Translational Pain Research : From Mouse to Man book cover
1st Edition

Translational Pain Research
From Mouse to Man

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ISBN 9781138116047
Published September 12, 2017 by CRC Press
456 Pages 10 Color & 66 B/W Illustrations

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Book Description

One of the Most Rapidly Advancing Fields in Modern Neuroscience

The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes.

Distinguished Team of International Contributors

In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on:

  • Nociceptor sensitization
  • Muscle nociceptors and metabolite detection
  • Visceral afferents in disease
  • Innovative rodent model for bone cancer pain
  • Highly specific receptor cloning
  • Modular molecular mechanisms relevant to painful neuropathies

This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.

Table of Contents

Painful Multi-Symptom Disorders: A Systems Perspective

C. Richard Chapman

Neurotrophic Factors and Nociceptor Sensitization

Michael P. Jankowski and H. Richard Koerber

The Role of Visceral Afferents in Disease

Julie A. Christianson and Brian M. Davis

Cancer Pain: From the Development of Mouse Models to Human Clinical Trials

Juan Miguel Jimenez Andrade and Patrick Mantyh

Therapeutic Targeting of Peripheral Cannabinoid Receptors in Inflammatory and Neuropathic Pain States

Igor Spigelman

Molecular Strategies for Therapeutic Targeting of Primary Sensory Neurons in Chronic Pain Syndromes

Ichiro Nishimura, Devang Thakor, Audrey Lin, Supanigar Ruangsri, and Igor Spigelman

Transgenic Mouse Models for the Tracing of "Pain" Pathways

Allan I. Basbaum and João M. Bráz

Cytokines in Pain

Veronica I. Shubayev, Kinshi Kato, and Robert R. Myers

Glial Modulation in Pain States: Translation into Humans

Ryan J. Horvath, Edgar Alfonso Romero-Sandoval, and Joyce A. De Leo

On the Role of ATP-Gated P2X Receptors in Acute, Inflammatory, and Neuropathic Pain

Estelle Toulme, Makoto Tsuda, Baljit S. Khakh, and Kazuhide Inoue

Myalgia and Fatigue: Translation from Mouse Sensory Neurons to Fibromyalgia and Chronic Fatigue Syndromes

Alan R. Light, Charles J. Vierck, and Kathleen C. Light

Reflex Autonomic Responses Evoked by Group III and IV Muscle Afferents

Jennifer L. McCord and Marc P. Kaufman

Central Pain as a Thalamocortical Dysrhythmia: A Thalamic Efference Disconnection?

Kerry D. Walton and Rodolfo R. Llinás

What Can Neuroimaging Tell Us about Central Pain?

D.S. Veldhuijzen, F.A. Lenz, S.C. LaGraize, and J.D. Greenspan

Human Brain Imaging Studies of Chronic Pain: Translational Opportunities

A. Vania Apkarian

Consideration of Pharmacokinetic Pharmacodynamic Relationships in the Discovery of New Pain Drugs

Garth T. Whiteside and Jeffrey D. Kennedy

Large Animal Models for Pain Therapeutic Development

Darrell A. Henze and Mark O. Urban

Drug Discovery and Development for Pain

Sandra R. Chaplan, William A. Eckert III, and Nicholas I. Carruthers


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Lawrence Kruger, Distinguished Professor of Neurobiology, University of California, USA

Alan Light, Research Professor of Anesthesiology, University of Utah, USA


As the editors of Translational Pain Research: From Mouse to Man state in their preface, "the study of pain is of enormous human importance for the obvious reason that in the course of a lifetime, few individuals manage to evade disruption of their lives by consequential pain experiences." The book is a comprehensive survey of recent pain research that attempts to bring basic science closer to the bedside. The primary intended audience of the book is academic and pharmaceutical industry researchers. Laboratory animal veterinarians and research technicians will also find it a useful reference…In conclusion, Translational Pain Research is a comprehensive review of current research in an area of vital interest to laboratory animal professionals responsible for programs in experimental pain research. The book is highly technical but a non-specialist would find it difficult, but ultimately rewarding.
--Journal of the American Association for Laboratory Animal Science, September 2010