Understanding the Process of Aging: The Roles of Mitochondria: Free Radicals, and Antioxidants, 1st Edition (Hardback) book cover

Understanding the Process of Aging

The Roles of Mitochondria: Free Radicals, and Antioxidants, 1st Edition

Edited by Lester Packer

CRC Press

384 pages

Purchasing Options:$ = USD
Hardback: 9780824717230
pub: 1999-01-12
$290.00
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Description

This innovative reference explores a wide selection of topics associated with aging, providing a solid understanding of the significance and molecular basis of the aging process and charting the course of future research in the area.

Stresses the interplay of mitochondria, mitochondrial DNA, oxidants, and antioxidants!

Featuring the research of over 55 experts in the area, Understanding the Process of Aging

  • covers the functions of nitric oxide and peroxynitrite in mitochondria

  • integrates several views on the role of mitochondria in the development of apoptosis

  • gives a quantitative analysis of mutations of mitochondrial DNA during human aging

  • highlights mitochondrial free radical production

  • introduces new roles of ubiquinone in mitochondrial functions

  • offers new antioxidant-based complementary therapeutic strategies

  • details aspects of intact cells and whole organisms in health and disease

  • and more!

    Featuring over 1800 references, tables, drawings, and photographs, Understanding the Process of Aging benefits nutritionists and dieticians, geriatricians, cell and molecular biologists, chemists and biochemists, pharmacologists, biotechnologists, neurologists, cardiologists, oncologists, dermatologists, and graduate and medical school students in these disciplines.

  • Reviews

    "

    …an important contribution to mechanisms of aging that are often overlooked.

    "-Gerontology

    Table of Contents

    The Mitochondrial Production of Oxygen Radicals and Cellular Aging, Alberto Boveris, Lidia E. Costa, and Enrique Cadenas

    Walking a Tightrope: The Balance Between Mitochondrial Generation and Scavenging of Superoxide Anion, David M. Guidot and Joe M. McCord

    The Biochemistry of Nitric Oxide and Peroxynitrite: Implications for Mitochondrial Function, Rakesh P. Patel, Trudy Cornwell, and Victor M. Darley-Usmar

    Oxygen-Dependent Regulation of Biological Functions by Nitric Oxide, Kozo Utsumi, Yoshiki Takehara, Yoko Inai, Munehisa Yabuki, Tomoko Kanno, Manabu Nishikawa, Eisuke F. Sato, and Masayasu Inoue

    Production of Reactive Oxygen Species in Mitochondria and Age-Associated Pathophysiology: A Reality Check, Henry Jay Forman and Angelo Azzi

    Functional Roles of Ubiquinone, Jeffery R. Schultz and Catherine Freitag Clarke

    Mitochondrial Generation of Reactive Oxygen Species and Oxidative Damage During Aging: Roles of Coenzyme Q and Tocopherol, Rajindar S. Sohal, Achim Lass, Liang-Jun Yan, and Linda K. Kwong

    Mitochondria and Aging: The Mouse's Tale, Steve Esworthy

    Mitochondria and Apoptosis, Bernard M. Babior, Roberta A. Gottlieb, and Christoph Richter

    Role of Mitochondria in Oxidative Stress Associated with Aging and Apoptosis: Studies in Intact Cells, Juan Sastre, Federico V. Pallardó, José García de la Asunción, Miguel A. Asensi, Juan M. Esteve, and José Viña-Ribes

    The Role of Iron and Mitochondria in Aging, Patrick B. Walter, Kenneth B. Beckman, and Bruce N. Ames

    The Mitochondrial-Lysosomal Axis Theory of Cellular Aging, Ulf T. Brunk and Alexei Terman

    Quantitative Analysis of Mutations of Mitochondrial DNA During Human Aging, Jörg Napiwotzki, Annette Reith, Andreas Becker, Sandra Leist, and Bernhard Kadenbach

    Oxidative Damage and Fragility of Mitochondrial DNA, Takayuki Ozawa

    Mitochondria in Cellular Aging and Degeneration, Gino A. Cortopassi and Alice Wong

    Mitochondrial Alteration in Aging and Inflammation: A Possible Site of Action of Nitrone-Based Free Radical Traps, Kenneth Hensley, Lindsay Maidt, C. A. Stewart, Quentin N. Pye, K. A. Robinson, and Robert A. Floyd

    Muscle Mitochondrial Transmembrane Processes in Mitochondriocytopathies, Marjan Huizing, J.M.F. Trijbels, J.A.M. Smeitink, L.P. van den Heuvel, Fernando Palmieri, and Wim Ruitenbeek

    About the Series

    Oxidative Stress and Disease

    Learn more…

    Subject Categories

    BISAC Subject Codes/Headings:
    MED008000
    MEDICAL / Biochemistry
    MED032000
    MEDICAL / Geriatrics
    MED060000
    MEDICAL / Nutrition