1st Edition

Vascularization Regenerative Medicine and Tissue Engineering

Edited By Eric M. Brey Copyright 2015
    397 Pages 83 Color Illustrations
    by CRC Press

    397 Pages 83 Color Illustrations
    by CRC Press

    A Complex and Growing Field

    The study of vascularization in tissue engineering and regenerative medicine (TERM) and its applications is an emerging field that could revolutionize medical approaches for organ and tissue replacement, reconstruction, and regeneration.

    Designed specifically for researchers in TERM fields, Vascularization: Regenerative Medicine and Tissue Engineering provides a broad overview of vascularization in TERM applications. This text summarizes research in several areas, and includes contributions from leading experts in the field. It defines the difficulties associated with multicellular processes in vascularization and cell-source issues. It presents advanced biomaterial design strategies for control of vascular network formation and in silico models designed to provide insight not possible in experimental systems. It also examines imaging methods that are critical to understanding vascularization in engineered tissues, and addresses vascularization issues within the context of specific tissue applications.

    This text is divided into three parts; the first section focuses on the basics of vascularization. The second section provides general approaches for promoting vascularization. The final section presents tissue and organ-specific aspects of vascularization in regenerative medicine.

    Presents Areas of Substantial Clinical and Societal Impact

    The material contains research and science on the process of vessel assembly with an emphasis on methods for controlling the process for therapeutic applications. It describes the tissue and organ-specific aspects of vascularization in regenerative medicine, and refers to areas such as bone tissue engineering, vascularization of encapsulated cells, adipose tissue, bone and muscle engineering. It also provides a mechanistic understanding of the process and presentation of experimental and computational approaches that facilitate the study of vascular assembly, and includes enabling technologies such as nanotechnology, drug delivery, stem cells, microfluidics, and biomaterial design that are optimized for supporting the formation of extensive vascular networks in regenerative medicine.

    A guide for researchers developing new methods for modulating vessel assembly, this text can also be used by senior undergraduate and graduate students taking courses focused on TERM.

    Part 1 Cells

    Endothelial Progenitor Cells: Current Status

    Matthew R Richardson and Mervin C Yoder

    Role of Pericytes in Tissue Engineering

    Holly M Lauridsen and Anjelica L Gonzalez

    Mesenchymal Support Cells in the Assembly of Functional Vessel Networks

    Rahul K Singh, Marina Vigen, and Andrew J Putnam

    Adipose Stromal Vascular Fraction Cells for Vascularization of Engineered Tissues

    Stuart K Williams and James B Hoying

    Part 2 Biomaterials

    Vascular Development and Morphogenesis in Biomaterials

    Sebastian F Barreto-Ortiz, Quinton Smith, and Sharon Gerecht

    Biophysical Mechanisms That Govern the Vascularization of Microfluidic Scaffolds

    Keith H K Wong, James G Truslow, Aimal H Khankhel, and Joe Tien

    Engineered In Vitro Systems of the Microcirculation

    Monica L Moya, Christopher C W Hughes, and Steven C George

    Microfabrication of Three-Dimensional Vascular Structures

    Xin Zhao, Šeila Selimović, Gulden Camci-Unal, Mehmet R Dokmeci, Lara Yildirimer,

    Nasim Annabi, and Ali Khademhosseini

    Gradient Scaffolds for Vascularized Tissue Formation

    Michael V Turturro and Georgia Papavasiliou

    Part 3 Models

    Modeling Vascularization in Tissue Engineering Scaffolds

    Hamidreza Mehdizadeh, Eric Michael Brey, and Ali Cinar

    Multiscale Modeling of Angiogenesis

    David Noren, Rahul Rekhi, Byron Long, and Amina Ann Qutub

    Part 4 Imaging

    In Vivo Imaging Methods for the Assessment of Angiogenesis: Clinical and Experimental Applications

    Laura Nebuloni, Gisela A Kuhn, and Ralph Müller

    Part 5 Vascularized Tissues

    In Vivo Techniques and Strategies for Enhanced Vascularization of Engineered Bone

    Bao-Ngoc B Nguyen and John P Fisher

    Vascularization of Encapsulated Cells

    Shruti Balaji, John Patrick McQuilling, Omaditya Khanna, Eric Michael Brey,

    and Emmanuel C Opara

    Vascularization of Muscle

    Tracy Criswell, Zhan Wang, Yu Zhou, and Shay Soker

    Vascularization in Engineered Adipose Tissue

    Marcella K Vaicik, Ronald N Cohen, and Eric Michael Brey

    In Vivo Vascularization for Large-Volume Soft Tissue Engineering

    Geraldine M Mitchell and Wayne A Morrison



    Eric Michael Brey, PhD is a professor of biomedical engineering at the Illinois Institute of Technology and a research health scientist at the Hines Veterans Administration Hospital. He received BS and MEng degrees in chemical engineering from the University of Louisville, and a PhD in chemical engineering from Rice University. Dr. Brey’s research is focused on the areas of tissue engineering, vascularization, and biomaterials. Specifically, his group has developed and investigated new biomaterial and surgical approaches to control vessel assembly. His research has resulted in over 85 peer-reviewed publications, nine book chapters, and over 200 presentations and invited talks.