1st Edition

The Road from Nanomedicine to Precision Medicine

    1284 Pages
    by Jenny Stanford Publishing

    The enormous advances in nanomedicine and precision medicine in the past two decades necessitated this comprehensive reference, which can be relied upon by researchers, clinicians, pharmaceutical scientists, regulators, policymakers, and lawyers alike. This standalone, full-color resource broadly surveys innovative technologies and advances pertaining to nanomedicine and precision medicine. In addition, it addresses often-neglected yet crucial areas such as translational medicine, intellectual property law, ethics, policy, FDA regulatory issues, nano-nomenclature, and artificial nano-machines—all accomplished in a user-friendly, broad yet interconnected format. The book is essential reading for the novice and the expert alike in diverse fields such as medicine, law, pharmacy, genomics, biomedical sciences, ethics, and regulatory science. The book’s multidisciplinary approach will attract a global audience and serve as a valuable reference resource for industry, academia, and government.

    PART A

    Drug Delivery at the Nanoscale: A Guide for Scientists, Physicians and Lawyers
    Raj Bawa, MS, PhD

    What Is Precision Medicine? A Primer on Contemporary Issues and Concerns
    Kadija Ferryman, PhD, and Mikaela Pitcan, PhD

    FDA’s Role in Paving the Way for Personalized Medicine
    U.S. Food and Drug Administration

    Multifunctional Gold Nanoparticles in Drug Delivery Systems
    Zachary I. Stryker, Mehdi Rajabi, PhD, and Shaker A. Mousa, PhD

    Nanoparticles and Nanoparticulate Drug Delivery Systems: Impact of Size and Structure on Functionality
    Ajit S. Narang, PhD, Rong-Kun Chang, PhD, and Munir A. Hussain, PhD

    Self-Assembling Peptide Amphiphiles as a Versatile Future Nanomedicine Platform
    Run Chang, MS, and Thomas J. Webster, PhD

    Pharmaceutical Applications of Water-Soluble Polymers in Nanomedicine and Drug Delivery
    Schuyler A Pruyn, BSc, Mehdi Rajabi, PhD, Mary Adeyeye, BSc, and Shaker A. Mousa, PhD

    Nanomaterials: Tools, Technology, and Methodology of Nanotechnology-Based Biomedical Systems for Diagnostics and Therapy
    Christian Schmidt, PhD, and Joachim Storsberg, PhD

    Nanomagnetic Resonance Imaging (Nano-MRI) Gives Personalized Medicine a New Perspective
    Lorenzo Rosa, PhD, Jonathan Blackledge, and Albert Boretti, PhD

    Advancing Precision Medicine: Tailoring Personalized Therapies
    Kyle B. Matchett, PhD, Niamh Lynam-Lennon, PhD, R. William Watson, PhD, and James A. L. Brown, PhD

    Precision Medicine for Alzheimer’s Disease Prevention
    Cara L. Berkowitz, BA, Lisa Mosconi, PhD, Olivia Scheyer, BA, Aneela Rahman, BA, Hollie Hristov, FNP, and Richard S. Isaacson, MD

    Advanced Porphyrin Nanomaterials for Biological Applications
    Haoyuan Huang, PhD, and Jonathan F. Lovell, PhD

    Cerium Oxide Nanoparticles as a Novel Reactive Oxygen Modulating Nanodrug
    Ece Alpaslan, PhD, and Thomas J. Webster, PhD

    Artificial Nanomachines and Nanorobotics
    Alexandre Loukanov, PhD, DSc, Hristo Gagov, PhD, and Seiichiro Nakabayashi, PhD

    Nanomotors for Nucleic Acid, Protein, Pollutant, and Cell Detection
    Alejandro Baeza, PhD, and María Vallet-Regí, PhD

    Magneto-Responsive Scaffolds for Tissue Engineering Applications
    Adedokun A. Adedoyin, PhD, and Adam K. Ekenseair, PhD

    Anti-Cancer and Anti-Angiogenic Properties of Nano-Diamino-Tetrac, A Thyroid Hormone Derivative
    Paul J. Davis, MD, and Shaker A. Mousa, MBA, PhD

