1st Edition

The Routledge Handbook on Biochemistry of Exercise

    584 Pages 94 B/W Illustrations
    by Routledge

    584 Pages 94 B/W Illustrations
    by Routledge

    From its early beginnings in the 1960s, the academic field of biochemistry of exercise has expanded beyond examining and describing metabolic responses to exercise and adaptations to training to include a wide understanding of molecular biology, cell signalling, interorgan communication, stem cell physiology, and a host of other cellular and biochemical mechanisms regulating acute responses and chronic adaptations related to exercise performance, human health/disease, nutrition, and cellular functioning.

    The Routledge Handbook on Biochemistry of Exercise is the first book to pull together the full depth and breadth of this subject and to update a rapidly expanding field of study with current issues and controversies and a look forward to future research directions. Bringing together many experts and leading scientists, the book emphasizes the current understanding of the underlying metabolic, cellular, genetic, and cell signalling mechanisms associated with physical activity, exercise, training, and athletic performance as they relate to, interact with, and regulate cellular and muscular adaptations and consequent effects on human health/disease, nutrition and weight control, and human performance.

    With more emphasis than ever on the need to be physically active and the role that being active plays in our overall health from a whole-body level down to the cell, this book makes an important contribution for scholars, medical practitioners, nutritionists, and coaches/trainers working in research and with a wide range of clients. This text is important reading for all students, scholars, and others with an interest in health, nutrition, and exercise/training in general.

    Section 1 - Regulation of metabolism and responses to acute exercise


    Rebecca EK MacPherson

    1. Whole Body Regulation of Energy Expenditure, Exercise Fuel Selection, and Dietary Recommendations

    Peter WR Lemon

    2. Energy Provision, Fuel Use and Regulation of Skeletal Muscle Metabolism During the Exercise Intensity/Duration Continuum

    Lawrence L Spriet

    3. Adipose Tissue (adipokinome), Skeletal Muscle (myokinome) and Liver (hepatokinome) as Endocrine Regulators during Exercise

    Logan K. Townsend, Greg L. McKie, Hesham Shamshoum, and David C. Wright

    4. Regulation of Skeletal Muscle Reactive Oxygen Species During Exercise

    Catherine A. Bellissimo and Christopher G.R. Perry

    5. Biochemical contributors to exercise fatigue

    Arthur J Cheng, Maja Schlittler, and Håkan Westerblad

    6. Mechanotransduction Mechanisms of Hypertrophy and Performance with Resistance Exercise

    Andrew C. Fry, Justin X. Nicoll, and Luke A. Olsen

    7. Responses to muscular exercise, Heat Shock Proteins as regulators of inflammation and mitochondrial quality control

    Alex T. Von Schulze and Paige C. Geiger

    8. Signaling pathways in regulation of cellular responses to exercise

    Anders Gudiksen, Stine Ringholm and Henriette Pilegaard

    Section II: Exercise Biochemistry, Chronic Training, and Athletic Performance


    Paul J LeBlanc

    9. Exercise-Induced Mitochondrial Biogenesis: Molecular Regulation, Impact of Training, and Influence on Exercise Performance

    Hashim Islam, Jacob T. Bonafiglia, Cesare Granata, and Brendon J. Gurd

    10: Resistance Exercise Training and the Regulation of Muscle Protein Synthesis

    Nathan Hodson, Daniel R. Moore, and Chris McGlory

    11: Cellular Adaptations to High-Intensity and Sprint Interval Training

    Martin J. MacInnis and Lauren E. Skelly

    12: Regulation of Muscle Satellite Cell Activation and Cycles Consequent to Various Forms of Training

    Sophie Joanisse and Gianni Parise

    13: Biochemical and Metabolic Limitations to Athletic Performance

    Brendan M. Gabriel

    14: Genetic Limitations to Athletic Performance

    Colin N Moran and Guan Wang

    15: The Role of Epigenetics in Skeletal Muscle Adaptations to Exercise and Exercise Training

    Sean L. McGee

    16: Statistical Considerations and Biological Mechanisms Underlying Individual Differences in Adaptations to Exercise Training

    Jacob T. Bonafiglia, Hashim Islam, Nir Eynon, and Brendon J. Gurd

    17: Effects of Hypoxia/Blood Flow Restriction on Cellular Adaptations to Training

    Scott J. Dankel and Jeremy P. Loenneke


    Section III: Exercise Biochemistry/Nutrition Nexus in Sport and Physical Activity


    Andrea R Josse

    18: Exercise and Dietary Influences on the Regulation of Energy Balance and Implications for Body Weight Control

    Andrea M. Brennan and Robert Ross

    19: Dietary Manipulation for Optimizing Endurance Training Adaptations and Performance: Carbohydrate vs. Fat

    Jamie Whitfield and Louise M. Burke

    20: Dietary Influence on Muscle Protein Synthesis and Hypertrophy

    James McKendry and Stuart M. Phillips

    21: Micronutrients and Nutraceuticals: Effects on Exercise Performance

    Stella L. Volpe and Quentin Nichols

    22: Biochemistry of Buffering Capacity and Ingestion of Buffers in Exercise and Athletic Performance

    Bryan Saunders, Guilherme G. Artioli, Eimear Dolan, Rebecca L. Jones, Joseph Matthews, and Craig Sale

    23: Creatine augmentation for muscle and bone responses to exercise

    Philip D. Chilibeck

    24: Biochemistry of Caffeine's Influence on Exercise Performance

    Jane Shearer, Robyn F. Madden , and Jill A. Parnell

    25: Nutrigenomics for Sport and Exercise Performance

    Nanci S. Guest, Marc Sicova , and Ahmed El-Sohemy

    Section IV: Exercise Biochemistry Relative to Health Through the Lifespan


    Peter M Tiidus

    26: Mitochondrial Dysfunction in Chronic Disease

    Christopher Newell, Heather Leduc-Pessah, Aneal Khan and Jane Shearer

    27: Exercise training, mitochondrial adaptations and aging

    Nashwa Cheema, Matthew Triolo and David.A. Hood,

    28: Biochemistry of Exercise Effects in Type II Diabetes

    Barry Braun, Karyn L. Hamilton, Dan S. Lark and Alissa Newman

    29: Biochemistry of Exercise Training and Mitigation of Cardiovascular Disease

    Barry A. Franklin and John C. Quindry

    30: Biochemistry of Exercise Training and Type 1 Diabetes

    Sam N. Scott, Matt Cocks, Anton J. M. Wagenmakers, Sam O. Shepherd and Michael C. Riddell

    31: Biochemistry of Exercise Training: Mitigation of Cancers

    Brittany R. Counts, Jessica L. Halle and James A. Carson

    32: Biochemistry of Exercise Training; Effects on Bone

    Panagiota Klentrou and Rozalia Kouvelioti

    33: Metabolic Effects of Exercise on Childhood Obesity

    Kristi B. Adamo, Taniya S. Nagpal and Danilo F. DaSilva


    Peter Tiidus is Dean of the Faculty of Applied Health Sciences and a Professor at Brock University, Canada.

    Rebecca E. K. MacPherson is an Assistant Professor at Brock University, Canada.

    Paul J. LeBlanc is a Professor in Health Sciences at Brock University, Canada.

    Andrea R. Josse is an Assistant Professor at York University, Canada.