Tissue engineering aims to develop biological substitutes that restore, maintain, or improve damaged tissue and organ functionality. To date, numerous stem cells and biomaterials have been explored for a variety of tissue and organ regeneration. The challenge for existing stem cell–based techniques is that current therapies lack controlled environments that are crucial for regulating stem cell engraftment and differentiation in vivo, because stem cells are rather sensitive to even minute changes in their environment. Micro- and nanotechnology hold great potential to fabricate biomimetic spatiotemporally controlled scaffolds as well as control stem cell behavior and fate by micro- and nanoscale cues.
This book presents the latest micro- and nanotechnologies used to manipulate stem cell behaviors, which is a critical area for regenerative medicine. Moreover, it covers and details cutting-edge research in nano- and microfabrication techniques and biomaterials for the regeneration of various tissues and organs, such as bone, cartilage, craniofacial, osteochondral, muscle, bladder, cardiac, and vascular tissues.
Table of Contents
Nano and Microtechnology
Nano/Microfibrication Techniques for Tissue and Organ Regeneration, Benjamin Holmes, Thomas J. Webster, and Lijie Grace Zhang
Three Dimensional Micropatterning of Biomaterial Scaffolds for Tissue Engineering, Joseph C. Hoffmann and Jennifer L. West
Nanobiotechnology and Biomaterials for Regenerative Medicine, Nupura S. Bhise and Jordan J. Green
Micro- and Nanotechnology Engineering Strategies for Tissue Interface Regeneration and Repair, Torri E.Rinker and Johnna Temenoff
Spatiotemporal Genetic Control of Cellular Systems, Lauren R. Polstein and Charles A. Gersbach
Biomimetic Design of Extracellular Matrix-like Substrate for Tissue Regeneration, Chao Jia, Seyed Babak Mahjour, Lawrence Chan, Da-wei Hou, and Hongjun Wang
Degradable Elastomers for Tissue Regeneration, G. Rajesh Krishnan, Michael J. Hill, and Debanjan Sarkar
Protein Engineering Strategies for Modular, Responsive, and Spatially Organized Biomaterials, Ian Wheeldon
Tissue and Organ Regeneration
Design and Fabrication of Biomimetic Microvascular Architecture, Thomas M. Cervantes and Joseph P. Vacanti
Tissue Engineering of Human Bladder, Anthony Atala
The Self-Assembly Process of Articular Cartilage and Self-Organization in Tissue Engineering, Pasha Hadidi, Rajalakshmanan Eswaramoorthy, Jerry C. Hu, and Kyriacos A. Athanasiou
Environmental Factors in Cartilage Tissue Engineering, Yueh-Hsun Yang and Gilda A. Barabino
Bone Regenerative Engineering: The Influence of Micro and Nano Dimension, Roshan James, Meng Deng, Sangamesh G. Kumbar, and Cato T. Laurencin
Stem Cell and Bone Regeneration, Martin L. Decaris, Kaitlin C. Murphy, and J. Kent Leach
Notch Signaling Biomaterials and Craniofacial Regeneration, Thanaphum Osathanon, Prasit Pavasant, and Cecilia Giachelli
Stem Cell-Based Dental, Oral and Craniofacial Tissue Engineering, Sahng G. Kim, Chang Hun Lee, Jian Zhou, Mo Chen, Ying Zheng, Mildred C. Embree, Kimi Kong, Karen Song, Susan Y. Fu, Shoko Cho, Nan Jiang, and Jeremy J. Mao
Engineering Functional Bone Grafts for Craniofacial Regeneration, Pinar Yilgor Huri and Warren L. Grayson
Nanotechnology in Osteochondral Regeneration, Nathan J. Castro, Joseph R. O’Brien, and Lijie Grace Zhang
Aortic Heart Valve Tissue Regeneration, Bin Duan, Laura A. Hockaday, Kevin H. Kang, and Jonathan T. Butcher
Micro and Nanotechnology in Vascular Regeneration, Vivian Lee and Guohao Dai
Micro- and Nanofabrication Approaches to Cardiac Tissue Engineering, Nicole Trosper, Petra Kerscher, Jesse Macadangdang, Daniel Carson, Elizabeth Lipke, and Deok-Ho Kim
Engineering of Skeletal Muscle Regeneration: Principles, Current State and Challenges, Weining Bian, Mark Juhas, and Nenad Bursac
Lijie Grace Zhang is assistant professor in the Department of Mechanical and Aerospace Engineering and the Department of Medicine at the George Washington University, USA. She is also director of the Bioengineering Laboratory for Nanomedicine and Tissue Engineering at the university.
Ali Khademhosseini is associate professor at the Harvard–MIT Division of Health Sciences and Technology, Brigham and Women’s Hospital, and Harvard Medical School as well as associate faculty at the Wyss Institute for Biologically Inspired Engineering, Harvard University, USA. He is also junior principal investigator at the World Premier International—Advanced Institute for Materials Research, Tohoku University, Japan, where he directs a satellite laboratory.
Thomas J. Webster is department chair of chemical engineering at Northeastern University, USA. His research explores the use of nanotechnology in numerous applications.
"This practical tour de force will quickly bring you up to speed on the most recent tools and techniques for controlling cellular behavior. With contributions from internationally renowned authors, readers can explore a comprehensive collection of articles tailored for scientists, research engineers, and students to learn basic and advanced micro/nanotechnology protocols. The book helps professionals understand the many intricate steps involved in microenvironmental control in tissue engineering, focusing on state-of-the-art approaches for delivering soluble and substrate-based cues to cells. If you have an interest in tissue engineering or regenerative medicine, this book is a must-have!"
Prof. Jeffrey M. Karp, Brigham and Women's Hospital, USA