    PART B

    Proteomic Profiling and Predictive Biomarkers in Neuro-Traumatology and Neuro-Oncology
    Mario Ganau, MD, PhD, Nikolaos Syrmos, MD, MSc, Marco Paris, MD, and Lara Prisco, MD, MSc

    Nanomedicine and Personalized Care: Facts and Fiction
    David M. Berube, PhD and Emily Winderman, PhD

    Precision Immuno-Oncology: Prospects of Individualized Immunotherapy for Pancreatic Cancer
    Jiajia Zhang, MD, MPH, Christopher L. Wolfgang, MD, MS, PhD, and Lei Zheng, MD, PhD

    Developing a Case-Based Blended Learning Ecosystem to Optimize Precision Medicine: Reducing Overdiagnosis and Overtreatment
    Vivek Podder, MBBS, Binod Dhakal, MD, Gousia Ummae Salma Shaik, MD, Kaushik Sundar, DM, Madhava Sai Sivapuram, MBBS, Vijay Kumar Chattu, MD, and Rakesh Biswas, MD

    Views from the FDA: Precision Medicine, Genetic Variant Databases and Companion Diagnostics
    U.S. Food and Drug Administration

    Protein-Based Nanoparticle Materials for Medical Applications
    Kelsey DeFrates, BSc, Theodore Markiewicz, BSc, Pamela Gallo, BSc, Aaron Rack, BSc, Aubrie Weyhmiller, BSc, Brandon Jarmusik, BSc, and Xiao Hu, PhD

    Nanomedicine and Phage Capsids

    Philip Serwer, PhD, and Elena T. Wright

    Pharmacogenomics: Ethical, Social, and Public Policy Issues
    Yann Joly, PhD, and Denise Avard, PhD

    From Single Level Analysis to Multi-Omics Integrative Approaches: A Powerful Strategy towards the Precision Oncology
    Maria Eugenia Gallo Cantafio, PhD, Katia Grillone, PhD, Daniele Caracciolo, MD, Francesca Scionti, PhD, Mariamena Arbitrio, MD, Vito Barbieri, MD, Licia Pensabene, MD, Pietro Hiram Guzzi, PhD, and Maria Teresa Di Martino, PhD

    Harmonizing Outcomes for Genomic Medicine: Comparison of eMERGE Outcomes to ClinGen Outcome/Intervention Pairs
    Janet L. Williams, MS, Wendy K. Chung, MD, PhD, Alex Fedotov, PhD, Krzysztof Kiryluk, MD, Chunhua Weng, PhD, John J. Connolly, PhD, Margaret Harr, MS, Hakon Hakonarson, MD, PhD, Kathleen A. Leppig, MD, Eric B. Larson, MD, Gail P. Jarvik, MD, PhD, David L. Veenstra, Pharm D, PhD, Christin Hoell, MS, Maureen E. Smith, MS, Ingrid A. Holm, MD, MPH, Josh F. Peterson, MD, MPH, and Marc S. Williams, MD

    Estrogen and Androgen Blockade for Advanced Prostate Cancer in the Era of Precision Medicine
    Tetsuya Fujimura, MD, PhD, Kenichi Takayama, MD, PhD, Satoru Takahashi, MD, PhD, and Satoshi Inoue, MD, PhD

    Precision or Personalized Medicine for Cancer Chemotherapy: Is There a Role for Herbal Medicine?
    Zhijun Wang, PhD, Xuefeng Liu, MD, Rebecca Lucinda Ka Yan Ho, MSc, Christopher Wai Kei Lam, PhD, and Moses Sing Sum Chow, PharmD

    Personomics: The Missing Link in the Evolution from Precision Medicine to Personalized Medicine
    Roy C. Ziegelstein, MD

    Stem Cell Banking for Regenerative and Personalized Medicine
    David T. Harris, PhD

    Overview of Ethical Issues in Nanomedicine
    Raj Bawa, MS, PhD, and Summer Johnson, PhD

    Amphiphilic Nanocarrier Systems for Curcumin Delivery in Neurodegenerative Disorders
    Miora Rakotoarisoa, MS, and Angelina Angelova, PhD

