Therapeutics, Evidence and Decision-Making: 1st Edition (Paperback) book cover

Therapeutics, Evidence and Decision-Making

1st Edition

By Michael D Rawlins

CRC Press

256 pages

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Paperback: 9781853159473
pub: 2011-07-29
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This book is intended to help decision-makers use, assess and appraise the evidence that underpins decisions about the use of therapeutic interventions. It will inform decision-makers about the nature of evidence, the strengths and weaknesses of the available approaches, and how these can be most effectively distilled for the purpose of reaching reliable conclusions. It aims to encourage decision-makers to base their judgements about the use of therapeutic interventions on an informed appraisal of the totality of the evidence base. Is it reliable? Is it generalisable beyond the context of the environment in which the primary research has been conducted? Do the intervention's benefits outweigh its harms? Is it cost effective as well as clinically effective? Is it, indeed, fit-for-purpose? Ultimately, good judgement is at the heart of decision-making in therapeutics.

An invaluable text for all physicians, pharmacists, nurses, health commissioners and purchasers and indeed anyone having to make decisions concerning evidence-based therapeutics.

Table of Contents


The nature of evidence


Clinical endpoints of benefits and harms

Statistical expressions of benefit and harm

Bias and confounding

Systematic reviews

Randomized controlled trials

General principles

Stopping rules

Analysis of subgroups



Observational studies

General overview

Historical controlled trials

Concurrent cohort studies

Case-control designs


Case reports

Qualitative research

Approaches and methods

Uses in the evaluation of therapeutic interventions

Economic evaluation

General principles

Cost-effectiveness, cost-utility and cost-minimization analyses

Cost-consequences analysis


For individuals

For populations

About the Author

"Professor Sir Michael Rawlins MD FRCP(Lond) FRCP(Edin) FFPM FMedSci, National Institute for Clinical Excellence, London, UK


Subject Categories

BISAC Subject Codes/Headings:
BUSINESS & ECONOMICS / Industries / Service Industries
LAW / Medical Law & Legislation
MEDICAL / General
MEDICAL / Administration
MEDICAL / Pharmacy