1st Edition

Thyroid Cancer From Emergent Biotechnologies to Clinical Practice Guidelines

Edited By Angelo Carpi, Jeffrey I Mechanick Copyright 2011
    416 Pages
    by CRC Press

    408 Pages
    by CRC Press

    The current age of clinical medicine is witnessing biotechnological innovation at an unprecedented pace. As a result, the recently popularized clinical practice guidelines (CPG), as a tool to assist clinical decision-making, have been struggling to keep up. Thyroid Cancer: From Emergent Biotechnology to Clinical Practice Guidelines rides the wave of medical innovation, analyzing current and future CPG, and providing an up-to-date and comprehensive treatise on thyroid cancer, its diagnosis, and treatment.

    A synthesis of ideas by prominent world experts in the field of thyroid cancer research and clinical practice, Thyroid Cancer covers:

    • Technologically-advanced diagnostic procedures and therapeutic interventions

    • Diagnostic techniques employed in the detection and follow-up of thyroid cancer including ultrasound, needle aspiration techniques, CT, PET, PET-CT, and MRI

    • Basic principles of systems biology, molecular and translational medicine, CPG development, and risk stratification for thyroid cancer

    • How CPG contain knowledge gaps and produce uncertainty

    • Advances in the field, including new surgical techniques, molecular targeted therapies, external beam radiation therapy, and chemotherapy

    A comprehensive, scientific description of current and future diagnostic and therapeutic modalities for the management of thyroid cancer, this treatise is an indispensible reference for both the specialist and referring physician.

      Principles of Translational Medicine and Applications to Thyroid Cancer Investigation. Systems Biology - An Overview. Genetic and Epigenetic Alterations in the MAP Kinase and PI3K/Akt Pathways in Thyroid Cancer. Genetic and Molecular Pathophysiology of Medullary Thyroid Carcinoma. Risk Stratification in Differentiated Thyroid Cancer. Clinical Practice Guidelines for Thyroid Cancer: Where Are We Now? Illustrative Case Studies of Thyroid-Carcinoma and the Emerging Role of Molecular Medicine. Advances In Thyroid Ultrasound For Detection And Follow-Up Of Thyroid Malignancies: Technical And Clinical Aspects. Multimodality Imaging and Aspiration Biopsy Guidance in the Perioperative Management of Thyroid Carcinoma. The Use of Diagnostic Radiotracers in Thyroid Cancer. PET-CT Scanning in the Management of Thyroid Cancer: Experience with a Cohort of 100 Patients. The Emerging Role of Percutaneous Needle Biopsy and Molecular Tumor Marker Analysis for the Preoperative Selection of Thyroid Nodules. Image-guided Mini-invasive Ablation of Thyroid Tumors and Distant Metastases. Thyroidectomy and Neck Exploration: New Surgical Approaches. Thyroid Surgery Performed under Local Anesthesia & Same-Day Surgery. The Use of Therapeutic Radiotracers in Thyroid Cancer. Role of Chemotherapy in Thyroid Cancer. Role of NF-KB In thyroid cancer. Biologically Targeted Therapies for Thyroid Cancers. Molecular Targeted Therapies of Medullary Thyroid Carcinoma.


      Angelo Carpi, MD is a clinical researcher at the University Hospital of Pisa. He is also an associate professor of Internal Medicine at Pisa University.

      Jeffrey I. Mechanick, MD, Mount Sinai School of Medicine, New York City, is a Clinical Professor within the Department of Medicine, Division of Endocrinology, Diabetes, and Bone Disease at the Mount Sinai School of Medicine.