Written by experts in the analytical chemistry of tobacco smoke, Tobacco Smoke Exposure Biomarkers summarizes the toxicology, metabolic pathway, and biomarkers of nicotine, TSNAs, PAHs, VOCs, AAs, Catechol and Hydroquinone, HCN, CO and NOx, and heavy metals, and the use of this biomarker in exposure assessment and/or cigarette smoke exposure environmental epidemiology.
A convenient one-stop guide, the book brings together information on some exposure biomarkers and nicotine addiction in humans with regulatory implications and strategies. The authors also include discussions of how smoke exposure biomarkers may be used to shape regulation and health policy. Ethics guidelines, details of method development, and the validated relative bioanalytical method provided in the appendixes rounds out the coverage. The book gives you tools to further research biomarkers for tobacco carcinogens and to face emerging health challenges such as delivery of nicotine via electronic cigarettes.
Table of Contents
Smoking and Health. Biomonitoring and Biomarkers. Biomarkers of Pyridine Alkaloids: Nicotine and Cotinine. Biomarkers of Tobacco-Specific Nitrosamines. Biomarkers of Volatile Organic Compounds. Aromatic Amines. Biomarkers of Catechol and Hydroquinone. Biomarkers of HCN, CO, and NOx Exposure. Biomarkers of Heavy Metal Exposure. Application of Smoke Exposure Biomarker in Epidemiologic Research. Suggestions for the Use of Specific Biomarkers of Exposure to Cigarette Smoke for Regulation Purposes. Appendices.
Dr Qingyuan Hu is the sole representative of the People’s Republic of China to the above mentioned working group. He has attended every Conference of the Parties to WHO/FCTC, from the First Session held in Geneva in 2006. At the Fourth Session, held in Punta del Este in 2010, the Guidelines for Implementation of WHO/FCTC articles 9 and 10 were adopted as "Partial" and "Provisional", as a number of sections were left "intentionally blank", for completion as evidence on tobacco product characteristics including smoke biomarker is generated step-by-step. At the Fifth Session, held in Seoul in 2012, a Background Analysis on addictiveness was presented, which Dr Hu made significant and substantial scientific contributions to.
Dr Hu is also the sole representative of the People’s Republic of China to the WHO Tobacco Laboratory Network (TobLabNet), which comprises 25 laboratories around the world including the US Centers for Disease Control and Prevention (CDC) and the US National Cancer Institute (NCI), both founding members of TobLabNet. Among other tasks, TobLabNet
Finally, Dr Hu is also the sole representative of the People’s Republic of China to the Study Group on Tobacco Product Regulation (TobReg). TobReg is the designated scientific advisory body to WHO on all matters concerning tobacco smoke biomarker.