Trends and Future Perspectives in Peptide and Protein Drug Delivery  book cover
1st Edition

Trends and Future Perspectives in Peptide and Protein Drug Delivery

ISBN 9783718656417
Published February 1, 1995 by CRC Press
392 Pages

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Table of Contents

Introduction to the Series


List of Contributors

I. Peptide and Protein Drug Delivery

Peptide and Protein Drug Delivery: Past, Present and Future

Vincent H. L. Lee

II. Polymeric Delivery Systems for Peptide and Protein Drugs

Controlling Protein Diffusion in Hydrogels

Nicholas A. Peppas

Poly(ortho esters) for the Pulsed and Continuous Delivery of Peptides and Proteins

Jorge Heller, Ann-France Rime, Suchitra S. Rao, Bruce K. Fritzinger and Steve Y. Ng

New Delivery Systems for Recombinant Proteins—Practical Issues from Proof of Concept to Clinic

A. J. S. Jones, T. H. Nguyen, J. L. Cleland and R. Pearlman

III. Transport Enhancement of Peptide and Protein Drugs Across Selected Absorptive Barriers

Penetration Enhancement of Peptide Drugs: Palmitoyl Derivatives of Insulin and a Transition-state Mimic Tripeptide Inhibitor of HIV Protease as a Potential Anti-AIDS Drug for Oral Administration

Yoshiaki Kiso

Penetration Enhancement of Peptide and Protein Drugs by Electrochemical Means: Transdermal Iontophoresis

Michael J. Pikal

Technological and Development Issues of Iontophoretic Transport of Peptide and Protein Drugs

Burton H. Sage, Jr., C. Randolph Bock, John D. Denuzzio and Randal A. Hoke

Enhancement of Transferrin Receptor-medicated Transcytosis for Transepithelial Protein Delivery

Wei-Chiang Shen, Deven Shah, Mitchell E. Taub and Jiansheng Wan

Peptide Delivery across the Blood — Brain Barrier

Akira Tsuji

IV. Modification of Peptide and Protein Drugs for Improved Pharmacokinetic/Pharmacodynamic Properties

Improved Circulation Half-Life of Proteins Using Deletion Mutants

Tim J. Ahern

Pathophysiology of Reactive Oxygen Species: Analysis by Targeting SOD

Masayasu Inoue, Keiko Koyama and Mitsuru Hashida

V. Targeting of Peptide and Protein Drugs

Targeting: From Proteins to Genes

R. L. Juliano, Jeffery Hughes, Michael Fisher, Anna Avrutskaya, Yoko Shoji and Saghir Akhtar

(Protein)-Targeted Delivery with Particulate Systems

Daan J. A. Crommelin, James N. Herron and Gert Storm

Vascular Targeting as a New Approach to the Therapy of Solid Tumors: Validation in a Mouse Tumor Model

Philip E. Thrope and Francis J. Burrows

Recombinant DNA Vaccines: Use of Escherichia coli Envelop Proteins as Tools for Cellular and Molecular Targeting of Foreign Polypeptides in Bacteria and Protein Purification

J. M. Clément, C. Leclerc, R. Lo-Man, P. Martineau, A. Charbit, S. Szmelcman and M. Hofnung

Targeting of Proteins in the Brain following Release from a Polymer

Christine E. Krewson and W. Mark Saltzman

VI. Delivery of Oligonucleotides and Genes

Oligonucleotides as Potential Therapeutic Agents

Stanley T. Crooke

Liposomal DNA Delivery

Kyonghee Son and Leaf Huang

Gene Introduction into Animal Tissues

Mahito Nakanishi, Ken-ichi Ashihara, Takao Senda, Toru Kondo, Keiko Kato and Tadanori Mayumi

Systematic Delivery of Recombinant Proteins by Genetically Engineered Myoblasts

Jyotsna Dhawan and Helen M. Blau


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