1st Edition

Translational Pain Research From Mouse to Man

Edited By Lawrence Kruger, Alan R Light Copyright 2010
    456 Pages 10 Color & 66 B/W Illustrations
    by CRC Press

    456 Pages 10 Color & 66 B/W Illustrations
    by CRC Press

    One of the Most Rapidly Advancing Fields in Modern Neuroscience

    The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes.

    Distinguished Team of International Contributors

    In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on:

    • Nociceptor sensitization
    • Muscle nociceptors and metabolite detection
    • Visceral afferents in disease
    • Innovative rodent model for bone cancer pain
    • Highly specific receptor cloning
    • Modular molecular mechanisms relevant to painful neuropathies

    This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.

    Painful Multi-Symptom Disorders: A Systems Perspective

    C. Richard Chapman

    Neurotrophic Factors and Nociceptor Sensitization

    Michael P. Jankowski and H. Richard Koerber

    The Role of Visceral Afferents in Disease

    Julie A. Christianson and Brian M. Davis

    Cancer Pain: From the Development of Mouse Models to Human Clinical Trials

    Juan Miguel Jimenez Andrade and Patrick Mantyh

    Therapeutic Targeting of Peripheral Cannabinoid Receptors in Inflammatory and Neuropathic Pain States

    Igor Spigelman

    Molecular Strategies for Therapeutic Targeting of Primary Sensory Neurons in Chronic Pain Syndromes

    Ichiro Nishimura, Devang Thakor, Audrey Lin, Supanigar Ruangsri, and Igor Spigelman

    Transgenic Mouse Models for the Tracing of "Pain" Pathways

    Allan I. Basbaum and João M. Bráz

    Cytokines in Pain

    Veronica I. Shubayev, Kinshi Kato, and Robert R. Myers

    Glial Modulation in Pain States: Translation into Humans

    Ryan J. Horvath, Edgar Alfonso Romero-Sandoval, and Joyce A. De Leo

    On the Role of ATP-Gated P2X Receptors in Acute, Inflammatory, and Neuropathic Pain

    Estelle Toulme, Makoto Tsuda, Baljit S. Khakh, and Kazuhide Inoue

    Myalgia and Fatigue: Translation from Mouse Sensory Neurons to Fibromyalgia and Chronic Fatigue Syndromes

    Alan R. Light, Charles J. Vierck, and Kathleen C. Light

    Reflex Autonomic Responses Evoked by Group III and IV Muscle Afferents

    Jennifer L. McCord and Marc P. Kaufman

    Central Pain as a Thalamocortical Dysrhythmia: A Thalamic Efference Disconnection?

    Kerry D. Walton and Rodolfo R. Llinás

    What Can Neuroimaging Tell Us about Central Pain?

    D.S. Veldhuijzen, F.A. Lenz, S.C. LaGraize, and J.D. Greenspan

    Human Brain Imaging Studies of Chronic Pain: Translational Opportunities

    A. Vania Apkarian

    Consideration of Pharmacokinetic Pharmacodynamic Relationships in the Discovery of New Pain Drugs

    Garth T. Whiteside and Jeffrey D. Kennedy

    Large Animal Models for Pain Therapeutic Development

    Darrell A. Henze and Mark O. Urban

    Drug Discovery and Development for Pain

    Sandra R. Chaplan, William A. Eckert III, and Nicholas I. Carruthers



    Lawrence Kruger, Distinguished Professor of Neurobiology, University of California, USA

    Alan Light, Research Professor of Anesthesiology, University of Utah, USA

    As the editors of Translational Pain Research: From Mouse to Man state in their preface, "the study of pain is of enormous human importance for the obvious reason that in the course of a lifetime, few individuals manage to evade disruption of their lives by consequential pain experiences." The book is a comprehensive survey of recent pain research that attempts to bring basic science closer to the bedside. The primary intended audience of the book is academic and pharmaceutical industry researchers. Laboratory animal veterinarians and research technicians will also find it a useful reference…In conclusion, Translational Pain Research is a comprehensive review of current research in an area of vital interest to laboratory animal professionals responsible for programs in experimental pain research. The book is highly technical but a non-specialist would find it difficult, but ultimately rewarding.
    --Journal of the American Association for Laboratory Animal Science, September 2010