This book provides a comprehensive overview of the concept of "Total Exposure Health" and presents details on several related programs being promoted by various federal and civilian agencies. It provides in-depth coverage of the science and technology supporting exposure and risk assessment. This includes advances in toxicology and the "-omics" as well as new techniques for exposure assessment. The book concludes with a discussion on bioethics implications, including ethical considerations related to genetic testing.
Aimed at engineers and managers in the health and safety industry as well as professionals in the public administration field.
Part 1: Overview and Fundamentals. 1. Introduction. 2. Exposure Science: Current and Future Practice. 3. The Future of Human Work. 4. Precision Health: Barriers and Opportunities for Industry. Part 2: Advances in Toxicology and the –Omics. 5. Epigenome Analysis as a Biosensor. 6. New Approaches for Exposure and Risk Assessment in Occupational Health. 7. Systems Biology: Unraveling Transcriptional Responses to Environmental Mixtures. 8. Metabolomics Approaches to Identify Toxicity Pathways in Biological Systems. 9. Translating Genomic Data to Precision Health. 10. The Gene-Environment Interaction and Computational Genetics. 11. Computational Toxicology. 12. Total Worker Health: A Holistic Approach. Part 3: Advances in Exposure Science. 13. Traditional Approaches to Safety and Health: Differences Between Compliance and Total Exposure. 14. Sampling of Chemical Hazards Using Active and Passive Methods. 15. Defining the Exposome of Workers: A Case Study. 16. An Informatics Ecosystem: Utilizing Exposome Data for Translational Research. Part 4: Bioethics. 17. Bioethics and Precision Health: Little Genes to Big Data. 18. Ethical Considerations for Incidental Findings During Genetic Testing. 19. Genome-wide Polygenic Scores for Common Diseases Identify Individuals with Risk Equivalent to Monogenic Mutations. 20. Base Editing and Other Gene Editing Techniques, Opportunities, and the Need for Robust Mechanisms.
This series presents the fundamentals of emerging issues in environmental and occupational health. It specifically focuses on their impact to human health. With advances in analytical technology, our understanding of environmental health issues has dramatically increased over the past several years. Topics such as drinking water treatment in austere environments, air pollution in urban and developing areas, indoor air quality, and emerging contaminants in wastewater treatment are relevant to today’s researchers and policy makers. Likewise, protection for workers’ health is ever-increasing, and this series addresses the state-of-the-art in topics such as respiratory protection, radiation protection, engineering controls, and management techniques.