Transport Processes in Pharmaceutical Systems: 1st Edition (Paperback) book cover

Transport Processes in Pharmaceutical Systems

1st Edition

Edited by Gordon L. Amidon, Ping I. Lee, Elizabeth M. Topp

CRC Press

748 pages

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Description

This cutting-edge reference clearly explains pharmaceutical transport phenomena, demonstrating applications ranging from drug or nutrient uptake into vesicle or cell suspensions, drug dissolution and absorption across biological membranes, whole body kinetics, and drug release from polymer reservoirs and matrices to heat and mass transport in freeze-drying and hygroscopicity.

Focuses on practical applications of drug delivery from a physical and mechanistic perspective, highlighting biological systems.

Written by more than 30 international authorities in the field, Transport Processes in Pharmaceutical Systems

  • discusses the crucial relationship between the transport process and thermodynamic factors

  • analyzes the dynamics of diffusion at liquid-liquid, liquid-solid, and liquid-cultured cell interfaces

  • covers prodrug design for improving membrane transport

  • addresses the effects of external stimuli in altering some natural and synthetic polymer matrices

  • examines properties of hydrogels, including synthesis, swelling degree, swelling kinetics, permeability, biocompatibility, and biodegradability

  • presents mass transfer of drugs and pharmacokinetics based on mass balance descriptions

  • and more!

    Containing over 1000 references and more than 1100 equations, drawings, photographs, micrographs, and tables, Transport Processes in Pharmaceutical Systems is a must-read resource for research pharmacists, pharmaceutical scientists and chemists, chemical engineers, physical chemists, and upper-level undergraduate and graduate students in these disciplines.

  • Table of Contents

    Introduction to Transport Processes

    Principles of Mass Transfer

    Elizabeth M. Topp

    Analytical Solutions to Mass Transfer

    Lawrence X. Yu and Gordon L. Amidon

    Pharmacokinetics: Model Structure and Transport Systems

    James M. Gallo

    Experimental Methods to Evaluate Diffusion Coefficients and Investigate Transport Processes of Pharmaceutical Interest

    John W. Mauger

    Dissolution of Pharmaceuticals in Simple and Complex Systems

    Daniel P. McNamara, Michael L. Vieira, and John R. Crison

    Biological Transport Processes

    Biological Transport Phenomena in the Gastrointestinal Tract: Cellular Mechanisms

    David Fleisher

    Improving Oral Drug Transport via Prodrugs

    Mandana Asgharnejad

    Quantitative Approaches to Delineate Passive Transport Mechanisms in Cell Culture Monolayers

    Norman F. H. Ho, Thomas J. Raub, Phillip S. Burton, Craig L. Barsuhn, Anthony Adson, Kenneth L. Audus, and Ronald T. Borchardt

    Barriers to Drug Transport in Ocular Epithelia

    Uday B. Kompella and Vincent H. L. Lee

    Predicting Oral Drug Absorption in Humans

    Lawrence Yu, Larry Gatlin, and Gordon L. Amidon

    Transport Processes in Polymer Systems

    Controlled Release Osmotic Drug Delivery Systems for Oral Applications

    John R. Cardinal

    Transport in Polymer Systems

    Jim H. Kou

    Synthesis and Properties of Hydrogels Used for Drug Delivery

    Stevin H. Gehrke

    Stimuli-Modulated Delivery Systems

    Sung Wan Kim and You Han Bae

    Properties of Solids that Affect Transport

    Manesh J. Nerurkar, Sarma Duddu, David J. W. Grant, and J. Howard Rytting

    Heat and Mass Transport

    Heat and Mass Transfer in Low Pressure Gases: Applications to Freeze Drying

    Michael J. Pikal

    Heat and Mass Transport: Hygroscopicity

    James Wright

    About the Editors

    Gordon L. Amidon, Ping I. Lee, Elizabeth M. Topp

    Subject Categories

    BISAC Subject Codes/Headings:
    SCI013000
    SCIENCE / Chemistry / General
    SCI013060
    SCIENCE / Chemistry / Industrial & Technical