1st Edition
Understanding Cancer Biology Genetics, Molecular Biology, and Cellular Signaling Pathways
SECTION I INTRODUCTION TO CANCER
1. Cell Division in Multicellular Organisms
Renu Dhara and Sonal Datta
2. Cell Senescence, Immortalization and Cancer Progression
Manjari Dimri and Goberdhan P. Dimri
3. DNA Repair and Genome Integrity
Mayank Chaudhary and Sonal Datta
SECTION II GENETIC ASPECTS OF CANCER
4. Genetic Instability and Cancer
Mayank Chaudhary, Mayank Raj, Manoj Singh, Nidarshana Chaturvedi Parashar, Anil Kumar Sharma, and Sonal Datta
5. Epigenetics and Cancer
Nour El Osmani, Youssef A. Hegazy, and Yvonne Fondufe-Mittendorf
6. The Role of Oncogenes in Cancer Initiation and Progression: Mechanisms and Therapeutic Implications
Sukhpal Singh, Rahul Thakur, Sasanka Chakrabarti, Adesh K. Saini, and Reena V. Saini
SECTION III THE ETIOLOGY OF CANCER
7. Viral Carcinogenesis
Anand Gupta and Anish Poorna T.
8. Chemical Carcinogenesis
Anand Gupta and Viraj Nitin Khismatrao
9. Radiation as a Carcinogen
Brenda Isabel Nava and Shyam Sabat
10. Understanding Cancer and Its Broad Classification
Revati Sabat, Mayank Chaudhary, Nidarshana Chaturvedi, Anil Kumar Sharma, and Sonal Datta
SECTION IV SIGNALING PATHWAYS IN CANCER
11. The Role of Growth Factors and Cytokines in Cancer: Insights Into Cell Signaling Pathways
Sandeep Kumar, Shubham, and Pradip Sen
12. Apoptosis in Cancer: Current Paradigms and Future Relevance
Vikas Kushwaha, Varruchi Sharma, Anuprabha, Imran Sheikh, Anil Panwar, Qutsia Tabasum, Amit Joshi, Sonal Datta, Anupam Sharma, Seema Ramniwas, and Anil K. Sharma
13. The Role of Autophagy in Cancer
Shivani Sahu, Ankita Sharma, and Sonal Datta
14. Role of Telomerase and Immortalization
Nidarshana Chaturvedi Parashar, Gaurav Parashar, Amita Dubey, Shaifali Pal, and Renuka
15. Deciphering the Dynamics of Hypoxia, Cancer and Antioxidant Defense Mechanism
Rahul Thakur, Sukhpal Singh, Reena V. Saini, and Adesh K. Saini
16. Metastasis, Invasion, and Tumor Dormancy
N. L. Koustubha and Sonal Datta
17. Cancer Stem Cells: Therapeutic and Regenerative Innovations
Subodh Kumar, Tanishka Aggarwal, Sachin Kumar, Ratnesh Kanwar, Kajal Bhadouria, and Yogesh Kumar Verma
SECTION V CANCER AND TUMOR MICROENVIRONMENT
18. Cellular Immunity in Cancer: Role in Protection and Progression
Raghwendra Pratap Singh, Priya Biswas, and Rashmi Kumar
19. Tumor Microenvironment: Its Role in Cancer Progression and Metastasis
Deepali Aggarwal, Shivani Sahu, and Sonal Datta
20. Angiogenesis and Cancer Biology: A Promising Drug Target
Shallu Saini, Ujjawal Sharma, Bunty Sharma, Ambrish Mishra, Laxmipriya Jena, Rakesh Pahwa, and Hardeep Singh Tuli
SECTION VI CANCER DIAGNOSTIC AND CANCER TREATMENT
21. Diagnosis of Cancer
Anand Gupta and Viraj Nitin Khismatrao
22. Surgical Interventions in Cancer
Anand Gupta and Anish Poorna T.
23. Chemotherapy
Payal Malhotra and Gauri Kapoor
24. The Biological Effects of Chemotherapy on Cancer Cells
Prasad Vasanth and Gauri Kapoor
25. Basics of Radiotherapy
Parveen Ahlawat, Sarthak Tandon, and Munish Gairola
26. The Biological Effect of Radiotherapy on Cancer Cells
Anjali K. Pahuja
27. Immunotherapy and Other Emerging Treatment Options
Ekta Sharma, Tania Dadwal, Nancy Garg, Adesh K. Saini, and Reena V. Saini
28. Newer Antibodies to Treat Cancer
Renu Poria, Desmond Lutomia, Ankur Kaushal, and Shagun Gupta
SECTION VII ADVANCES IN CANCER BIOLOGY
29. Molecular Profiling in Cancer Research and Personalized Medicine
Aditi Sharma, Karanpreet Bhutani, and Reena V. Saini
30. Proteomics and Metabolomics Application in Cancer
Usha, Deepali Chaudhary, Shagun Gupta, and Ankur Kaushal
31. Cancer Systems Biology: From Molecular Profiles to Pathways, Signaling Networks, and Therapeutic Targets
Varruchi Sharma, Imran Sheikh, Anil Panwar, Anuprabha, Qutsia Tabasum, Amit Joshi, Vikas Kushwaha, Sonal Datta, Anupam Sharma, Priyancka Arora, and Anil K. Sharma
32. Emerging Role of the Microbiome in Cancer Progression and Therapeutic Implications
Deepika Pateriya and Vineet K. Sharma
Biography
Sonal Datta is a cancer biologist and protein engineer, currently a Professor in the Department of Bio-Sciences and Technology at Maharishi Markandeshwar (Deemed to be University) [MM(DU)], Mullana, Ambala, Haryana, India. She received her PhD from the Dr. B. R. Ambedkar Center for Biomedical Research at the University of Delhi, India. She was a visiting scientist at the Evanston Northwestern Healthcare Research Institute, Evanston, USA, and the University of Alabama at Birmingham, USA. Dr. Datta has published high-impact articles and book chapters. She has developed novel biosimilar and biobetter therapeutics.
Anil K. Sharma is a Professor and Dean at Amity University, Mohali, Punjab, India. He received his PhD from PGIMER, Panjab University, India. He was a visiting scientist at the University of Illinois, Chicago, USA. He has over 300 publications, an h-index of 45, 17 books, 17 patents, and numerous awards. Dr. Sharma has guided 12 PhD scholars and has been featured in Stanford University’s list of the top 2% of highly cited researchers globally.
Reena V. Saini is a cancer biologist working as a Professor in the Department of Bio-Sciences and Technology at MM(DU). She received her PhD from Dr. B. R. Ambedkar Center for Biomedical Research at the University of Delhi, India, and was a postdoctoral fellow at the NCI, National Institutes of Health, USA. She has published over 120 articles in reputed journals and book chapters.
Adesh K. Saini is the Director of the Research and Development Cell and a Professor in the Department of Bio-Sciences and Technology at MM(DU). He received his PhD from the Dr. B. R. Ambedkar Center for Biomedical Research at the University of Delhi, India, and was a postdoctoral fellow at the NICHD, National Institutes of Health, USA. He has published over 150 articles and 70 patents. He is on Stanford University’s list of the top 2% of highly cited researchers globally with an h-Index of 50.
