Endothelial dysfunction is now regarded as an early marker of vascular disease and therefore an important target for therapeutic intervention and discovery of novel treatments. Ideal for both basic and clinical scientists, whether in industry or academia, and physicians, Vascular Endothelium in Human Physiology and Pathophysiology provides an up-to-date review of the vascular functions of the endothelium and its role in key areas of cardiovascular disease. It focuses on evidence from studies in humans.
1. Endothelial Nitric Oxide 2. The Endothelin System: Physiology 3. Cyclooxygenase-dependent Endothelium-derived Contracting Factors 4. Endothelium-derived Hyperpolarising Factor 5. Regulation of Blood Cell Function by Endothelial Cells 6. Hypertension 7. Endothelial Control of Vascular Tone in Chronic Heart Failure 8. Hypercholesterolaemia, Atherosclerosis and the NO Synthase Pathway 9. Endothelial Function in Diabetes Mellitus 10. Flow-mediated Dilatation and Cardiovascular Risk 11. Endothelial Mediators and Renal Disease 12. Infection and Vascular Inflammation 13. The Endothelium in Human Pregnancy