The Road from Nanomedicine to Precision Medicine  book cover
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The Road from Nanomedicine to Precision Medicine




ISBN 9789814800594
Published February 12, 2020 by Jenny Stanford Publishing
1208 Pages

 
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Book Description

The enormous advances in nanomedicine and precision medicine in the past two decades necessitated this comprehensive reference, which can be relied upon by researchers, clinicians, pharmaceutical scientists, regulators, policymakers, and lawyers alike. This standalone, full-color resource broadly surveys innovative technologies and advances pertaining to nanomedicine and precision medicine. In addition, it addresses often-neglected yet crucial areas such as translational medicine, intellectual property law, ethics, policy, FDA regulatory issues, nano-nomenclature, and artificial nano-machines—all accomplished in a user-friendly, broad yet interconnected format. The book is essential reading for the novice and the expert alike in diverse fields such as medicine, law, pharmacy, genomics, biomedical sciences, ethics, and regulatory science. The book’s multidisciplinary approach will attract a global audience and serve as a valuable reference resource for industry, academia, and government.

Table of Contents

PART A

Drug Delivery at the Nanoscale: A Guide for Scientists, Physicians and Lawyers
Raj Bawa, MS, PhD

What Is Precision Medicine? A Primer on Contemporary Issues and Concerns
Kadija Ferryman, PhD, and Mikaela Pitcan, PhD

FDA’s Role in Paving the Way for Personalized Medicine
U.S. Food and Drug Administration

Multifunctional Gold Nanoparticles in Drug Delivery Systems
Zachary I. Stryker, Mehdi Rajabi, PhD, and Shaker A. Mousa, PhD

Nanoparticles and Nanoparticulate Drug Delivery Systems: Impact of Size and Structure on Functionality
Ajit S. Narang, PhD, Rong-Kun Chang, PhD, and Munir A. Hussain, PhD

Self-Assembling Peptide Amphiphiles as a Versatile Future Nanomedicine Platform
Run Chang, MS, and Thomas J. Webster, PhD

Pharmaceutical Applications of Water-Soluble Polymers in Nanomedicine and Drug Delivery
Schuyler A Pruyn, BSc, Mehdi Rajabi, PhD, Mary Adeyeye, BSc, and Shaker A. Mousa, PhD

Nanomaterials: Tools, Technology, and Methodology of Nanotechnology-Based Biomedical Systems for Diagnostics and Therapy
Christian Schmidt, PhD, and Joachim Storsberg, PhD

Nanomagnetic Resonance Imaging (Nano-MRI) Gives Personalized Medicine a New Perspective
Lorenzo Rosa, PhD, Jonathan Blackledge, and Albert Boretti, PhD

Advancing Precision Medicine: Tailoring Personalized Therapies
Kyle B. Matchett, PhD, Niamh Lynam-Lennon, PhD, R. William Watson, PhD, and James A. L. Brown, PhD

Precision Medicine for Alzheimer’s Disease Prevention
Cara L. Berkowitz, BA, Lisa Mosconi, PhD, Olivia Scheyer, BA, Aneela Rahman, BA, Hollie Hristov, FNP, and Richard S. Isaacson, MD

Advanced Porphyrin Nanomaterials for Biological Applications
Haoyuan Huang, PhD, and Jonathan F. Lovell, PhD

Cerium Oxide Nanoparticles as a Novel Reactive Oxygen Modulating Nanodrug
Ece Alpaslan, PhD, and Thomas J. Webster, PhD

Artificial Nanomachines and Nanorobotics
Alexandre Loukanov, PhD, DSc, Hristo Gagov, PhD, and Seiichiro Nakabayashi, PhD

Nanomotors for Nucleic Acid, Protein, Pollutant, and Cell Detection
Alejandro Baeza, PhD, and María Vallet-Regí, PhD

Magneto-Responsive Scaffolds for Tissue Engineering Applications
Adedokun A. Adedoyin, PhD, and Adam K. Ekenseair, PhD

Anti-Cancer and Anti-Angiogenic Properties of Nano-Diamino-Tetrac, A Thyroid Hormone Derivative
Paul J. Davis, MD, and Shaker A. Mousa, MBA, PhD

