1st Edition

Translational Medicine The Future of Therapy?

Edited By James Mittra, Christopher-Paul Milne Copyright 2013
    294 Pages 14 B/W Illustrations
    by Jenny Stanford Publishing

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    This book brings together a range of academic, industry and practitioner perspectives on translational medicine (TM) to significantly enhance conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure/resources. In recognition of the various implications TM has for public health policy and commercial innovation, this cutting-edge, interdisciplinary book addresses the major systemic aspects of the field.

    Introduction to Translational Medicine
    James Mittra and Christopher-Paul Milne

    Drivers and Barriers to Translational Medicine
    New Light Through an Old Window? The "Translational Turn" in Biomedical Research — A Historical Perspective
    Alison Kraft
    Translational Medicine: The Industry Perspective
    Christopher-Paul Milne, Christine Kohn
    Drivers and Barriers of Translational Medicine: A Regulatory Perspective
    Partha Roy, Atul Bhattaram, and Shiew Mei Huang
    Developing an Evaluation Model for Translational Medicine Research Programs
    Jim Jackson

    State of the Art in Science and Technology
    Emerging Concepts in Biomarker Discovery: Cancer Immunotherapy and Degenerative Diseases of the Eye as Model Systems
    Robert B. Nussenblatt, and Francesco M. Marincola
    Imaging Biomarkers for Innovative Drug Development: Translation from Bench to Bedside and Back
    Jingsong Wang
    Translational Bioinformatics: Bridging the Biological and Clinical Divide
    Indra Neil Sarkar

    Institutional Dynamics of Translational Medicine
    Exploiting Translational Medicine Through Public–Private Partnerships: A Case Study of Scotland’s Translational Medicine Research Collaboration (TMRC)
    James Mittra
    The Role of the Product Development Partnership as a Translational Mechanism for Delivering Health Solutions in Low-Resource Settings
    Julius Mugwagwa, Rebecca Hanlin, Joanna Chataway, and Lois Muraguri

    Is Translational Medicine the Future of Therapy?
    Christopher-Paul Milne and James Mittra


    James Mittra is a research fellow and lecturer at the ESRC Innogen Centre and Science, Technology and Innovation Studies subject group at the University of Edinburgh. His research and teaching focuses on interdisciplinary approaches to the complex and dynamic ways in which life sciences are affecting the nature and the process of technological and therapeutic innovation within the pharmaceutical and biotechnology sectors. Dr. Mittra has published widely on issues of the strategic management and governance of the life sciences, as well as on mapping new value systems and business models for novel therapies.

    Christopher-Paul Milne is director of research at the Tufts Center for the Study of Drug Development. His current research interests include academic–industry collaborations; disease, demographic, and market access factors in the emerging markets; incentive programs for pediatric studies, orphan products, and neglected diseases; and tracking the progress of new regulatory and research initiatives such as regulatory science, comparative effectiveness research, translational medicine, and personalized medicine. Dr. Milne is also research assistant professor at Tufts University Medical School, member of the editorial board of the Food & Drug Law Journal, and an honorary fellow at the University of Edinburgh.

    "This is a book that should be read by all those aiming to improve the efficiency and effectiveness of translation of science into clinical practice and health outcomes. Unlike other contributions in the field, it takes a holistic approach to the problem and recognises the dynamic nature of demand for as well as supply of health innovation, identifying strategies to integrate the two. This book has been needed for some time, but, with stagnating productivity and ever-increasing economic pressures, never more so than right now."
    —Prof. Iain Gillespie, The University of Edinburgh, UK