The identification of the role of tumor stroma—the tissue in the surroundings of cancer cells—in cancer development, progression, and metastasis has revolutionized the fields of cancer biology as well as cancer therapeutics. This book provides a comprehensive overview of this rapidly-evolving field including tumor stroma biology, therapeutic targets, molecular imaging, and advanced tumor stroma in vitro models. The book will serve as a handbook for graduate students, postgraduate researchers, pharmaceutical scientists, and biomedical engineers.
1. The Tumor Stroma: Key Component of Solid Tumors
Jai Prakash
2. Cancer-Associated Fibroblasts: Building Blocks of the Tumor Stroma
Ahmed M. R. H. Mostafa, Alaa M. Ramadan, Arne Östman, and Jai Prakash
3. Tumor-Associated Macrophages: Biological Understanding and Therapeutic Opportunities
Siavash Mansouri and Rajkumar Savai
4. Biomarkers in the Tumor Stroma and Their Clinical Relevance
Barnali Deb, Rajan Datar, Sewanti Limaye, and Prashant Kumar
5. Physical Properties of the Tumor Stroma and Therapeutic Strategies
Zalak Bhut, Marcel Alexander Heinrich, and Jai Prakash
6. TGF-β Signalling in Cancer: Role and Therapeutic Targeting of the Tumour Stroma
Adilson Fonseca Teixeira, Peter ten Dijke, and Hong-Jian Zhu
7. Role of Integrins in the Tumor Stroma
Kunal Pednekar, Marcel Alexander Heinrich, and Jai Prakash
8. MicroRNA in the Tumor Stroma: Diagnostic and Therapeutic Implications
Tao Lu, Leon W. M. M. Terstappen, and Jai Prakash
9. Molecular Imaging of the Tumor Stroma and Beyond
F. A. Vuijk, R. Houvast, V. M. Baart, C. J. H. van de Velde, A. L. Vahrmeijer, D. E. Hilling, J. S. D. Mieog, M. Slingerland, L. F. de Geus-Oei, L. J. A. C. Hawinkels, and C. F. M Sier
10. 3D in vitro Models to Mimic the Tumor Microenvironment
Marcel Alexander Heinrich, Ngoc Tien Huynh, Yu Shrike Zhang, and Jai Prakash
Biography
Jai Prakash, Professor at the University of Twente in the Netherlands, is a pharmaceutical and bioentrepreneurial scientist working in the field of engineered therapeutics against cancer and fibrosis. He is educated as a pharmacologist and obtained his PhD (with honors) from the University of Groningen, the Netherlands. Earlier, he worked as vice president at BiOrion Technologies and Assistant Professor at Karolinska Institutet, Sweden, and then joined as a tenure track professor at the University of Twente. He is also a founder and CSO of ScarTec Therapeutics and the president of BeNeLux and France local chapter for the Controlled Release Society (CRS). His research interests are in designing therapeutic technologies to disrupt the crosstalk between tumor cells and stromal cells and in developing advanced 3D in vitro models to mimic the tumor microenvironment.
