1st Edition

Vaccine Research and Development Volume 1:

Edited By Wayne C. Koff, Howard R. Six Copyright 1992
    264 Pages
    by CRC Press

    Serving as a complementary series to AIDS Research Reviews - edited by Drs. Wayne C. Koff, Flossie Wong-Staal, and Ronald C. Kennedy (Marcel Dekker, Inc.) - this new series reviews significant advances in immunization research and addresses scientific and public policy challenges for moving candidate vaccines from the laboratory to the population.;Exploring recent progress in immunology, vaccine development and improvement, and clinical trials, Vaccine Research and Developments: analyzes the capacity of lipophilic components to chemically modify peptide and protein antigens and augment their immunogenicity; discusses the potential of noninfectious packaging mutants to serve as prototype vaccines; provides a novel presentation system for peptide vaccines through the multiple antigen peptide approach; examines the current status and future prospects for contraceptive vaccines and offers perspectives for improving pertussis vaccines; furnishes a comprehensive update of vaccine clinical trials; and describes the legal policy aspects involved in developing HIV vaccines.;Containing over 915 useful references, Vaccine Research and Developments is for immunologists, microbiologists and virologists, molecular and cell biologists, infectious disease specialists, pharmacologists, government and industry drug regulatory personnel, and graduate level students in these disciplines.

    Part 1 Technical advances in vaccine development: lipopeptides and their effects on the immune system - use as vaccine components, Patricia J. Freda Pietrobon and Patrick Kanda; HIV-1 virus-like particles as a source of antigen for AIDS vaccines, Anna Aldovini and Richard A. Young; chemically defined synthetic immunogens and vaccines by the multiple antigen peptide approach, James P. Tam; the use of muramyl peptides as vaccine adjuvants, Gary Ott et al. Part 2 Vaccine development - current status/future directions: contraceptive vaccine development - future prospects, Nancy J. Alexander; perspectives in recombinant pertussis toxoid development, W. Neal Burnette. Part 3 Vaccines - clinical and policy development: vaccine clinical trials, John R. La Montagne and George T. Curlin; the development of an HIV vaccine - legal and policy aspects, Robert E. Stein.


    Wayne C. Koff; Howard R. Six