Tight Junctions: 2nd Edition (Hardback) book cover

Tight Junctions

2nd Edition

Edited by Marcelino Cereijido, James M. Anderson

CRC Press

792 pages | 350 B/W Illus.

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Hardback: 9780849323836
pub: 2001-06-26
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pub: 2001-06-26
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As the first detailed overview of the subject, Tight Junctions brought together diverse perspectives from leading investigators to provide a multidisciplinary overview of the field. Since its publication in 1992, there has been an explosion of information about tight junctions, particularly in the area of molecular structure, cell and molecular biology, genetics and physiology. The field has advanced so fast and so far that it influences many areas of biology and now has practical implications for pharmacology of drug delivery and understanding a wide range of diseases altering epithelial permeability.

Table of Contents

Introduction: Evolution of Ideas on the Tight Junction

Ultrastructure and Immuno-Labeling of the Tight Junction

Intercellular Junctions of Invertebrates

Tight Junction Permeability to Ions and Water

The Relationship between Structure and Function of Tight Junctions

General Themes in Cell-Cell Junctions and Cell Adhesion

Protein Targeting Pathways and Sorting Signals in Epithelial Cells

Biogenesis of Epithelial Polarity and Tight Junctions

Optical Methods for the Study of Tight Junctions

The Claudin Family and Occludin

The Cytoplasmic Plaque Proteins of the Tight Junction

Organization and Regulation of the Tight Junction by the Actin-Myosin Cytoskeleton

Developmental Assembly of the Tight Junction

Tight Junctions and Cell Surface Lipid Polarity

Physiological Regulation of Tight Junction Permeability by Na+ Nutrient Cotransport

Extacellular Macromolecules Modulate Epethelial Permeability

Intracellular Signaling in Classical and New Tight Junction Functions

Regulation of Tight Junction Permeability in the Mammary Gland

Unique Aspects of the Blood-Brain Barrier

Teleost Chloride Cell Tight Junctions: Environmental salinity and Dynamic Stuctural Changes

Tight Junctions and Proteases

Claudins Mediate Specific Paracellular Fluxes in Vivo

Microbial Pathogens that Affect Tight Junctions

Interactions between Clostridium Perfringens Enterotoxin and Tight Junction Proteins

Ischemia Induced Tight Junction Dysfunction in the Kidney

Tight Junctions in Intestinal Inflammation

Tight Junctions in Liver Disease

The Tight Junctions in the Testis

Relationship between Tight Junctions and Leukocyte Transmigration

Ocular Tight Junctions in Health, Disease, and Glaucoma

Implications of Transport via the Paracellular Pathway on drug Development

Pathological and Therapeutical Implications of Macromolecules Passage through the Tight Junction

Functions of OSP/Claudin11-Containing Parallel Tight Junctions

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Oncology
MEDICAL / Pharmacology
SCIENCE / Life Sciences / Cytology