The Physics of Modern Brachytherapy for Oncology: 1st Edition (Hardback) book cover

The Physics of Modern Brachytherapy for Oncology

1st Edition

By Dimos Baltas, Loukas Sakelliou, Nikolaos Zamboglou

CRC Press

647 pages | 189 B/W Illus.

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Description

Brachytherapy has become the modality of choice for several cancer localizations, minimizing the possibility of unacceptable risks for healthy tissues and providing a more cost-effective and convenient treatment for patients. Written by leading experts in the physics, development, and implementation of brachytherapy, The Physics of Modern Brachytherapy for Oncology discusses the subject in detail, covering its definition, the basic physics of radiation interaction with matter, radionuclides, sources and source production, calibration and dosimetry protocols as well as experimental dosimetry methods appropriate for practical use.

Logically organized, the book begins with basic information, including quantities and units, followed by fundamental atomic and nuclear physics. It also provides the historical background of brachytherapy physics. The next several chapters discuss the radionuclides used in brachytherapy, reflecting upon past (radium), present (iridium or cobalt), and future (ytterbium) methods. The book proceeds to examine source calibration and dosimetry protocols for dose rate calculation while the final chapters explore more recent processes, including Monte Carlo-aided, experimental, and gel dosimetry. The appendices provide useful tables of isotopes, unit conversions and physical constants, brachytherapy sources, TG-43 and TG-43 U1 data tables, and dose rate tables.

Detailing the physics behind brachytherapy treatment, The Physics of Modern Brachytherapy for Oncology is essential reading for researchers, practicing radiation oncologists, and medical physicists who want to keep abreast of the developments in this changing field as well as for postgraduate students in medical physics.

Reviews

"Detailing the physics behind brachytherapy treatment, this book is essential reading for researchers, practicing radiation oncologists, and medical physicists who want to keep abreast of the developments in this changing field as well as for postgraduate students in medical physics."

–In Anticancer Research, Nov-Dec 2008, Vol. 28, No. 6B

Table of Contents

THE EARLY HISTORY OF BRACHYTHERAPY PHYSICS

Introduction

Discoveries

Ionization and X-Rays

a, ß, ?, and Half-Life

Nuclear Transformation

Rutherford-Bohr Atom

The Start of Brachytherapy

Dose Rates

Dosimetry Systems

Marie Curie

RADIATION QUANTITIES AND UNITS

Introduction

Ionization and Excitation

Radiometry

Interaction Coefficients

Dosimetry

Radioactivity

ATOMS, NUCLEI, ELEMENTARY PARTICLES, AND RADIATIONS

Atoms

Atomic Nucleus

Nuclear Transformation Processes

Modes of Decay

Elementary Particles and the Standard Model

INTERACTION PROPERTIES OF PHOTONS AND ELECTRONS

Introduction

Photon Interaction Processes

Mass Attenuation Coefficient

Mass Energy Absorption Coefficients

Electron Interaction Processes

BRACHYTHERAPY RADIONUCLIDES AND THEIR PROPERTIES

Introduction

Notation

60Cobalt

137Caesium

198Gold

192Iridium

125Iodine

103Palladium

169Ytterbium

170Thullium

PRODUCTION AND CONSTRUCTION OF SEALED SOURCES

Introduction

192Iridium Sources

125Iodine LDR Seeds

103Palladium LDR Seeds

169Ytterbium LDR Seeds

60Cobalt HDR Sources

137Cesium LDR Sources

198Gold HDR Seeds

170Thulium High Activity Seeds

131Caesium LDR Seeds

Enrichment Methods

ß-ray Emitting Microparticles and Nanoparticles

SOURCE SPECIFICATION AND SOURCE CALIBRATION

Source Specification

Source Calibration

SOURCE DOSIMETRY

Introduction

Coordinate Systems and Geometry Definition

Models of Dose Rate and Dose Calculation

MONTE CARLO-BASED SOURCE DOSIMETRY

Introduction

Monte Carlo Photon Transport Simulations

Monte Carlo-Based Dosimetry of Monoenergetic Photon Point Sources

Monte Carlo-Based Dosimetry of 103Pd, 125I, 169Yb, and 192Ir Point Sources

Monte Carlo-Based Dosimetry of Commercially Available 192Ir Source Designs

Monte Carlo-Based Dosimetry of 125I and 103Pd LDR Seeds

EXPERIMENTAL DOSIMETRY

Introduction

Phantom Material

Ionization Dosimetry

TLD Dosimetry

Polymer Gel Dosimetry in Brachytherapy

Appendix 1 Data Table of the Isotopes

Appendix 2: Unit Conversion Factors and Physical Constants

Appendix 3: TG-43 Tables for Brachytherapy Sources

Appendix 4: Dose Rate Tables for Brachytherapy Sources

Index

*Each chapter contains references.

About the Series

Series in Medical Physics and Biomedical Engineering

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Subject Categories

BISAC Subject Codes/Headings:
MED062000
MEDICAL / Oncology
SCI055000
SCIENCE / Physics