This book provides a comprehensive overview of the concept of "Total Exposure Health" and presents details on subject areas which make up the framework. It provides in-depth coverage of the science and technology supporting exposure and risk assessment. This includes advances in toxicology and the "-omics" as well as new techniques for exposure assessment. The book concludes with a discussion on bioethics implications, including ethical considerations related to genetic testing.
- Discusses advances in exposure monitoring
- Presents a systems biology approach to human exposures
- Examines how overall well-being translates to worker productivity
- Considers the link between work-related risk factors and health conditions
- Covers the study of genomics in precision medicine and exposure science
- Explores bioethics in genomic studies
Aimed at the exposure professionals (industrial hygienists, toxicologists, public health, environmental engineers), geneticists, molecular biologists, engineers and managers in the health and safety industry as well as professionals in the public administration field.
Table of Contents
Part 1: Overview and Fundamentals. 1. Introduction. 2. Exposure Science: Current and Future Practice. 3. The Future of Human Work. 4. Precision Health: Barriers and Opportunities for Industry. Part 2: Advances in Toxicology and the –Omics. 5. Epigenome Analysis as a Biosensor. 6. New Approaches for Exposure and Risk Assessment in Occupational Health. 7. Systems Biology: Unraveling Transcriptional Responses to Environmental Mixtures. 8. Metabolomics Approaches to Identify Toxicity Pathways in Biological Systems. 9. Translating Genomic Data to Precision Health. 10. The Gene-Environment Interaction and Computational Genetics. 11. Computational Toxicology. 12. Total Worker Health: A Holistic Approach. Part 3: Advances in Exposure Science. 13. Traditional Approaches to Safety and Health: Differences Between Compliance and Total Exposure. 14. Sampling of Chemical Hazards Using Active and Passive Methods. 15. Defining the Exposome of Workers: A Case Study. 16. An Informatics Ecosystem: Utilizing Exposome Data for Translational Research. Part 4: Bioethics. 17. Bioethics and Precision Health: Little Genes to Big Data. 18. Ethical Considerations for Incidental Findings During Genetic Testing. 19. Genome-wide Polygenic Scores for Common Diseases Identify Individuals with Risk Equivalent to Monogenic Mutations. 20. Base Editing and Other Gene Editing Techniques, Opportunities, and the Need for Robust Mechanisms.
Kirk Phillips is the Vice President and Practice Leader for Health Safety and Environment at LJB Inc. He is an Industrial Hygienist who has been practicing for 30 years and has 19 years of executive experience. As a former bioenvironmental engineer in the US Air Force, he led the Occupational and Environmental Health Programs for the whole Air Force as the Associate Chief for Bioenvironmental Engineering, overseeing 1,900 exposure scientists. He held his Certified Industrial Hygiene license for 20 years while practicing at the field level and has a BS in Aerospace Engineering and an MS in Engineering and Environmental Management. Kirk is regularly asked to speak on Total Exposure Health and has presented at the National Academy of Sciences twice and has keynote speaker at numerous national industrial hygiene and toxicology conferences. Kirk serves on the American Society of Safety Professionals Total Worker Health Task Force and works with Battelle Corporation to assist in delivering Total Exposure Health. Dirk P. Yamamoto is the senior industrial hygienist for Force Health Protection Research at the US Air Force School of Aerospace Medicine in Dayton, Ohio. He retired from the US Air Force as a Lieutenant Colonel, having served as both an electronics engineer and bioenvironmental engineer. Dr. Yamamoto is a certified industrial hygienist, certified safety professional, and is a licensed professional engineer. He also serves the American Industrial Hygiene Association, American Board of Industrial Hygiene, and ABET (Accreditation Board for Engineering and Technology, Inc.). LeeAnn Racz is a bioenvironmental engineer in the US Air Force, having served at bases across the globe. She currently serves as commander of the 1st Special Operations Aerospace Medicine Squadron at Hurlburt Field, Florida. She is a licensed professional engineer, certified industrial hygienist and board-certified environmental engineer. Dr. Racz has authored dozens of refereed journal articles and conference presentations, and has edited five handbooks.