The Role of Glia in Neurotoxicity: 2nd Edition (Hardback) book cover

The Role of Glia in Neurotoxicity

2nd Edition

Edited by Michael Aschner, Lucio G. Costa

CRC Press

480 pages | 77 B/W Illus.

Purchasing Options:$ = USD
Hardback: 9780849317941
pub: 2004-12-28
eBook (VitalSource) : 9780429128608
pub: 2004-12-28
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Presenting the latest research in glial cell function gleaned from new techniques in imaging and molecular biology, The Role of Glia in Neurotoxicity, Second Edition covers multiple aspects of glial cells, including morphology, physiology, pharmacology, biochemistry, pathology, and their involvement in the pathophysiology of neurological diseases. The book is structured to examine the interactions between glial cells and neurons during development, adulthood, and senescence, followed by specific examples of directly mediated glial neurotoxicity. The book also covers miscellaneous topics in glial physiology/biochemistry such as signaling and edema. The book includes coverage of advances in our knowledge and understanding of glial physiology and biochemistry.

Discover what's new in the Second Edition:

Neuronal-glia metabolic interactions

Neuronal-glia interactions (glutamate homeostasis)

Zinc transporters in glia

Energy deprivation/mitochondrial dysfunction - unique astrocyte susceptibilities

Astrocytes and MPTP neurotoxicity

Astroglia and food toxins

Current understanding of the importance of glia has caused a boom in published information. Yet while many of the published textbooks are multifaceted and multidisciplinary, none includes the role of glia in neurotoxicity. Written by leaders in the field of glial research, this text fills this missing gap in the literature. Broader in scope than the first edition, including contributions from internationally known researchers, this is still the only book dedicated to exploring the role of glial cells in mediating neurotoxicology.


  • Summarizes the latest research in glial cell function gleaned from new techniques in imaging and molecular biology

  • Contains tables and figures that give you quick and easy access to precise data

  • Includes a contemporary summary of literature that puts information useful for grant submissions at your fingertips

  • Features new chapters covering metabolic interactions, glutamate homeostasis, transporters, energy deprivation/mitochondrial dysfunction, astrocytes, and food toxins

  • Explores the role of glial cells in mediating neurotoxicity and incorporates information on specific effects of many compounds
  • Reviews

    "The Role of Glia in Neurotoxicity, Second Edition gets a gold star from me. All neuroscientists and any anatomic pathologists that make their living evaluating toxicities of the central and peripheral nervous systems are going to find the book valuable. …this text represents the most concise and readable knowledge base of glial cell research applicable to the pathologist."

    Dr. M. T. Butt, Charles River Laboratories Pathology Association (PAI), Veterinary Pathology, 2006

    Table of Contents

    Neural Precursor Cells and Toxicant Action: Addressing the Analysis of Low-Level Toxicant Exposure, M. Noble

    The Role of Microglia in Neurotoxicity, W.J. Streit

    Schwann Cell Neurotoxicity, A.D. Toews, G.J. Harry, and P. Morell

    Function of Astrocyte Cytochrome P450 in Control of Xenobiotic Metabolism, R.P. Meyer, B. Volk, and R. Knoth

    The Reactive Astrocyte, M.D. Norenberg

    Molecular Mechanisms of Glutamate and Glutamine Transport in Astrocytes, S. Bröer

    Neuronal-Astrocytic interactions (TCA cycling), U. Sonnewald, A. Schousboe, and H.S. Waagepetersen

    Cytokines in Neuronal-Glial Interaction, B. Viviani and M. Marinovich

    Signaling Mechanisms Underlying Toxicant-Induced Gliosis, K. Sriram and J.P. O'Callaghan

    Astrocyte Cellular Swelling: Mechanisms and Relevance to Brain Edema, H. Pasantes-Morales and R. Franco

    Astrocyte Metallothioneins and Physiological and Pathological Consequences to Brain Injury, J. Hidalgo

    Peripheral Benzodiazepine Receptor Imaging in Glial Cells: Molecular Sensors of Brain Pathology, T.R. Guilarte

    Astrocyte-Neuronal Interaction and Oxidative Injury: Rose of Glia in Neurotoxicity, V. Chock and R. Giffard

    Astrocytes in Acute Energy Deprivation Syndromes, E.S. Williams, A.D. Phelka, D.E. Ray, and M.A. Philbert

    The Role of Multiple Drug Resistance in Neuroglial Survival: Lessons from Human Epileptic Brain, K.M. Kight, K.L. Hallene, G. Dini, and D. Janigro

    Pathogenesis of HIV Associated Dementia and Multiple Sclerosis: Role of Microglia and Astrocytes, A. Minagar, P. Shapshak, and J.S. Alexander

    Possible Detrimental Role of Astrocytic Activation During the Subacute Phase of Permanent Regional Cerebral Ischemia in the Rat, T. Asano, N. Tateishi, and T. Mori

    Role of Microglia and Astrocytes in Alzheimer´s Disease, P. Schubert and S. Ferroni

    Developmental Efficts of Xenobiotics on Thyroid Hormone Regulation in the CNS with Emphasis on Glial Function, O.P. Soldin

    Astrocytes in Ammonia Neurotoxicity: A Target, A Mediator, and a Shield, J. Albrecht

    Alcohol and Glia in the Developing Brain, L.G. Costa, K. Yagle, A. Vitalone, and M. Guizzetti

    Zinc Homeostatic Proteins and Glia, W.F. Silverman

    Iron and Glial Toxicity, J.R. Connor, X. Zhang, and P. Cheepsunthorn

    Astroglia and Methylmercury Neurotoxicity, G. Shanker, T. Syversen, J.L. Aschner, and Michael Aschner

    Manganese, V.A. Fitsanakis, S.J. Garcia, and M. Aschner

    Astroglia and Lead Neurotoxicity, E. Tiffany-Castiglioni and Y. Qian

    Role of Glia in MPTP Toxicity and Parkinson's Disease, L.G. Costa and M. Aschner

    Subject Categories

    BISAC Subject Codes/Headings:
    MEDICAL / Pharmacology
    MEDICAL / Toxicology
    SCIENCE / Life Sciences / Neuroscience