Thermal Analysis of Pharmaceuticals: 1st Edition (Hardback) book cover

Thermal Analysis of Pharmaceuticals

1st Edition

Edited by Duncan Q.M. Craig, Mike Reading

CRC Press

414 pages | 95 B/W Illus.

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pub: 2006-12-21
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Description

As a result of the Process Analytical Technologies (PAT) initiative launched by the U.S. Food and Drug Administration (FDA), analytical development is receiving more attention within the pharmaceutical industry. Illustrating the importance of analytical methodologies, Thermal Analysis of Pharmaceuticals presents reliable and versatile characterization tools for the successful development of pharmaceutical products. It draws attention to the most widely applicable methods and demonstrates how to interpret the associated data.

The book opens with the first three chapters devoted to differential scanning calorimetry (DSC), the most commonly used thermal method. These chapters cover the principles, optimal use, and pharmaceutical applications of the method. Subsequent chapters explore modulated temperature DSC, thermogravimetric analysis, thermal microscopy, microcalorimetry, high sensitivity DSC, dynamic mechanical analysis, and thermally stimulated current, all of which have attracted great interest within the pharmaceutical field. The chapters include theoretical background, measurement optimization, and pharmaceutical applications of each technique.

Exploring important techniques for characterizing the physical structure and properties of pharmaceutical materials, Thermal Analysis of Pharmaceuticals achieves an ideal balance in the depth, relevance, and accessibility of topics presented. The book provides an excellent overview of this key area in pharmaceutical development.

Reviews

“… presents reliable and versatile characterization tools for the successful development of pharmaceutical products. It draws attention to the most widely applicable methods and demonstrates how to interpret the associated data. … achieves and ideal balance in the depth, relevance, and accessibility of topic presented. The book provides an excellent overview of this key area in pharmaceutical development.”

— In Anticancer Research, Vol. 27, No. 3B, May/June 2007

"The editors did a really good job in creating a fine balance between topics of commonly used, well-established methods, and of techniques that are the focus of recent research efforts . . . Due to the high scientific value, timely industrial relevance, and didactic approach, this book is an invaluable information resource for readers both in academia and industry, be they beginners or experts. I warmly recommend this book to everybody involved in solid-state analysis of pharmaceuticals, because it is the must have that I have long been waiting for."

– Dr. Ádám Demeter, Gedeon Richter Plc, in ChemMedChem, 2008, No. 3

Table of Contents

Principles of Differential Scanning Calorimetry

Mike Reading and Duncan Q.M. Craig

Optimizing DSC Experiments

Trevor Lever

Pharmaceutical Applications of DSC

Duncan Q.M. Craig

Modulated Temperature Differential Scanning Calorimetry

Mike Reading, Duncan Q.M. Craig, John R. Murphy, and Vicky L. Kett

Thermogravimetric Analysis: Basic Principles

Andrew K. Galwey and Duncan Q.M. Craig

Thermogravimetric Analysis: Pharmaceutical Applications

Duncan Q.M. Craig and Andrew K. Galwey

Thermal Microscopy

Imre M. Vitez and Ann W. Newman

Principles and Pharmaceutical Applications of Isothermal

Microcalorimetry

Graham Buckton

High-Sensitivity Differential Scanning Calorimetry

Simon Gaisford

Thermorheological (Dynamic Oscillatory) Characterization of

Pharmaceutical and Biomedical Polymers

David S. Jones

The Use of Thermally Stimulated Current Spectroscopy in the

Pharmaceutical Sciences

N. Boutonnet-Fagegaltier, A. Lamure, J. Menegotto, C. Lacabanne, A. Caron, H. Duplaa, and M. Bauer Index

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
SCI013010
SCIENCE / Chemistry / Analytic