Trends and Future Perspectives in Peptide and Protein Drug Delivery
Preview
Table of Contents
Introduction to the Series
Preface
List of Contributors
I. Peptide and Protein Drug Delivery
Peptide and Protein Drug Delivery: Past, Present and Future
Vincent H. L. Lee
II. Polymeric Delivery Systems for Peptide and Protein Drugs
Controlling Protein Diffusion in Hydrogels
Nicholas A. Peppas
Poly(ortho esters) for the Pulsed and Continuous Delivery of Peptides and Proteins
Jorge Heller, Ann-France Rime, Suchitra S. Rao, Bruce K. Fritzinger and Steve Y. Ng
New Delivery Systems for Recombinant Proteins—Practical Issues from Proof of Concept to Clinic
A. J. S. Jones, T. H. Nguyen, J. L. Cleland and R. Pearlman
III. Transport Enhancement of Peptide and Protein Drugs Across Selected Absorptive Barriers
Penetration Enhancement of Peptide Drugs: Palmitoyl Derivatives of Insulin and a Transition-state Mimic Tripeptide Inhibitor of HIV Protease as a Potential Anti-AIDS Drug for Oral Administration
Yoshiaki Kiso
Penetration Enhancement of Peptide and Protein Drugs by Electrochemical Means: Transdermal Iontophoresis
Michael J. Pikal
Technological and Development Issues of Iontophoretic Transport of Peptide and Protein Drugs
Burton H. Sage, Jr., C. Randolph Bock, John D. Denuzzio and Randal A. Hoke
Enhancement of Transferrin Receptor-medicated Transcytosis for Transepithelial Protein Delivery
Wei-Chiang Shen, Deven Shah, Mitchell E. Taub and Jiansheng Wan
Peptide Delivery across the Blood — Brain Barrier
Akira Tsuji
IV. Modification of Peptide and Protein Drugs for Improved Pharmacokinetic/Pharmacodynamic Properties
Improved Circulation Half-Life of Proteins Using Deletion Mutants
Tim J. Ahern
Pathophysiology of Reactive Oxygen Species: Analysis by Targeting SOD
Masayasu Inoue, Keiko Koyama and Mitsuru Hashida
V. Targeting of Peptide and Protein Drugs
Targeting: From Proteins to Genes
R. L. Juliano, Jeffery Hughes, Michael Fisher, Anna Avrutskaya, Yoko Shoji and Saghir Akhtar
(Protein)-Targeted Delivery with Particulate Systems
Daan J. A. Crommelin, James N. Herron and Gert Storm
Vascular Targeting as a New Approach to the Therapy of Solid Tumors: Validation in a Mouse Tumor Model
Philip E. Thrope and Francis J. Burrows
Recombinant DNA Vaccines: Use of Escherichia coli Envelop Proteins as Tools for Cellular and Molecular Targeting of Foreign Polypeptides in Bacteria and Protein Purification
J. M. Clément, C. Leclerc, R. Lo-Man, P. Martineau, A. Charbit, S. Szmelcman and M. Hofnung
Targeting of Proteins in the Brain following Release from a Polymer
Christine E. Krewson and W. Mark Saltzman
VI. Delivery of Oligonucleotides and Genes
Oligonucleotides as Potential Therapeutic Agents
Stanley T. Crooke
Liposomal DNA Delivery
Kyonghee Son and Leaf Huang
Gene Introduction into Animal Tissues
Mahito Nakanishi, Ken-ichi Ashihara, Takao Senda, Toru Kondo, Keiko Kato and Tadanori Mayumi
Systematic Delivery of Recombinant Proteins by Genetically Engineered Myoblasts
Jyotsna Dhawan and Helen M. Blau
Index
Author(s)
Biography
Lee, Vincent