Toxic injury to the skin in the general population, and particularly in western populations, is on the increase. This is partly due to the expanding number of natural and man-made chemicals present in our everyday environment. The need for a thorough understanding of the skin, and the mechanisms of toxicity therein, has never been more pressing. This benchmark volume provides the latest findings in skin toxicology in one definitive source, and it could not be more timely. Toxicology of the Skin is part of the highly acclaimed Target Organ Toxicology Series-a leading series of reviews written and edited by a panel of internationally renowned experts in their respective fields. Dermatologists and toxicology specialists will find this text indispensable.
Table of Contents
Electron Paramagnetic Resonance Study for Defining the Mechanism of Irritant Dermatitis. Irritant Patch Testing in Atopic Individuals. Quantification of Nonerythematous Irritant Dermatitis. Detergents. Permeability of Skin for Metal Compounds. Irritant Dermatitis: Subthreshhold Irritation. Cytokines and Irritant Dermatitis Syndrome. Assay to Quantify Subjective Irritation Caused by the Pyrethroid Insecticide Alpha-Cypermethrin. Prediction of Skin Corrosivity Using Quantitative Structure-activity Relationships. Contamination and Percutaneous Absorption of Chemicals from Water and Soil. Determining an Occupational Dermal Exposure Biomarker for Atrazine Through Measurement of Metabolites in Human Urine by HPLC-accelerator Mass-spectrometry. Partitioning of Chemicals from Water Into Powdered Human Stratum Corneum (Callus). Dermal Exposure of Hands to Pesticides. Iontophoresis. Penetration and Barrier Creams. Fiber. Novel Topical Agents for Prevention and Treatment of Allergic and Irritant Contact Dermatitis. Allergic Contact Dermatitis: Clinical Considerations. Pharmacology, Toxicology and Immunology of Experimental Contact Sensitizers. Modulation of the Dermal Immune Response by Acute Restraint. Textile-dye Allergic Contact Dermatitis Prevalence. Dose-Response Studies in Guinea Pig Allergy Tests. Operational Definition of Allergic Contact Dermatitis. Predictive Immunotoxicological Risk Assessment. Allergic Contact Dermatitis From Transdermal Systems. Animal Models for Immunologic Contact Urticaria and Nonimmunologic Contact Urticaria. Diagnostic Tests in Dermatology. Wound Healing Products. Issues of Toxicity With Dermatologic Drugs During Pregnancy. Roles of Calcium Ions in Skin Barrier. Nuclear Receptors for Psoralen in Cultured Human Skin Fibroblasts. In Vitro Viability Assays. Dermal Penetration of Calcium Salts and Calcinosis Cutis.
Howard I. Maibach