    Peptide-Based Drug Delivery Systems: Future Challenges, Perspectives, and Opportunities in Nanomedicine
    Diego Tesauro, PhD, Antonella Accardo, PhD, Carlo Diaferia, PhD, Vittoria Milano, PhD, Jean Guillon, PhD, Luisa Ronga, PhD, and Filomena Rossi, PhD

    Hydrogels and Their Applications in Targeted Drug Delivery
    Radhika Narayanaswamy, MSc, and Vladimir P. Torchilin, PhD, DSc

    Emergence of Real World Evidence in Precision Medicine
    Neil A. Belson, MS, JD


    Shaker A. Mousa, PhD is an endowed chair, tenured professor of Pharmacology at Albany College of Pharmacy; Vice Provost of Research, executive vice president, and chair of Pharmaceutical Research Institute at Albany, NY.

    Raj Bawa, MS, PhD, is president of Bawa Biotech LLC, a biotech/pharma consultancy and patent law firm based in Ashburn, VA, USA that he founded in 2002.

    Gerald F. Audette, PhD, is an Associate Professor in the Department of Chemistry and member of the Centre for Research on Biomolecular Interactions at York University in Toronto, Canada.

    The carefully-selected range of topics in this masterpiece will be equally beneficial to academia, physicians, drug industry, business, healthcare systems, policymakers, geneticists, regulatory bodies and governments. In the coming decade efforts in nanomedicine and precision medicine will be translated from the bench to the bedside, paving the way for more accurate diagnosis and more precise therapeutics. This review volume is a standard reference resource for anyone involved in the coming healthcare revolution.

    Tatiana K. Bronich, University of Nebraska Medical Center, USA

    The first 3 volumes in this series have been inspirational and form the most definitive and useful references for anyone wishing to know about the technical, clinical, legal, business and regulatory aspects of nanomedicine. The topic has in the past raised expectations to levels that were probably too high, but anyone reading these books will understand the opportunities and barriers much better. This fourth volume was awaited with great interest.

    Peter J. Dobson, University of Oxford, UK

    It is wonderful to see that Nobel Laureate Paul Ehrlich’s vision of "magic bullets" postulated in 1908 may eventually be fully realized along the road from nanomedicine to precision medicine. The power unleashed by elucidation of the genome coupled with the elegance of site-specific drug delivery will revolutionize healthcare in the next century. In my 70-years as a researcher and university professor, nothing has held a greater potential to diagnose and treat diseases in a more customizable, targeted manner. This masterful volume reflects the innovative developments, potential applications and possible bottle-necks in these two interrelated fields.

    S. R. Bawa, Panjab University, India

    Precision medicine and targeted nanomedicines are the "Holy Grail" of medicine and drug delivery; this comprehensive volume highlights their salient features and interconnectivity. A team of distinguished editors and authors have done a superb job focussing on the critical and current issues, masterfully dissecting hype from reality.

    János Szebeni, Semmelweis University School of Medicine, Budapest, Hungary

    The growth, opportunity and promise of nanomedicine has become breathtaking which is why "The Road from Nanomedicine to Precision Medicine" by Mousa, Bawa and Audette is my "go to" reference. It puts cutting-edge nano-developments in context of personalized/precision medicine and the lessons learned from applications in one clinical challenge may serve as a template for other challenges. Use this volume as a reference but be sure to read it for inspiration.

    Nicholas Borys, Celsion Corporation, New Jersey, USA

    As nanomedicine begins to mature further and evolves towards enabling precision medicine, this volume with its punctiliously selected content is destined to become a must-have reference resource. The editors have made an astounding effort that connects different manifestations of nanomedicines with the many modes of developing precision medicine, while illuminating the regulatory pathway and challenges therein for all of us to learn from. Its unique contents will be especially useful to oncology, infectious diseases, degenerative diseases and regenerative medicine.

    Anil R. Diwan, PhD, NanoViricides, Inc., Connecticut, USA

    The untapped solutions from nanotechnology will enable breakthroughs in customized healthcare. This comprehensive edition provides the groundwork of where nanomedicine will lead to tailoring precision medicine for individual patient care.

    Neil Gordon, Guanine Inc., New York, USA