1st Edition
Translational Pain Research From Mouse to Man
Painful Multi-Symptom Disorders: A Systems Perspective
C. Richard Chapman
Neurotrophic Factors and Nociceptor Sensitization
Michael P. Jankowski and H. Richard Koerber
The Role of Visceral Afferents in Disease
Julie A. Christianson and Brian M. Davis
Cancer Pain: From the Development of Mouse Models to Human Clinical Trials
Juan Miguel Jimenez Andrade and Patrick Mantyh
Therapeutic Targeting of Peripheral Cannabinoid Receptors in Inflammatory and Neuropathic Pain States
Igor Spigelman
Molecular Strategies for Therapeutic Targeting of Primary Sensory Neurons in Chronic Pain Syndromes
Ichiro Nishimura, Devang Thakor, Audrey Lin, Supanigar Ruangsri, and Igor Spigelman
Transgenic Mouse Models for the Tracing of "Pain" Pathways
Allan I. Basbaum and João M. Bráz
Cytokines in Pain
Veronica I. Shubayev, Kinshi Kato, and Robert R. Myers
Glial Modulation in Pain States: Translation into Humans
Ryan J. Horvath, Edgar Alfonso Romero-Sandoval, and Joyce A. De Leo
On the Role of ATP-Gated P2X Receptors in Acute, Inflammatory, and Neuropathic Pain
Estelle Toulme, Makoto Tsuda, Baljit S. Khakh, and Kazuhide Inoue
Myalgia and Fatigue: Translation from Mouse Sensory Neurons to Fibromyalgia and Chronic Fatigue Syndromes
Alan R. Light, Charles J. Vierck, and Kathleen C. Light
Reflex Autonomic Responses Evoked by Group III and IV Muscle Afferents
Jennifer L. McCord and Marc P. Kaufman
Central Pain as a Thalamocortical Dysrhythmia: A Thalamic Efference Disconnection?
Kerry D. Walton and Rodolfo R. Llinás
What Can Neuroimaging Tell Us about Central Pain?
D.S. Veldhuijzen, F.A. Lenz, S.C. LaGraize, and J.D. Greenspan
Human Brain Imaging Studies of Chronic Pain: Translational Opportunities
A. Vania Apkarian
Consideration of Pharmacokinetic Pharmacodynamic Relationships in the Discovery of New Pain Drugs
Garth T. Whiteside and Jeffrey D. Kennedy
Large Animal Models for Pain Therapeutic Development
Darrell A. Henze and Mark O. Urban
Drug Discovery and Development for Pain
Sandra R. Chaplan, William A. Eckert III, and Nicholas I. Carruthers
Index
Biography
Lawrence Kruger, Distinguished Professor of Neurobiology, University of California, USA
Alan Light, Research Professor of Anesthesiology, University of Utah, USA
As the editors of Translational Pain Research: From Mouse to Man state in their preface, "the study of pain is of enormous human importance for the obvious reason that in the course of a lifetime, few individuals manage to evade disruption of their lives by consequential pain experiences." The book is a comprehensive survey of recent pain research that attempts to bring basic science closer to the bedside. The primary intended audience of the book is academic and pharmaceutical industry researchers. Laboratory animal veterinarians and research technicians will also find it a useful reference…In conclusion, Translational Pain Research is a comprehensive review of current research in an area of vital interest to laboratory animal professionals responsible for programs in experimental pain research. The book is highly technical but a non-specialist would find it difficult, but ultimately rewarding.
--Journal of the American Association for Laboratory Animal Science, September 2010
