1st Edition

The Physiological Basis of Metabolic Bone Disease

    232 Pages 27 B/W Illustrations
    by CRC Press

    232 Pages 27 B/W Illustrations
    by CRC Press

    Research into metabolic bone disease has made remarkable progress over the last 20 years, with the identification of numerous new molecules and pathways regulating bone cells as well as their plasma milieu. Their activities are largely regulated by the physiological status of the body incorporating the biochemical, physical and mechanical functions of bone, kidney and intestinal tissues. The Physiological Basis of Metabolic Bone Disease integrates the knowledge derived from molecular techniques with the fundamental principles of the physiology of these organs.

    The book places particular emphasis on bone cell activities and the regulation of plasma calcium, phosphate homeostasis, and whole body nutrition. It reviews the nutritional requirements for calcium and vitamin D for the prevention of osteoporosis. It covers vitamin D, calcium and phosphate absorption; calcium sensing receptors; the role of parathyroid hormone; physiological actions of calcitonin; and the diagnosis and significance of osteoporosis. Reviewing the physiological significance of advances in the molecular biology of metabolic bone disease, this book provides a valuable reference for researchers as well as practicing clinicians.

    Nutritional Requirements for Calcium and Vitamin D
    J. Christopher Gallagher

    Physiology of Vitamin D, Calcium, and Phosphate Absorption
    James C. Fleet and Munro Peacock

    Plasma and Extracellular Fluid Calcium Homeostasis in Relation to Metabolic Bone Disease: Role of Kidneys
    Richard L. Prince

    Calcium Sensing Receptors: Coordinators of Mineral Metabolism and Therapeutic Targets for Metabolic Bone Disorders
    Arthur D. Conigrave

    Parathyroid Hormone: Its Role in Calcium and Phosphate Homeostasis
    David Goltzman

    Phosphate Homeostasis and Metabolic Bone Disease
    Farzana Perwad and Anthony A. Portale

    Vitamin D: Activities for Bone Health
    Howard A. Morris, Paul H. Anderson, and B.E. Christopher Nordin

    Physiological Actions of Calcitonin
    Rachel A. Davey and David M. Findlay

    Definition, Diagnosis, and Significance of Osteoporosis
    B.E. Christopher Nordin and Richard L. Prince


    Borje Edgar Christopher Nordin, Howard Arthur Morris, Paul Anderson