Using Mass Spectrometry for Drug Metabolism Studies: 2nd Edition (Hardback) book cover

Using Mass Spectrometry for Drug Metabolism Studies

2nd Edition

Edited by Walter A. Korfmacher

CRC Press

451 pages | 12 Color Illus. | 174 B/W Illus.

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pub: 2009-11-03
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Description

The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the field, the emergence of cutting-edge approaches, and ways to meet steadily increasing vendor demands. Written by international scientists who are experts in their respective disciplines, this state-of-the-art reference effectively encapsulates current mass spectrometry best practices.

The stand-alone chapters cover various topics – from metabolite identification to fast chromatography with UPLC – and in a style that is understandable to experts and field newcomers alike. The second edition of this bestseller includes coverage of new instrumentation and software as well as a wealth of updated information on the latest findings surrounding biomarkers and metabolomics and new chapters on both UPLC and DESI/DART.

With more than 180 illustrations and an eight-page color insert, this valuable reference explores multiple modern mass spectrometry techniques and strategies. It includes an excellent overview of the entire drug discovery process plus the latest developments on how mass spectrometry is used to support this endeavor.

Table of Contents

Strategies and Techniques for Bioanalytical Assays as Part of New Drug Discovery, Walter A. Korfmacher

The Drug Discovery Process: From Molecules to Drugs, Mike S. Lee and Steven E. Klohr

PK Principles and PK/PD Applications, Hong Mei and Richard A. Morrison

Mass Spectrometry for In Vitro ADME Screening, Inhou Chu

Metabolite Identification Strategies and Procedures, Ragu Ramanathan, S. Nilgün Çömezog˘ lu, and W. Griffith Humphreys

Reactive Metabolite Screening and Covalent-Binding Assays, Gérard Hopfgartner

Fast Metabolite Screening in a Discovery Setting, Xiaoying Xu

Fast Chromatography with UPLC and Other Techniques, Sam Wainhaus

Supercritical Fluid Chromatography–Mass Spectrometry, Yunsheng Hsieh

Biomarkers of Efficacy and Toxicity: Discovery and Assay, Joanna R. Pols

Imaging Mass Spectrometry for Small Molecules, Fangbiao Li

MALDI IMS for Proteins and Biomarkers, Michelle L. Reyzer and Richard M. Caprioli

Ambient Ionization Methods and Their Early Applications in ADME Studies, Jing-Tao Wu

Pharmaceutical Applications of Accelerator Mass Spectrometry, Lan Gao and Swapan Chowdhury

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
SCI013010
SCIENCE / Chemistry / Analytic
SCI013060
SCIENCE / Chemistry / Industrial & Technical