PART B

Proteomic Profiling and Predictive Biomarkers in Neuro-Traumatology and Neuro-Oncology
Mario Ganau, MD, PhD, Nikolaos Syrmos, MD, MSc, Marco Paris, MD, and Lara Prisco, MD, MSc

Nanomedicine and Personalized Care: Facts and Fiction
David M. Berube, PhD and Emily Winderman, PhD

Precision Immuno-Oncology: Prospects of Individualized Immunotherapy for Pancreatic Cancer
Jiajia Zhang, MD, MPH, Christopher L. Wolfgang, MD, MS, PhD, and Lei Zheng, MD, PhD

Developing a Case-Based Blended Learning Ecosystem to Optimize Precision Medicine: Reducing Overdiagnosis and Overtreatment
Vivek Podder, MBBS, Binod Dhakal, MD, Gousia Ummae Salma Shaik, MD, Kaushik Sundar, DM, Madhava Sai Sivapuram, MBBS, Vijay Kumar Chattu, MD, and Rakesh Biswas, MD

Views from the FDA: Precision Medicine, Genetic Variant Databases and Companion Diagnostics
U.S. Food and Drug Administration

Protein-Based Nanoparticle Materials for Medical Applications
Kelsey DeFrates, BSc, Theodore Markiewicz, BSc, Pamela Gallo, BSc, Aaron Rack, BSc, Aubrie Weyhmiller, BSc, Brandon Jarmusik, BSc, and Xiao Hu, PhD

Nanomedicine and Phage Capsids

Philip Serwer, PhD, and Elena T. Wright

Pharmacogenomics: Ethical, Social, and Public Policy Issues
Yann Joly, PhD, and Denise Avard, PhD

From Single Level Analysis to Multi-Omics Integrative Approaches: A Powerful Strategy towards the Precision Oncology
Maria Eugenia Gallo Cantafio, PhD, Katia Grillone, PhD, Daniele Caracciolo, MD, Francesca Scionti, PhD, Mariamena Arbitrio, MD, Vito Barbieri, MD, Licia Pensabene, MD, Pietro Hiram Guzzi, PhD, and Maria Teresa Di Martino, PhD

Harmonizing Outcomes for Genomic Medicine: Comparison of eMERGE Outcomes to ClinGen Outcome/Intervention Pairs
Janet L. Williams, MS, Wendy K. Chung, MD, PhD, Alex Fedotov, PhD, Krzysztof Kiryluk, MD, Chunhua Weng, PhD, John J. Connolly, PhD, Margaret Harr, MS, Hakon Hakonarson, MD, PhD, Kathleen A. Leppig, MD, Eric B. Larson, MD, Gail P. Jarvik, MD, PhD, David L. Veenstra, Pharm D, PhD, Christin Hoell, MS, Maureen E. Smith, MS, Ingrid A. Holm, MD, MPH, Josh F. Peterson, MD, MPH, and Marc S. Williams, MD

Estrogen and Androgen Blockade for Advanced Prostate Cancer in the Era of Precision Medicine
Tetsuya Fujimura, MD, PhD, Kenichi Takayama, MD, PhD, Satoru Takahashi, MD, PhD, and Satoshi Inoue, MD, PhD

Precision or Personalized Medicine for Cancer Chemotherapy: Is There a Role for Herbal Medicine?
Zhijun Wang, PhD, Xuefeng Liu, MD, Rebecca Lucinda Ka Yan Ho, MSc, Christopher Wai Kei Lam, PhD, and Moses Sing Sum Chow, PharmD

Personomics: The Missing Link in the Evolution from Precision Medicine to Personalized Medicine
Roy C. Ziegelstein, MD

Stem Cell Banking for Regenerative and Personalized Medicine
David T. Harris, PhD

Overview of Ethical Issues in Nanomedicine
Raj Bawa, MS, PhD, and Summer Johnson, PhD

Amphiphilic Nanocarrier Systems for Curcumin Delivery in Neurodegenerative Disorders
Miora Rakotoarisoa, MS, and Angelina Angelova, PhD

