1st Edition

Vascular Protection Molecular Mechanisms, Novel Therapeutic Principles and Clinical Applications

    482 Pages 31 Color & 16 B/W Illustrations
    by CRC Press

    Vascular Protection explores advances in vascular biology and how they translate into innovations in drug therapy for vascular disease. It addresses recent advances in the knowledge of endothelial vasoactive factors and other biologically active molecules as well as gene therapy. Written by leading experts in their respective fields, each chapter emphasizes the mechanisms and pathologic consequences of vascular disorders, highlighting the clinical ramifications of these insights and the potential for new therapeutic strategies. Vascular Protection provides critical new information for researchers and clinicians, as well as to industrial scientists in pursuit of novel therapies for cardiovascular disorders.

    Endothelium-Derived Vasoactive Factors / Endothelial Dysfunction. "Nitric Oxide Deficiency" in Cardiovascular protection by Restoration of Endothelial Nitric Oxide Production. Sickle Erythrocyte Interaction with Endothelial Cells Causes Endothelial Dysfunction. Uncoupling of Endothelial Nitric Oxide Synthase: A Molecular Basis for Atherosclerosis. Endothelin Receptor Changes Following Angioplasty of Porcine Coronary Effect of the Endothelin-A Receptor Antagonist, LU 135252. A Potential Role for Endothelin-1 Peripheral Vascular Disease. Endurance Exercise Preserves Endothelium Dependent Arterial Dynamics in the Elderly. Effect of AT1-Receptor Antagonists on Endothelial Function. "No Touch" Technique Harvesting Saphenous Vein with its Surrounding Tissue for Coronary Artery Bypass Surgery Provides an Intact Endthelium and a High Mid-Term Patency Rate. Intracellular Signaling in Vascular Cells. NO Signaling in Blood Vessels. Ca2+independent Nitric Oxide Synthase Activation in Endothelial Cells. Adhesion Molecules in Diabetic Vasculopathy. Regulation NF-kB in Vascular Smooth Muscle Cells. Flow-Mediated Activation of MAP Kinases. Apoptosis and Vascular Remodeling. The Role of Intimal Cells in Atherosclerosis. Macrophage Resistance to Apoptosis in Vascular Diseases. Cytokines in Endothelial Cell Survival and Apoptosis: A Role for Protein Kinases and Caspases.Altered Mitotic Checkpoint in Rats Predisposed to Hypertension. Innervation of the Pig Vein Graft: A Potential for Vascular Nerves on Graft Occlusion. Sex Hormones and Vascular Protection. Estrogen Receptor Knockout Mice: Molecular and Endocrine Phenotypes. The Potential Role of Estrogen Receptor Alpha (ERa) in Cardiovascular Protection. Differential Effects of Estrogen on the Initiation and Progression of Atherosclerotic Lesions in Hypercholesterolemic Animal Models. Protective Effects of Estrogen on Global Myocardial Ischemia-Reperfusion Injury in Males and Females. The Estrogen in Women with Athersclerosis Study: Effects of Hormone Replacement Therapy on Plasma Concentrations of Lp(a) Lipoprotein and TGF-B1. Dual Role for Angiotensin Converting Enzyme - and Chymase-Angiotensin II Generation in Human Vascular Tissues. Insulin and Plasminogen Activator Inhibitor-1 in Atherogenesis: Evidence Relationshipin Dyslipidemia and Hypertension. Antiatherothrombotic Actions of Statins are Mediated by the Arterial Wall. Platelet Glycoproteins and Thrombosis: From Bedside to the Bench and Back to the Bedside. Alterations in Hemostatic Gene Expression in Obesity. Biological Functions and Proteins in Platelets with Inherited Large Platelets. Are there Differences Between Central and Peripheral Indices of Patients with Atrial Fibrillation. Clinical Medicine: Nivel targets and Therapies. Gene Therapy for Cardiovascular Diseases: An Overview. Therapeutic Angiogenesis and Nitric Oxide. A Novel Nutritional Therapy for Peripheral Arterial Disease. New Insights into the Cellular Basis of Coronary Artery Disease Mechanisms of Plaque Instability and Coronary Events: Potential Targets for Therapy. Vascular Protection: From basic Science to the Clinic Dysfunction. Intracellular Signaling in Vascular Cells. Apoptosis and Vascular Remodeling. Sex Hormones and Vascular Protection. Atherosclerosis. Thrombosis / Thrombolysis. Clinical Medicine: Novel Targets and Therapies.


    Gabor M. Rubanyi, Victor J. Dzau, John P. Cooke