1st Edition

Tissue Engineering Principles and Practices

    771 Pages 130 B/W Illustrations
    by CRC Press

    771 Pages 130 B/W Illustrations
    by CRC Press

    Tissue engineering research continues to captivate the interest of researchers and the general public alike. Popular media outlets like The New York Times, Time, and Wired continue to engage a wide audience and foster excitement for the field as regenerative medicine inches toward becoming a clinical reality. Putting the numerous advances in the field into a broad context, Tissue Engineering: Principles and Practices explores current thoughts on the development of engineered tissues.

    With contributions from experts and pioneers, this book begins with coverage of the fundamentals, details the supporting technology, and then elucidates their applications in tissue engineering. It explores strategic directions, nanobiomaterials, biomimetics, gene therapy, cell engineering, and more. The chapters then explore the applications of these technologies in areas such as bone engineering, cartilage tissue, dental tissue, vascular engineering, and neural engineering. A comprehensive overview of major research topics in tissue engineering, the book:

    • Examines the properties of stem cells, primary cells, growth factors, and extracellular matrix as well as their impact on the development of tissue-engineered devices
    • Focuses upon those strategies typically incorporated into tissue-engineered devices or utilized in their development, including scaffolds, nanocomposites, bioreactors, drug delivery systems, and gene therapy techniques
    • Presents synthetic tissues and organs that are currently under development for regenerative medicine applications

    The contributing authors are a diverse group with backgrounds in academia, clinical medicine, and industry. Furthermore, this book includes contributions from Europe, Asia, and North America, helping to broaden the views on the development and application of tissue-engineered devices. The book provides a useful reference for courses devoted to tissue engineering fundamentals and those laboratories developing tissue-engineered devices for regenerative medicine therapy.

    Strategic Directions, Peter C. Johnson
    Silks, Monica A. Serban and David L. Kaplan
    Calcium Phosphates, Kemal Sariibrahimoglu, Joop G.C. Wolke, Sander C.G. Leeuwenburgh, and John A. Jansen
    Engineered Protein Biomaterials, Andreina Parisi-Amon and Sarah C. Heilshorn
    Synthetic Biomaterials, Joshua S. Katz and Jason A. Burdick
    Growth Factors and Morphogens: Signals for Tissue Engineering, A. Hari Reddi
    Signal Expression, Martha O. Wang and John P. Fisher
    Pluripotent Stem Cells, Todd C. McDevitt and Mellissa A. Kinney
    Hematopoietic Stem Cells, Ian M. Kaplan, Sebastien Morisot, and Curt I. Civin
    Mesenchymal Stem Cells, Pamela C. Yelick and Weibo Zhang

    Enabling Technologies
    Nanobiomaterials for Tissue Engineering, Pramod K. Avti, Sunny C. Patel, Pushpinder Uppal, Grace O’Malley, Joseph Garlow, and Balaji Sitharaman
    Biomimetic Approaches in Tissue Engineering, Indong Jun, Min Sup Kim, Ji-Hye Lee, Young Min Shin, and Heungsoo Shin
    Molecular Biology Techniques, X.G. Chen, Y.L. Fang, and W.T. Godbey
    Biomaterial Mechanics, Kimberly M. Stroka, Leann L. Norman, and Helim Aranda-Espinoza
    Mechanical Conditioning, Elaine L. Lee and Horst A. von Recum
    Micropatterned Biomaterials for Cell and Tissue Engineering, Murugan Ramalingam and Ali Khademhosseini
    Drug Delivery, Prinda Wanakule and Krishnendu Roy
    Gene Therapy, Abhay Pandit, C. Holladay, M. Kulkarni, and W. Minor
    Nanotechnology-Based Cell Engineering Strategies for Tissue Engineering and Regenerative Medicine Applications, Joaquim Miguel Oliveira, João Filipe Mano, and Rui Luís Reis
    Cell Encapsulation, Stephanie J. Bryant
    Coculture Systems for Mesenchymal Stem Cells, Song P. Seto and Johnna S. Temenoff
    Tissue Engineering Bioreactors, Sarindr Bhumiratana, Elisa Cimetta, Nina Tandon, Warren Grayson, Milica Radisic, and Gordana Vunjak-Novakovic
    Shear Forces, Jose F. Alvarez-Barreto, Samuel B. VanGordon, Brandon W. Engebretson, and Vasillios I. Sikavitsas
    Vascularization of Engineered Tissues, Monica L. Moya and Eric M. Brey
    Biomedical Imaging of Engineered Tissues, Nicholas E. Simpson and Athanassios Sambanis
    Multiscale Modeling of In Vitro Tissue Cultivation, Kyriacos Zygourakis

    Bone Engineering, Lucas A. Kinard, Antonios G. Mikos, and F. Kurtis Kasper
    Dental and Craniofacial Bioengineering, Hemin Nie and Jeremy J. Mao
    Tendon and Ligament Engineering, Nicholas Sears, Tyler Touchet, Hugh Benhardt, and Elizabeth Cosgriff-Hernández
    Cartilage Tissue Engineering, Emily E. Coates and John P. Fisher
    TMJ Engineering, Michael S. Detamore
    Interface Tissue Engineering, Helen H. Lu, Nora Khanarian, Kristen Moffat, and Siddarth Subramony
    The Bioengineering of Dental Tissues, Rena N. D’Souza, Katherine R. Regan, Kerstin M. Galler, and Songtao Shi
    Tissue Engineering of the Urogenital System, In Kap Ko, Anthony Atala, and James J. Yoo
    Vascular Tissue Engineering, Laura J. Suggs
    Neural Engineering, Yen-Chih Lin and Kacey G. Marra
    Tumor Engineering: Applications for Cancer Biology and Drug Development, Joseph A. Ludwig and Emily Burdett


    John P. Fisher, Antonios G. Mikos, Joseph D. Bronzino, Donald R. Peterson