Responding to the explosion of advances in the use of biomarkers to efficiently, rapidly, and economically evaluate the health effects of chemical entities, this authoritative reference provides a detailed overview of the theory, development, and practical application of biomarkers in the toxicological, environmental, forensic, and pharmaceutical sciences. Compiling the most recent studies on the generation and utilization of biomarkers for toxicant exposure, environmental and human health risk assessment, occupational safety, drug development, and the detection of biological and chemical warfare agents, this guide supplies numerous examples, figures, tables, and comprehensive reference listings within each chapter to provide the reader with an in-depth understanding of the subject.
Introduction to Toxicologic Biomarkers. Challenges in the Statistical Analysis of Biomarker Data. Biomarkers of Toxicant Exposure. Biomarkers in Environmental Epidemiology. Use of Biomarkers in Health Risk Assessment. Biomarkers of Toxicant Susceptibility. Identification and Use of Biomarkers in Preclinical Toxicologic Safety Assessment. Use of Biomarkers in Clinical Toxicology and Clinical Trials. Regulatory Guidance and Validation of Toxicologic Biomarkers. Use of Biomarkers in Occupational Safety and Health. Toxicogenomic and Toxicoproteomic Approaches for Biomarkers. Biomarkers of Chemical Warfare Agent Exposure. Applications of Biomarkers in Toxic Tort and Forensic Litigation