1st Edition

Trends and Future Perspectives in Peptide and Protein Drug Delivery

    392 Pages
    by CRC Press

    Peptide and protein drug delivery research has been moving at a brisk pace for over 10 years. This is the fourth volume in the Drug Targeting and Delivery book series is a collection of selected snapshots of the major past and future developments in this exciting field as seen by over 20 invited speakers at a three-day conference on protein drug delivery held on 2-4 September 1995 in Kyoto, Japan. The wide-ranging topics examined included polymeric delivery systems for protein drugs, means of enhancement of protein drug transport, protein modification for improved pharmacokinetic/pharmacodynamic properties, targeting of peptide and protein drugs, and delivery of oligonucleotidcs and genes.

    Introduction to the Series


    List of Contributors

    I. Peptide and Protein Drug Delivery

    Peptide and Protein Drug Delivery: Past, Present and Future

    Vincent H. L. Lee

    II. Polymeric Delivery Systems for Peptide and Protein Drugs

    Controlling Protein Diffusion in Hydrogels

    Nicholas A. Peppas

    Poly(ortho esters) for the Pulsed and Continuous Delivery of Peptides and Proteins

    Jorge Heller, Ann-France Rime, Suchitra S. Rao, Bruce K. Fritzinger and Steve Y. Ng

    New Delivery Systems for Recombinant Proteins—Practical Issues from Proof of Concept to Clinic

    A. J. S. Jones, T. H. Nguyen, J. L. Cleland and R. Pearlman

    III. Transport Enhancement of Peptide and Protein Drugs Across Selected Absorptive Barriers

    Penetration Enhancement of Peptide Drugs: Palmitoyl Derivatives of Insulin and a Transition-state Mimic Tripeptide Inhibitor of HIV Protease as a Potential Anti-AIDS Drug for Oral Administration

    Yoshiaki Kiso

    Penetration Enhancement of Peptide and Protein Drugs by Electrochemical Means: Transdermal Iontophoresis

    Michael J. Pikal

    Technological and Development Issues of Iontophoretic Transport of Peptide and Protein Drugs

    Burton H. Sage, Jr., C. Randolph Bock, John D. Denuzzio and Randal A. Hoke

    Enhancement of Transferrin Receptor-medicated Transcytosis for Transepithelial Protein Delivery

    Wei-Chiang Shen, Deven Shah, Mitchell E. Taub and Jiansheng Wan

    Peptide Delivery across the Blood — Brain Barrier

    Akira Tsuji

    IV. Modification of Peptide and Protein Drugs for Improved Pharmacokinetic/Pharmacodynamic Properties

    Improved Circulation Half-Life of Proteins Using Deletion Mutants

    Tim J. Ahern

    Pathophysiology of Reactive Oxygen Species: Analysis by Targeting SOD

    Masayasu Inoue, Keiko Koyama and Mitsuru Hashida

    V. Targeting of Peptide and Protein Drugs

    Targeting: From Proteins to Genes

    R. L. Juliano, Jeffery Hughes, Michael Fisher, Anna Avrutskaya, Yoko Shoji and Saghir Akhtar

    (Protein)-Targeted Delivery with Particulate Systems

    Daan J. A. Crommelin, James N. Herron and Gert Storm

    Vascular Targeting as a New Approach to the Therapy of Solid Tumors: Validation in a Mouse Tumor Model

    Philip E. Thrope and Francis J. Burrows

    Recombinant DNA Vaccines: Use of Escherichia coli Envelop Proteins as Tools for Cellular and Molecular Targeting of Foreign Polypeptides in Bacteria and Protein Purification

    J. M. Clément, C. Leclerc, R. Lo-Man, P. Martineau, A. Charbit, S. Szmelcman and M. Hofnung

    Targeting of Proteins in the Brain following Release from a Polymer

    Christine E. Krewson and W. Mark Saltzman

    VI. Delivery of Oligonucleotides and Genes

    Oligonucleotides as Potential Therapeutic Agents

    Stanley T. Crooke

    Liposomal DNA Delivery

    Kyonghee Son and Leaf Huang

    Gene Introduction into Animal Tissues

    Mahito Nakanishi, Ken-ichi Ashihara, Takao Senda, Toru Kondo, Keiko Kato and Tadanori Mayumi

    Systematic Delivery of Recombinant Proteins by Genetically Engineered Myoblasts

    Jyotsna Dhawan and Helen M. Blau



    Vincent H, L, Lee is Gavin S. Herbert Professor and Chairman of the Department of Pharmaceutical Sciences in the School of Pharmacy of the University of Southern California, where he has taught since 1979. Mitsuru Hashida is Professor of Pharmaceutical and Drug Delivery Research in the Faculty of Pharmaceutical Sciences at Kyoto University, from where he received his 8.S., M.S. and Ph.D. degrees in 1974, 1976 and 1979 respectively. Yutaka Mizushima is a Professor of Medicine and Founding Director of the Institute of Medical Science at St. Marianna University.