Tocotrienols: Vitamin E Beyond Tocopherols, Second Edition, 2nd Edition (Paperback) book cover


Vitamin E Beyond Tocopherols, Second Edition, 2nd Edition

Edited by Barrie Tan, Ronald Ross Watson, Victor R. Preedy

CRC Press

400 pages | 129 B/W Illus.

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The first 90 years of vitamin E research has produced prolific and notable discoveries, but until the last few decades, attention has been given mostly to the biological activities and underlying mechanisms of alpha-tocopherol, which we now know is one of more than eight vitamin E isomers. Currently, the non-tocopherol vitamin E molecule tocotrienol has reached a new measure of research height: more than one-third of all vitamin E tocotrienol research of the last 30 years has been published since 2009. The thriving field of tocotrienol research gives ground for publication of Tocotrienols: Vitamin E Beyond Tocopherols, Second Edition, a compilation of the latest tocotrienol research in all new chapters.


  • Established research, including prevention and treatment of cardiovascular disease, metabolic syndrome, and cancer
  • Emergent research, including angiogenesis, bioavailability, bone health, gastric injury, inflammation, life extension, and skin health
  • Tocopherol interference with tocotrienol functions
  • All new chapters and many new contributors

Recognized as potent antioxidants, tocotrienols play a role in cholesterol reduction, tumor suppression, reversal of arteriosclerosis, and protection of the heart against oxidative stress. Compiling contributions from leading researchers, this book overviews tocotrienols, and examines their sources, chemistry, and mechanisms of action. Contributors discuss the role of tocotrienols in the treatment and prevention of cancer and in cardiovascular health, diabetes, and other hormone regulation by tocotrienols. In addition, the book addresses animal and in vitro as well as mechanistic and pre-clinical studies.

Dr. Tan discusses the benefits of tocotrienol in a YouTube video.

Table of Contents

Tocotrienols in Plants: Occurrence, Biosynthesis, and Function

Maren Müller, Jana Cela, María A. Asensi-Fabado, and Sergi Munné-Bosch

Safety of Unsaturated Vitamin E Tocotrienols and Their Isomers

Alexander G. Schauss, John R. Endres, and Amy Clewell

Bioavailability and Metabolism of Tocotrienols

Zhihong Yang, Mao-Jung Lee, Shengming Sang, and Chung S. Yang

Bioavailability of Tocotrienols and Interference of Their Bioavailability by α-Tocopherol Supplementation

Saiko Ikeda, Tomono Uchida, and Chisato Abe

Alpha-Tocopherol: A Detriment to Tocotrienol Benefits

Anne M. Trias and Barrie Tan

Antiangiogenic Effects of Tocotrienol

Takahiro Eitsuka, Kiyotaka Nakagawa, and Teruo Miyazawa

Mechanism of Delta-Tocotrienol on Colorectal Cancer

Sayori Wada and Yuji Naito

Targeted Prostate Cancer Chemoprevention Trial with Tocotrienols

William L. Stone, Victoria P. Ramsauer, Sharon E. Campbell, and Koymangalath Krishnan

δ-Tocotrienol: Demethylated Vitamin E with Hormetic Function and Therapeutic Application in Breast Cancer

Francesca Pilolli, Marta Piroddi, Elisa Pierpaoli, Silvia Ciffolilli, Mauro Provinciali, and Francesco Galli

Mevalonate-Suppressive Tocotrienols for Cancer Chemoprevention and Adjuvant Therapy

Huanbiao Mo, Manal Elfakhani, Anureet Shah, and Hoda Yeganehjoo

Potential of Tocotrienols in Lung Cancer

Xiangming Ji, Arvind Goja, and Smiti V. Gupta

Tocotrienols and Atherosclerosis: Potential in Cardioprotection

Hapizah Mohd Nawawi

Tocotrienols: Viable Options for Managing Metabolic Diseases

Chi-Wai Wong

Tocotrienols as Possible Treatments for Obesity

Wong Weng-Yew and Lindsay Brown

Tocotrienols, Inflammation, and Cancer: How Are They Linked?

Sahdeo Prasad, Bokyung Sung, Sridevi Patchva, Subash C. Gupta, and Bharat B. Aggarwal

1-Modulating NF-κB Activity by Tocotrienols

Mary Kaileh and Ranjan Sen

Antioxidant Action of Tocotrienols

Etsuo Niki

Tocotrienol in Human Pancreatic Cancer

Mokenge P. Malafa and Kazim Husain

Tocotrienols in the Treatment of Dyslipidemia

Mark Houston

Tocotrienols and Vascular Effects

Aida Hanum Ghulam Rasool

Prolongevity Effects of Tocotrienols: Trials in Caenorhabditis elegans

Noriko Kashima, Yukiko Fujikura, Tomomi Komura, Yoshikazu Nishikawa, Keiji Terao, and Barrie Tan

Anti-Tyrosinase Activity of Tocotrienol in Skin Blemishes

Daniel Yee Leng Yap

Tocotrienols and Bone Health

Ima Nirwana Soelaiman, Norazlina Mohamed, Ahmad Nazrun Shuid, and Norliza Muhammad

Tocotrienol and Physiology of Reproduction

M.H. Rajikin, N. Mokhtar, A. Chatterjee, and Y.S. Kamsani

Tocotrienol and Tocopherol in Stress-Induced Gastric Mucosal Injury

Nafeeza Mohd Ismail and Ibrahim Abdel Aziz Ibrahim

Structural Modification of Tocotrienols to Improve Bioavailability

Awantika Singh, Philip J. Breen, Sanchita Ghosh, K. Sree Kumar, Kottayil I. Varughese, Peter A. Crooks, Martin Hauer-Jensen, and Cesar M. Compadre


About the Editors

Barrie Tan is the President of American River Nutrition, Inc. in Hadley, Massachusetts, USA.

Ronald Ross Watson is a Professor in the College of Public Health and School of Medicine at the University of Arizona, Tucson, USA.

Victor R. Preedy is the Director of the Genomics Centre at King's College London, UK.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry
MEDICAL / Nutrition