2nd Edition

Tocotrienols Vitamin E Beyond Tocopherols, Second Edition

Edited By Barrie Tan, Ronald Ross Watson, Victor R. Preedy Copyright 2013
    400 Pages 129 B/W Illustrations
    by CRC Press

    400 Pages 129 B/W Illustrations
    by CRC Press

    The first 90 years of vitamin E research has produced prolific and notable discoveries, but until the last few decades, attention has been given mostly to the biological activities and underlying mechanisms of alpha-tocopherol, which we now know is one of more than eight vitamin E isomers. Currently, the non-tocopherol vitamin E molecule tocotrienol has reached a new measure of research height: more than one-third of all vitamin E tocotrienol research of the last 30 years has been published since 2009. The thriving field of tocotrienol research gives ground for publication of Tocotrienols: Vitamin E Beyond Tocopherols, Second Edition, a compilation of the latest tocotrienol research in all new chapters.


    • Established research, including prevention and treatment of cardiovascular disease, metabolic syndrome, and cancer
    • Emergent research, including angiogenesis, bioavailability, bone health, gastric injury, inflammation, life extension, and skin health
    • Tocopherol interference with tocotrienol functions
    • All new chapters and many new contributors

    Recognized as potent antioxidants, tocotrienols play a role in cholesterol reduction, tumor suppression, reversal of arteriosclerosis, and protection of the heart against oxidative stress. Compiling contributions from leading researchers, this book overviews tocotrienols, and examines their sources, chemistry, and mechanisms of action. Contributors discuss the role of tocotrienols in the treatment and prevention of cancer and in cardiovascular health, diabetes, and other hormone regulation by tocotrienols. In addition, the book addresses animal and in vitro as well as mechanistic and pre-clinical studies.

    Dr. Tan discusses the benefits of tocotrienol in a YouTube video.

    Tocotrienols in Plants: Occurrence, Biosynthesis, and Function
    Maren Müller, Jana Cela, María A. Asensi-Fabado, and Sergi Munné-Bosch
    Safety of Unsaturated Vitamin E Tocotrienols and Their Isomers
    Alexander G. Schauss, John R. Endres, and Amy Clewell
    Bioavailability and Metabolism of Tocotrienols
    Zhihong Yang, Mao-Jung Lee, Shengming Sang, and Chung S. Yang
    Bioavailability of Tocotrienols and Interference of Their Bioavailability by α-Tocopherol Supplementation
    Saiko Ikeda, Tomono Uchida, and Chisato Abe
    Alpha-Tocopherol: A Detriment to Tocotrienol Benefits
    Anne M. Trias and Barrie Tan
    Antiangiogenic Effects of Tocotrienol
    Takahiro Eitsuka, Kiyotaka Nakagawa, and Teruo Miyazawa
    Mechanism of Delta-Tocotrienol on Colorectal Cancer
    Sayori Wada and Yuji Naito
    Targeted Prostate Cancer Chemoprevention Trial with Tocotrienols
    William L. Stone, Victoria P. Ramsauer, Sharon E. Campbell, and Koymangalath Krishnan
    δ-Tocotrienol: Demethylated Vitamin E with Hormetic Function and Therapeutic Application in Breast Cancer
    Francesca Pilolli, Marta Piroddi, Elisa Pierpaoli, Silvia Ciffolilli, Mauro Provinciali, and Francesco Galli
    Mevalonate-Suppressive Tocotrienols for Cancer Chemoprevention and Adjuvant Therapy
    Huanbiao Mo, Manal Elfakhani, Anureet Shah, and Hoda Yeganehjoo
    Potential of Tocotrienols in Lung Cancer
    Xiangming Ji, Arvind Goja, and Smiti V. Gupta
    Tocotrienols and Atherosclerosis: Potential in Cardioprotection
    Hapizah Mohd Nawawi
    Tocotrienols: Viable Options for Managing Metabolic Diseases
    Chi-Wai Wong
    Tocotrienols as Possible Treatments for Obesity
    Wong Weng-Yew and Lindsay Brown
    Tocotrienols, Inflammation, and Cancer: How Are They Linked?
    Sahdeo Prasad, Bokyung Sung, Sridevi Patchva, Subash C. Gupta, and Bharat B. Aggarwal
    1-Modulating NF-κB Activity by Tocotrienols
    Mary Kaileh and Ranjan Sen
    Antioxidant Action of Tocotrienols
    Etsuo Niki
    Tocotrienol in Human Pancreatic Cancer
    Mokenge P. Malafa and Kazim Husain
    Tocotrienols in the Treatment of Dyslipidemia
    Mark Houston
    Tocotrienols and Vascular Effects
    Aida Hanum Ghulam Rasool
    Prolongevity Effects of Tocotrienols: Trials in Caenorhabditis elegans
    Noriko Kashima, Yukiko Fujikura, Tomomi Komura, Yoshikazu Nishikawa, Keiji Terao, and Barrie Tan
    Anti-Tyrosinase Activity of Tocotrienol in Skin Blemishes
    Daniel Yee Leng Yap
    Tocotrienols and Bone Health
    Ima Nirwana Soelaiman, Norazlina Mohamed, Ahmad Nazrun Shuid, and Norliza Muhammad
    Tocotrienol and Physiology of Reproduction
    M.H. Rajikin, N. Mokhtar, A. Chatterjee, and Y.S. Kamsani
    Tocotrienol and Tocopherol in Stress-Induced Gastric Mucosal Injury
    Nafeeza Mohd Ismail and Ibrahim Abdel Aziz Ibrahim
    Structural Modification of Tocotrienols to Improve Bioavailability
    Awantika Singh, Philip J. Breen, Sanchita Ghosh, K. Sree Kumar, Kottayil I. Varughese, Peter A. Crooks, Martin Hauer-Jensen, and Cesar M. Compadre


    Barrie Tan is the President of American River Nutrition, Inc. in Hadley, Massachusetts, USA.

    Ronald Ross Watson is a Professor in the College of Public Health and School of Medicine at the University of Arizona, Tucson, USA.

    Victor R. Preedy is the Director of the Genomics Centre at King's College London, UK.