FORMIDABLE SYNTHETIC TARGETS

Sugars as Chiral Auxiliaries; N. Pleuss, G. Zech, B. Furman, and H. Kunz

Sugars as Chiral Starting Materials in Enantiospecific Synthesis; Y. Chapleur and F. Chrétien

Synthesis of Carbohydrate Containing Complex Natural Compounds; K. Toshima

Total Asymmetric Synthesis of Monosaccharides and Analogs; P. Vogel

ADDITIONAL TOPICS

Combinatorial Carbohydrate Chemistry; P. Arya and B. VNBS Sarma

Glycopeptides; M. Mogemark, J. Kihlberg

Carbohydrate Mimetics in Drug Discovery; O. Schwardt, H.C. Kolb, and B. Ernst

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
SCI013000
SCIENCE / Chemistry / General
SCI013040
SCIENCE / Chemistry / Organic