The area of polyamines is presented in this useful, two-volume publication. Basic information describing the role of polyamines in the processes of growth and differentiation is given. Also included are data on the regulation of polyamine biosynthesis and metabolism and their interactions with nucleic acids. Several chapters are devoted to the role of polyamines in various aspects of plant biology, with a special emphasis on their participation in the response of plants to extreme environments. Special attention is given to the use of inhibitors of polyamine biosynthesis as potential antitumor and antiproliferative agents. Additionally, progress in the molecular biology and genetic engineering of genes coding for polyamine biosynthetic enzymes is described. Cancer researchers, biologists, geneticists, biochemists, physiologists, and clinicians will find this volume indispensable.
VOLUME I: PHYSIOLOGICAL FUNCTION OF POLYAMINES. Polyamines and Steroid Sex Hormone Action. Polyamines and Human Reproduction. Polyamines and Heart Physiology. Polyamines, Hormone Receptors, and Calcium Fluxes. Polyamines and Cell Differentiation. Polyamines in Tissue Regeneration. POLYAMINES AND THE STRUCTURE OF NUCLEIC ACIDS. Specificity and Binding in Polyamine/Nucleic Acid Interactions. Polyamines and Initiation of Protein Synthesis in Eukaryotes. Polyamines and RNA Synthesis. Effects of Polyamines and Antibiotics on the Structure and Function of Ribosomes. POLYAMINE METABOLISM. Acetylation and Interconversion of the Polyamines. Oxidation of Diamines and Polyamines. Polyamine Oxidases and Oxidized Polyamines. 5'-Deoxy-5'-Methylthioadenosine: Novel Metabolic and Physiological Aspects. ORNITHINE AND S-ADENOSYLMETHIONINE DECARBOXYLASES. The Physiological Significance of Ornithine Decarboxylase. Molecular Genetics of Mammalian Ornithine Decarboxylase. The Molecular Biology of Mouse Ornithine Decarboxylase. Inhibitors of Ornithine and S-Adenosylmethionine Decarboxylases. The Roles of Antizyme in the Regulation of Ornithine Decarboxylase Activity in Eukaryotic Cells. S-Adenosylmethionine Decarboxylase: Genes and Expression. Index.