1st Edition

Vanadium
Chemistry, Biochemistry, Pharmacology and Practical Applications




ISBN 9781420046137
Published March 19, 2007 by CRC Press
250 Pages 25 B/W Illustrations

USD $240.00

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Book Description

The first comprehensive resource on the chemistry of vanadium, Vanadium: Chemistry, Biochemistry, Pharmacology, and Practical Applications has evolved from over a quarter century of research that concentrated on delineating the aqueous coordination reactions that characterize the vanadium(V) oxidation state. The authors distill information on biological processes needed to understand vanadium effects in biological systems and make this information accessible to a wide range of readers, including chemists without extensive biological training.

Building a hierarchy of complexity, the book provides a discussion of some basic principles of 51V NMR spectroscopy followed by a description of the self-condensation reactions of vanadate itself. The authors delineate reactions with simple monodentate ligands and then proceed to more complicated systems such as diols, a-hydroxy acids, amino acids, peptides, to name just a few. They revisit aspects of this sequence later, but first highlight the influence the electronic properties of ligands have on coordination and reactivity. They then compare and contrast the influences of ligands, particularly those of hydrogen peroxide and hydroxylamine, on heteroligand reactivity.

The book includes coverage of vanadium-dependent haloperoxidases and model systems, vanadium in the environment, and technological applications. It also briefly covers the catalytic reactions of peroxovanadate and haloperoxidase model compounds. It contains a discussion of the vanadium haloperoxidases and the biological and biochemical activities of vanadium(V) including potential pharmacological applications. The last chapters step outside these boundaries by introducing some aspects of the future of vanadium in nanotechnology, the recyclable redox battery, and the lithium/silver vanadium oxide battery.

Primary sources documented after each chapter minimize the need to search the literature, 80 illustrations provide structural information, reaction schemes, spectra, speciation diagrams, and biochemical schemes, and 22 tables present detailed information with references to primary sources. Packed with current and authoritative information, the book covers chemistry and bioinorganic vanadium chemistry in a broad and systematic manner that engenders comprehensive understanding.

Table of Contents

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INTRODUCTION


Background

VANADATE SPECIATION


Techniques
Vanadate Self-Condensation Reactions
Vanadium Atom Stoichiometry of Complexes

MONODENTATE LIGANDS OF VANADATE


Alcohols and Phenols
Amines and Acids
AQUEOUS REACTIONS OF VANADATE WITH MULTIDENTATE LIGANDS
Glycols, a-Hydroxycarboxylic Acids, and Dicarboxylic Acids
Hydroxamic Acids
Thiolate-Containing Ligands
Amino Alcohols and Related Ligands
Amino Acids and Derivatives
a-Amino Acids and Peptides
Other Multidentate Ligands
COORDINATION OF VANADATE BY HYDROGEN PEROXIDE AND HYDROXYLAMINES
Hydrogen Peroxide
Hydroxylamines
Coordination Geometry of Peroxo and Hydroxamido Vanadates

REACTIONS OF PEROXOVANADATES


Heteroligand Reactions of Bisperoxovanadates
Reactions of Monoperoxovanadates with Heteroligands
Oxygen Transfer Reactions of Peroxovanadates
AQUEOUS REACTIONS AND NMR SPECTROSCOPY OF HYDROXAMIDOVANADATE
Vanadium NMR Spectroscopy of Hydroxamido Complexes

REACTIONS OF OLIGOVANADATES


The Smaller Oligomers
Decavanadate
INFLUENCE OF LIGAND PROPERTIES ON PRODUCT STRUCTURE AND REACTIVITY
Alkyl Alcohols
Glycols, a-Hydroxy Acids, and Oxalate
Bisperoxo and Bishydroxamido Vanadates: Heteroligand Reactivity
Phenols
Diethanolamines
Pattern of Reactivity

VANADIUM IN BIOLOGICAL SYSTEMS


Distribution in the Environment
Vanadium-Ligand Complexes
Vanadium Transport and Binding Proteins
Vanadium Containing Enzymes
THE INFLUENCE OF VANADIUM COMPOUNDS ON BIOLOGICAL SYSTEMS
Vanadium Compounds on Biological Systems: Cellular Growth, Oxidation-Reduction Pathways, and Enzymes Metabolism
Pharmacological Properties of Vanadium
Mechanism of Therapeutic and Apoptotic Effects of Vanadium
Summary
Abbreviations

TECHNOLOGICAL DEVELOPMENT


Molecular Networks and Nanomaterials
The Vanadium Redox Battery
The Silver Vanadium Oxide Battery
PREPARATION, CHARACTERIZATION, AND BATTERY APPLICATIONS OF SILVER VANADIUM OXIDE MATERIALS
Introduction
Preparation, Structure, and Reactivity of Silver Vanadium Oxide and Related Materials
Battery Applications of Silver Vanadium Oxide
Summary
*Each Chapter Contains References

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Reviews

"The first comprehensive resource on the chemistry of vanadium, this book has evolved from over a quarter century of research that concentrated on delineating the aqueous coordination reactions that characterize the vanadium(V) oxidation state . . . make this information accessible to a wide range of readers . . ."

– In Anticancer Research, Sept/ Oct 2007, Vol. 27, No. 5A