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Vascular Manifestations of Systemic Autoimmune Diseases: 1st Edition (Hardback) book cover

Vascular Manifestations of Systemic Autoimmune Diseases

1st Edition

Edited by Ronald A. Asherson, Ricard Cervera, Douglas A. Triplett, Steven B. Abramson

CRC Press

624 pages

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Hardback: 9780849313356
pub: 2001-01-25
eBook (VitalSource) : 9780429122712
pub: 2001-01-25
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Not too long ago, it was thought that inflammation of blood vessels was the sole manifestation of systemic autoimmune diseases. Today, however, we know that disorders of coagulation, injuries to both neutrophils and endothelial cells, and certain lipids and amino acids are all intricately involved in the development of vascular disease. How are all these processes linked? What strategies can we employ or develop to halt the progression of vascular damage? What are the best ways to control acute vasculitis and vasospasm therapeutically? What are the risks and benefits of various strategies for the prevention of clotting? How soon should we initiate preventive strategies that protect blood vessels from arteriosclerosis in people with acute rheumatic diseases? What should be the nature of those strategies?

Vascular Manifestations of Systemic Autoimmune Diseases provides answers to all these questions. Ronald Asherson, Richard Cervera,Steven B. Abramson, Jean-Charles Piette, and Douglas Triplett- all international experts in the field-have assembled a collection of works that provide a comprehensive analysis of vascular irregularities. Now that most individuals survive the onset of acute systemic autoimmune diseases and live for decades more, halting the long-term attack on vasculature is increasingly important.

Vascular Manifestations of Systemic Autoimmune Diseases not only describes the clinical symptoms of vascular diseases; it also covers in one volume the many mechanisms involved in the pathogenesis of these disorders and addresses the newest treatments available for them.


"This book integrates the current understanding in the field of the biology underlying these varied vasculitic syndromes with their clinical presentations and the therapeutic strategies used to treat them."

- Deborah Jane Lenschow, MD, PhD, Washington University School of Medicine, Doody's Notes

Table of Contents

Section I: Mechanisms of Vascular Disease

Pathology of Vascular Disease, H. Terence Cook and Charles D. Pusey

Coagulation Abnormalities, Douglas A. Triplett

Antiphospholipid Antibodies, Robert A. S. Roubey

Platelet Disorders in Autoimmune Diseases

Ronit Simantov and Babette B. Weksler

Immunology of Atherosclerosis, Outi Vaarala

Homocysteine and Vascular Disease in the

Autoimmune Connective Tissue Diseases,

Michelle Petri

Vascular Tone Control and Raynaud´s Phenomenon,

Marco Matucci-Cerinic, Sergio Generini, Pan Sheng Fan,and M. Bashar Kahaleh

Antineutrophil Cytoplasmic Antibodies,

Xavier Bosch and Josep Font

Antiendothelial Cell Antibodies, Pier Luigi Moroni, Nicoletta del Papa, Elena Raschi

Cryoglobulins, Mario García-Carrasco, Manel Ramos-Casals, Ricard Cervera, and Josep Font

Markers of Endothelial Damage, David P. D'Cruz

Systemic Inflammatory Response Syndrome,

Systemic Lupus Erythematosus, and

Thrombosis, H. Michael Belmont and Steven B.


Leukocyte Cell Adhesion Molecules in Vasculitis,

Jan Willem Cohen Tervaert, and Cees G. M. Kallenberg

Experimental Induction of Vascular Disease

Ilan Krause, Miri Blank, Yehuda Shoenfeld

Hormones and Vascular Disease, Joan T. Merrill and Robert G. Lahita

Section II: Clinical Manifestations

Vascular Manifestations in Necrotizing and

Granulomatous Vasculitides, Karim Raza, David

M. Carruthers, Paul A. Bacon

Vascular Manifestations in Giant-Cell Arteritis,

María C. Cid, José Hernández-Rodríguez, Josep M. Grau

Vascular Manifestations in Takayasu Arteritis, Fujio Numano

Vascular Manifestations in Systemic Lupus Erythematosus, Josep Font, Ricard Cervera, Miguel Ingelmo

Vascular Manifestations in the Antiphospholipid Syndrome, Ronald A. Asherson and Ricard Cervera

Vascular Manifestations in Sjögren´s Syndrome, Anne Parke

Vascular Manifestations of Progressive Systemic Sclerosis, Christopher P. Denton and Carol M. Black

Vascular Manifestations in Rheumatoid Arthritis,

Dermato/Polymyositis, and Mixed Connective

Tissue Disease, Jean-Charles Piette and Camille


Vascular Manifestations in Relapsing Polychondritis,

Jean-Charles Piette, Philippe Vinceneux, Camille Francès

Vascular Manifestations of Behçet´s Disease, Olcay Aydintug

Vascular Manifestations in Microangiopathic Syndromes, Gale A. McCarty

The Vasculitic Diseases of Childhood, Thomas J. A. Lehman

Pulmonary Hypertension, S.P. Wharton and T.W. Higenbottam

Renal Vasculitis, Michael Samarkos, Sozos Loizou, Kevin A. Davies

Skin Manifestations of Vasculitis,

Camille Francès, Pierre-André Bécherel, Jean-Charles Piette

Section III: Treatment

Pharmacological Treatments for Thrombotic Diseases,

Joan-Carles Reverter, Dolors Tàssies, Gerard Espinosa

Hormone Replacement Therapy for "At Risk"

Patients with Connective Tissue Diseases, Ann


Surgical Treatments, Matthew Waltham and Kevin G. Burnand

Therapy of Systemic Vasculitis, David M. Carruthers, Karim Raza, Paul A. Bacon

Anticoagulation Therapy for the Antiphospholipid Syndrome, Scott Goodnight

The Treatment of Raynaud´s Phenomenon, Marco Martucci Cerinic, Sergio Generini, James R. Seibold

Treatment of Pulmonary Hypertension, S.P. Wharton and T.W. Higenbottam

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Clinical Medicine
MEDICAL / Rheumatology