Unifying Microbial Mechanisms: Shared Strategies of Pathogenesis, 1st Edition (Paperback) book cover

Unifying Microbial Mechanisms

Shared Strategies of Pathogenesis, 1st Edition

By Michael F. Cole

Garland Science

356 pages | 151 Color Illus. | 17 B/W Illus.

Purchasing Options:$ = USD
Paperback: 9780815345404
pub: 2019-07-10
Available for pre-order
Hardback: 9780367206642
pub: 2019-07-10
Available for pre-order

FREE Standard Shipping!


Microbial pathogenesis is the study of the mechanisms by which microbes (bacteria, viruses, protozoa, and multicellular parasites) cause infectious disease and make their hosts (humans) ill. Bacterial infections we thought were easily treatable are again a huge cause for concern with the well-publicized rise of antibiotic resistance. There are very few effective antiviral drugs and we live with the threat of epidemics such as bird flu and the outbreaks of viruses such the recent (and ongoing) Ebola crisis. Parasitic diseases such as malaria continue to pose a heavy burden in the developing world and with climate change could spread into the developed world. There is therefore an urgent need to understand microbial mechanisms, with research programmes and university courses dedicated to the subject

Table of Contents

1. Introduction to Pathogenesis. 2. Normal Microbiotas of the Human Body. 3. Biofilms. 4. Adhesion to Host Surfaces. 5. Facilitated Cell Entry. 6. Exotoxins and Endotoxins. 7. Hydrolytic Enzymes. 8. Persistent Infections. 9. Evasion of the Human Innate Immune System. 10. Evasion of the Human Adaptive Immune System.

About the Author

Mike Cole is an experienced instructor at Georgetown University where he is professor of microbiology and immunology and teaches microbial pathogenesis, immunology, and bacteriology. His research interests are into the regulation of commensal and pathogenic bacteria at the mucosal surface by the secretory immune response and the ontogeny of the secretory immune system. He regularly attends the ASM education conference and is the author of half the bacterial cases in Case Studies in Infectious Disease.

Subject Categories

BISAC Subject Codes/Headings:
SCIENCE / Life Sciences / Biology / Microbiology
SCIENCE / Life Sciences / General