Peptide-Based Drug Delivery Systems: Future Challenges, Perspectives, and Opportunities in Nanomedicine
Diego Tesauro, PhD, Antonella Accardo, PhD, Carlo Diaferia, PhD, Vittoria Milano, PhD, Jean Guillon, PhD, Luisa Ronga, PhD, and Filomena Rossi, PhD

Hydrogels and Their Applications in Targeted Drug Delivery
Radhika Narayanaswamy, MSc, and Vladimir P. Torchilin, PhD, DSc

Emergence of Real World Evidence in Precision Medicine
Neil A. Belson, MS, JD

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Editor(s)

Biography

Shaker A. Mousa, PhD is an endowed chair, tenured professor of Pharmacology at Albany College of Pharmacy; Vice Provost of Research, executive vice president, and chair of Pharmaceutical Research Institute at Albany, NY.

Raj Bawa, MS, PhD, is president of Bawa Biotech LLC, a biotech/pharma consultancy and patent law firm based in Ashburn, VA, USA that he founded in 2002.

Gerald F. Audette, PhD, is an Associate Professor in the Department of Chemistry and member of the Centre for Research on Biomolecular Interactions at York University in Toronto, Canada.

Reviews

The carefully-selected range of topics in this masterpiece will be equally beneficial to academia, physicians, drug industry, business, healthcare systems, policymakers, geneticists, regulatory bodies and governments. In the coming decade efforts in nanomedicine and precision medicine will be translated from the bench to the bedside, paving the way for more accurate diagnosis and more precise therapeutics. This review volume is a standard reference resource for anyone involved in the coming healthcare revolution.

Tatiana K. Bronich, University of Nebraska Medical Center, USA

The first 3 volumes in this series have been inspirational and form the most definitive and useful references for anyone wishing to know about the technical, clinical, legal, business and regulatory aspects of nanomedicine. The topic has in the past raised expectations to levels that were probably too high, but anyone reading these books will understand the opportunities and barriers much better. This fourth volume was awaited with great interest.

Peter J. Dobson, University of Oxford, UK

It is wonderful to see that Nobel Laureate Paul Ehrlich’s vision of "magic bullets" postulated in 1908 may eventually be fully realized along the road from nanomedicine to precision medicine. The power unleashed by elucidation of the genome coupled with the elegance of site-specific drug delivery will revolutionize healthcare in the next century. In my 70-years as a researcher and university professor, nothing has held a greater potential to diagnose and treat diseases in a more customizable, targeted manner. This masterful volume reflects the innovative developments, potential applications and possible bottle-necks in these two interrelated fields.

S. R. Bawa, Panjab University, India

Precision medicine and targeted nanomedicines are the "Holy Grail" of medicine and drug delivery; this comprehensive volume highlights their salient features and interconnectivity. A team of distinguished editors and authors have done a superb job focussing on the critical and current issues, masterfully dissecting hype from reality.

János Szebeni, Semmelweis University School of Medicine, Budapest, Hungary

The growth, opportunity and promise of nanomedicine has become breathtaking which is why "The Road from Nanomedicine to Precision Medicine" by Mousa, Bawa and Audette is my "go to" reference. It puts cutting-edge nano-developments in context of personalized/precision medicine and the lessons learned from applications in one clinical challenge may serve as a template for other challenges. Use this volume as a reference but be sure to read it for inspiration.

Nicholas Borys, Celsion Corporation, New Jersey, USA

As nanomedicine begins to mature further and evolves towards enabling precision medicine, this volume with its punctiliously selected content is destined to become a must-have reference resource. The editors have made an astounding effort that connects different manifestations of nanomedicines with the many modes of developing precision medicine, while illuminating the regulatory pathway and challenges therein for all of us to learn from. Its unique contents will be especially useful to oncology, infectious diseases, degenerative diseases and regenerative medicine.

Anil R. Diwan, PhD, NanoViricides, Inc., Connecticut, USA

The untapped solutions from nanotechnology will enable breakthroughs in customized healthcare. This comprehensive edition provides the groundwork of where nanomedicine will lead to tailoring precision medicine for individual patient care.

Neil Gordon, Guanine Inc., New York, USA