Tocotrienols : Vitamin E Beyond Tocopherols, Second Edition book cover
2nd Edition

Vitamin E Beyond Tocopherols, Second Edition

ISBN 9781138199729
Published November 16, 2016 by CRC Press
400 Pages 129 B/W Illustrations

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Book Description

The first 90 years of vitamin E research has produced prolific and notable discoveries, but until the last few decades, attention has been given mostly to the biological activities and underlying mechanisms of alpha-tocopherol, which we now know is one of more than eight vitamin E isomers. Currently, the non-tocopherol vitamin E molecule tocotrienol has reached a new measure of research height: more than one-third of all vitamin E tocotrienol research of the last 30 years has been published since 2009. The thriving field of tocotrienol research gives ground for publication of Tocotrienols: Vitamin E Beyond Tocopherols, Second Edition, a compilation of the latest tocotrienol research in all new chapters.


  • Established research, including prevention and treatment of cardiovascular disease, metabolic syndrome, and cancer
  • Emergent research, including angiogenesis, bioavailability, bone health, gastric injury, inflammation, life extension, and skin health
  • Tocopherol interference with tocotrienol functions
  • All new chapters and many new contributors

Recognized as potent antioxidants, tocotrienols play a role in cholesterol reduction, tumor suppression, reversal of arteriosclerosis, and protection of the heart against oxidative stress. Compiling contributions from leading researchers, this book overviews tocotrienols, and examines their sources, chemistry, and mechanisms of action. Contributors discuss the role of tocotrienols in the treatment and prevention of cancer and in cardiovascular health, diabetes, and other hormone regulation by tocotrienols. In addition, the book addresses animal and in vitro as well as mechanistic and pre-clinical studies.

Dr. Tan discusses the benefits of tocotrienol in a YouTube video.

Table of Contents

Tocotrienols in Plants: Occurrence, Biosynthesis, and Function
Maren Müller, Jana Cela, María A. Asensi-Fabado, and Sergi Munné-Bosch
Safety of Unsaturated Vitamin E Tocotrienols and Their Isomers
Alexander G. Schauss, John R. Endres, and Amy Clewell
Bioavailability and Metabolism of Tocotrienols
Zhihong Yang, Mao-Jung Lee, Shengming Sang, and Chung S. Yang
Bioavailability of Tocotrienols and Interference of Their Bioavailability by α-Tocopherol Supplementation
Saiko Ikeda, Tomono Uchida, and Chisato Abe
Alpha-Tocopherol: A Detriment to Tocotrienol Benefits
Anne M. Trias and Barrie Tan
Antiangiogenic Effects of Tocotrienol
Takahiro Eitsuka, Kiyotaka Nakagawa, and Teruo Miyazawa
Mechanism of Delta-Tocotrienol on Colorectal Cancer
Sayori Wada and Yuji Naito
Targeted Prostate Cancer Chemoprevention Trial with Tocotrienols
William L. Stone, Victoria P. Ramsauer, Sharon E. Campbell, and Koymangalath Krishnan
δ-Tocotrienol: Demethylated Vitamin E with Hormetic Function and Therapeutic Application in Breast Cancer
Francesca Pilolli, Marta Piroddi, Elisa Pierpaoli, Silvia Ciffolilli, Mauro Provinciali, and Francesco Galli
Mevalonate-Suppressive Tocotrienols for Cancer Chemoprevention and Adjuvant Therapy
Huanbiao Mo, Manal Elfakhani, Anureet Shah, and Hoda Yeganehjoo
Potential of Tocotrienols in Lung Cancer
Xiangming Ji, Arvind Goja, and Smiti V. Gupta
Tocotrienols and Atherosclerosis: Potential in Cardioprotection
Hapizah Mohd Nawawi
Tocotrienols: Viable Options for Managing Metabolic Diseases
Chi-Wai Wong
Tocotrienols as Possible Treatments for Obesity
Wong Weng-Yew and Lindsay Brown
Tocotrienols, Inflammation, and Cancer: How Are They Linked?
Sahdeo Prasad, Bokyung Sung, Sridevi Patchva, Subash C. Gupta, and Bharat B. Aggarwal
1-Modulating NF-κB Activity by Tocotrienols
Mary Kaileh and Ranjan Sen
Antioxidant Action of Tocotrienols
Etsuo Niki
Tocotrienol in Human Pancreatic Cancer
Mokenge P. Malafa and Kazim Husain
Tocotrienols in the Treatment of Dyslipidemia
Mark Houston
Tocotrienols and Vascular Effects
Aida Hanum Ghulam Rasool
Prolongevity Effects of Tocotrienols: Trials in Caenorhabditis elegans
Noriko Kashima, Yukiko Fujikura, Tomomi Komura, Yoshikazu Nishikawa, Keiji Terao, and Barrie Tan
Anti-Tyrosinase Activity of Tocotrienol in Skin Blemishes
Daniel Yee Leng Yap
Tocotrienols and Bone Health
Ima Nirwana Soelaiman, Norazlina Mohamed, Ahmad Nazrun Shuid, and Norliza Muhammad
Tocotrienol and Physiology of Reproduction
M.H. Rajikin, N. Mokhtar, A. Chatterjee, and Y.S. Kamsani
Tocotrienol and Tocopherol in Stress-Induced Gastric Mucosal Injury
Nafeeza Mohd Ismail and Ibrahim Abdel Aziz Ibrahim
Structural Modification of Tocotrienols to Improve Bioavailability
Awantika Singh, Philip J. Breen, Sanchita Ghosh, K. Sree Kumar, Kottayil I. Varughese, Peter A. Crooks, Martin Hauer-Jensen, and Cesar M. Compadre

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Barrie Tan is the President of American River Nutrition, Inc. in Hadley, Massachusetts, USA.

Ronald Ross Watson is a Professor in the College of Public Health and School of Medicine at the University of Arizona, Tucson, USA.

Victor R. Preedy is the Director of the Genomics Centre at King's College London, UK.