Tomosynthesis Imaging  book cover
1st Edition

Tomosynthesis Imaging

ISBN 9781138199651
Published March 8, 2017 by CRC Press
257 Pages 5 Color & 259 B/W Illustrations

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Book Description

An innovative, three-dimensional x-ray imaging technique that enhances projection radiography by adding depth resolution, Tomosynthesis Imaging explores tomosynthesis, an emerging limited-angle tomographic imaging technology that is being considered for use in a range of clinical applications, and is currently being used for breast cancer screening and diagnosis. While conventional mammography has been very successful in reducing breast cancer mortality, it is not perfect. A major limitation of mammography is that the recorded image represents the superposition of complex three-dimensional structures in the breast onto a two-dimensional plane, making detection and diagnosis of breast cancer challenging.

Tomosynthesis produces quasi-three-dimensional images that can significantly enhance the visualization of important diagnostic features. This book highlights the flexibility of tomosynthesis systems for new clinical applications, and provides a detailed discussion of the tomosynthesis acquisition process and the impact of physical factors. It explores such topics as acquisition parameters, system components, modeling, image reconstruction algorithms, and system evaluation.

  • Provides in-depth coverage of system design considerations, as well as image reconstruction strategies
  • Describes the current state of clinical applications of tomosynthesis, including imaging of the breast and chest, as well as its use in radiotherapy
  • Illustrates the merits of tomosynthesis imaging and its potential clinical applications in imaging of the breast and chest, as well as for radiation therapy

Divided into five sections, this text delves into the history and development of tomosynthesis. It introduces tomosynthesis imaging, discusses imaging system design considerations, and reviews image reconstruction algorithms that have been developed for tomosynthesis. It also describes system evaluation methodologies, emphasizes current clinical applications, and examines the future direction for tomosynthesis.

Table of Contents

Section I Introduction

The history of tomosynthesis

Mitchell M. Goodsitt

Section II System Design

System design and acquisition parameters for breast tomosynthesis

Stephen J. Glick

Detectors for tomosynthesis

Wei Zhao

Patient dose

Ioannis Sechopoulos

Tomosynthesis with circular orbits

Grant M. Stevens and Norbert J. Pelc

Tomosynthesis system modeling

Ingrid Reiser, Beverly Lau, and Robert M. Nishikawa

Section III Image Reconstruction

Filtered backprojection-based methods for tomosynthesis image reconstruction

Thomas Mertelmeier

Iterative image reconstruction design for digital breast tomosynthesis

Emil Y. Sidky

Section IV System Performance

Fourier-domain methods for optimization of tomosynthesis (NE Q)

Ying (Ada) Chen, Weihua Zhou, and James T. Dobbins III

Spatial-domain model observers for optimizing tomosynthesis

Subok Park

Observer experiments with tomosynthesis

Tony Martin Svahn and Anders Tingberg

Section V Clinical Applications

Clinical applications of breast tomosynthesis

Steven P. Poplack

Chest tomosynthesis

Magnus Båth and Åse Allansdotter Johnsson

Tomosynthesis applications in radiation oncology

Devon J. Godfrey, Lei Ren, Q. Jackie Wu, and Fang-Fang Yin

Future developments in breast tomosynthesis

Martin J. Yaffe, Roberta Jong, and James G. Mainprize


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Ingrid Reiser, PhD, is a research associate (assistant professor) in the Department of Radiology at the University of Chicago. After receiving her PhD in physics from Kansas State University in 2002, she transitioned into medical physics research where she witnessed the presentation of the first breast tomosynthesis images at RSNA 2002 (Radiological Society of North America). Tomosynthesis captivated her interest and she has since investigated many aspects of tomosynthesis imaging, such as computer-aided detection, system modeling, and objective assessment. Her research interests further include image perception and observer performance, as well as tomosynthesis and CT image reconstruction.

Stephen J. Glick, PhD, is a professor of radiology at the University of Massachusetts University Medical School and the director of the Tomographic Breast Imaging Research Laboratory. He earned his PhD from Worcester Polytechnic Institute (WPI) in 1991. Dr. Glick is the author of over 60 journal articles and 100 conference proceedings papers and 8 book chapters. Over the past decade, his research has been focused on 3D breast imaging techniques including digital breast tomosynthesis and breast CT with an emphasis on radiation dose, imaging technique optimization, advanced iterative reconstruction methods, detection studies for lesions and microcalcifications, and photon counting detector CT.


"A comprehensive assessment of the current technology and application of tomosynthesis … the book can be read cover to cover without significant repeated material, but each chapter can be consulted and used as an independent reference on a specific aspect of tomosynthesis imaging. The experience and competence of all of the authors is evident. This is required reading for physicists and radiologists who are interested in learning about the fundamentals of the technology behind the future of diagnostic radiography and mammography."
—John M Sabol, PhD, GE Healthcare, Doody’s Review