1st Edition
Toxicology of Essential and Xenobiotic Metals
This book explores how metals like cadmium, mercury, lead, aluminium, manganese, and chromium can harm our health, whether through short-term or long-term exposure. It covers symptoms ranging from immediate nausea to long-term issues like Parkinson's and Alzheimer's diseases. Understanding how these metals interact with our bodies is crucial for identifying their harmful effects. The book, divided into 11 chapters, provides straightforward explanations about how these metals affect our health, making it useful for anyone interested in understanding how metals can impact the environment as well as human and animal health.
Preface
Zebrafish as a Model Organism to Study Manganese Toxicity
Nilda Vargas Barbosa, Sabrina Antunes Ferreira and Matheus Mülling dos Santos
The Influence of Tellurium and Selenium Compounds in Biological Systems and Selenium (Se) and Tellurium (Te) Toxicity
Silvia Vávrová, Eva Struhárňanská, Ján Turňa and Stanislav Stuchlík
Aluminum Toxicity
Marilina de Sautu, Nicolás A. Saffioti and Irene C. Mangialavori
Effect of Metals (Hg, Cd, Pb, Zn, Cr and Cu) on Ruminants
Karise Fernanda Nogara, Queila Gouveia Tavares, Maila Palmeira, Carlos Henrique Milagres Ribeiro and Maity Zopollatto
Mercury Toxicity: A Brief Overview
Juliane Hostert, Maria Eduarda A. Galiciolli, Luíza Siqueira Lima, Júlia Vicentin Souza and Cláudia Sirlene de Oliveira
Lead Neurotoxicity: Interactions with Key Ethanol Metabolizing Enzymes
Miriam B. Virgolini and Michael Aschner
Toxicology of Vanadium with Emphasis on the Central Nervous System
Ifukibot Levi Usende, Funmilayo E. Olopade and James Olukayode Olopade
Toxicity of Aluminum: Analytical, Environmental and Biochemical Aspects
Charles Elias Assmann, Karine Paula Reichert, Valderi Luiz Dressler, Maria Rosa Chitolina Schetinger and Vera Maria Morsch
The Differential Role of Toxic and Essential Metals in Formation and Toxicity of Advanced Glycation End-Products
Anatoly V. Skalny, Michael Aschner, Abel Santamaria, Rongzhu Lu, Joao B. T. Rocha, Svetlana V. Zalavina, Vladimir I. Korchin, Tao Ke and Alexey A. Tinkov
The Importance of Rabenstein’s Reaction in the Toxicity of Methylmercury: What is Missing?
João B. T. Rocha, Marcelo Farina, Pablo A. Nogara and Michael Aschner
Gold: Structure, Reactivity, Biological Activities, and Toxicity
Pablo A. Nogara, Folorunsho B. Omage, Caroline S. Schiavon, Karise F. Nogara, Wilian C. da Rosa, Pamela C. da Rosa and Lisandro von Mühlen
Index
Biography
Dr. João Batista Teixeira da Rocha, born in Rio de Janeiro - Brazil, in 1964, is a biochemistry professor at the Universidade Federal de Santa Maria (UFSM), Brazil. He earned his PhD in 1996 and has since focused on studying how certain chemicals interact with our bodies. His research, spanning over 750 scientific papers, explores the toxicity and potential benefits of simple organoselenium compounds. Rocha's work helps us understand how these compounds affect our health and could lead to new treatments.
Dr. Michael Aschner's research and expertise are in the field of neurobiology and physiology of astrocytes. For the past 30 years, he's focused on how metals like mercury, manganese, and uranium enter and move around in our brains, causing damage. Using different models like worms, cells, and mice, his lab explores brain mechanisms. Dr. Aschner is a professor at Albert Einstein College of Medicine, New York, with over 1000 scientific papers and 100 book chapters.
Dr. Pablo Andrei Nogara, born in Ijuí - Brazil in 1991, is a chemist with expertise in biochemistry. He obtained his degrees at the Federal University of Santa Maria, focusing on organic chemistry and computational methods. Currently, he is a professor at the Federal Institute of Education, Science and Technology Sul-rio-grandense (IFSul). Nogara's research explores the biological effects of mercury and selenium, particularly their interactions with thio- and selenoproteins, applying advanced computational techniques like docking simulations, ADMET properties, and quantum chemistry calculations.
