Understanding Radiation Biology: From DNA Damage to Cancer and Radiation Risk, 1st Edition (Paperback) book cover

Understanding Radiation Biology

From DNA Damage to Cancer and Radiation Risk, 1st Edition

By Kenneth Chadwick

CRC Press

264 pages | 207 B/W Illus.

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Description

This book provides a qualitative and quantitative exploration of the action of radiation on living matter which leads to a complete and coherent interpretation of radiation biology. It takes readers from radiation-induced molecular damage in the nucleus of the cell and links this damage to cellular effects such as cell killing, chromosome aberrations, and mutations before exploring organ damage, organism lethality, and cancer induction. It also deals with radiological protection concepts and the difficulties of predicting the dose effect relationship for low dose and dose rate radiation risk. The book ends with separate chapters dealing with the effects of UV light exposure and risk classification of chemical mutagens, both of which are derived by logical extensions of the radiation model. This book will provide the basic foundations of radiation biology for undergraduate and graduate students in medical physics, biomedical engineering, radiological protection, medicine, radiology and radiography.

Features:

  • Presents a comprehensive insight into radiation action on living matter
  • Contains important implications for radiological protection and regulations
  • Provides analytical methods for applications in radiotherapy

Dr K H Chadwick, now retired, worked as a research scientist in the Netherlands before moving to Belgium to manage research contracts on radiation biological effects in the Euratom Radiation Protection Research Programme of the European Commission in Brussels. He also served on the editorial board of the Journal for Radiological Protection for ten years and is a fellow of the Institute of Physics (FInst P) and the Society for Radiological Protection (FSRP).

Table of Contents

1. The Molecular Model and DNA Double Strand Breaks. 2. The Molecular Model for Cellular Effects. 3. The Link from Molecular Lesion to Cellular Effects. 4. DNA Double Strand Breaks and Chromosomal Aberrations. 5. 5 The Effect of Dose Rate, Fractionation and Post-irradiation Repair. 6. Radiation Quality. 7. Radiation-Induced Cancer. 8. Radiation-Induced Lethality. 9 Radiological Protection. 10. The Molecular Model for the Cytotoxic Action of UV Light. 11. An Assessment of the Risk of Chemical Mutagens.

About the Author

Dr. K. H Chadwick, now retired, worked at the Institute for the Application of Atomic Science in Agriculture at Wageningen in the Netherlands, employed by the European Commission, for over twenty years. Dr. Chadwick worked closely throughout his career with Dr H P Leenhouts, developing a theoretical model to describe the biological and health effects of radiation. In 1985, he moved to Brussels in Belgium to manage research contracts on radiation biological effects in the Euratom Radiation Protection Research Programme of the European Commission. He also served on the editorial board of the journal for Radiological Protection for ten years.

Subject Categories

BISAC Subject Codes/Headings:
MED062000
MEDICAL / Oncology
SCI017000
SCIENCE / Life Sciences / Cytology
SCI049000
SCIENCE / Life Sciences / Biology / Molecular Biology
SCI055000
SCIENCE / Physics