First Published in 1992. The last decade of the twentieth century has seen an unprecedented advocacy for the preservation of a safe environment, and the prevention of ill-health from toxic chemicals. Human activity, however, is responsible for introducing new toxins into the environment. In order to control competitors for human food sources, an armament of pesticides has been assembled and their widespread and largely uncontrolled application has been permitted. It is only when the health of the population begins to suffer from the effects of these chemicals that the efficacy of their use is questioned. Decision-makers whose roles involve the promotion and control of the environment must look to lessons that can be learnt from biosystems that include animals other than man.

    Toxins and Targets details the way in which organisms from diverse habitats in the plant and animal kingdoms have adapted to handle toxins safely. Part I, on the aquatic environment, highlights the means by which marine organisms have adapted their toxins to be effective in a world of high aqueous solubility and infinite dilution. Part II deals with venomous terrestrial organisms and the mechanisms by which they damage animal cells, and Part III considers the way in which human society attempts to investigate toxicity and to control both synthetic and naturally occurring poisons. The development of a safe environ­ment depends on increased knowledge and novel approaches to solving escalating problems. This book is a step towards this end.

    PARTIAQUATIC ECOSYSTEMS Chapter 1 Dlnoflagellate Toxins In Australian Shellfish Chapter 2 Coneshell Venoms-Synthesis and Packaging Chapter 3 Peptides In the Venom of the Geography Cone, Conus geographus Chapter 4 Coneshell Toxin Genes Chapter 5 Toxins from Sea-Squirts Chapter 6 Poisoning by Blue-Green Algae Chapter 7 Soft Corals and Their Toxins PART II DAMAGE TO ANIMAL CELLS Chapter 8 lmmunotherapy for Cancer-Toxin-Antibody Conjugates Chapter 9 A Tick Toxin Chapter 10 A Cycad Neurotoxln Chapter 11 Clguatera Poisoning Chapter 12 Funnel-Web Spider Toxins Chapter 13 Tetanus Toxin Chapter 14 The Exotoxln of Melloldosls, a Disease of Animals and Man Chapter 15 Two Naturally Occurring Toxins Causing Stock Losses Chapter 16 A Jellyfish Toxin Chapter 17 Snake Venom-Haemostatic Components Chapter 18 A Toxic Protein from the AIDS Virus PART Ill POLLUTION, PEOPLE AND PREVENTION Chapter 19 Toxicity Testing Chapter 20 The Effects of Chloropropanes on Spermatozoa Chapter 21 Blomonltorlng of DNA-Damaging Toxins Chapter 22 Organochlorlnes-Pollutants and Human Carcinogens Chapter 23 Ecotoxlcology


    Dianne Watters, Martin Lavin both Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Brisbane, Australia. David Maguire Division of Defence and Technology, Griffith University, Brisbane, Australia. John Pearn Faculty of Medicine and Department of Child Health, University of Queensland, Royal Children's Hospital Brisbane, Australia.