Vascularization : Regenerative Medicine and Tissue Engineering book cover
1st Edition

Regenerative Medicine and Tissue Engineering

Edited By

Eric M. Brey

ISBN 9781138076037
Published October 23, 2017 by CRC Press
397 Pages 83 Color Illustrations

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Book Description

A Complex and Growing Field

The study of vascularization in tissue engineering and regenerative medicine (TERM) and its applications is an emerging field that could revolutionize medical approaches for organ and tissue replacement, reconstruction, and regeneration.

Designed specifically for researchers in TERM fields, Vascularization: Regenerative Medicine and Tissue Engineering provides a broad overview of vascularization in TERM applications. This text summarizes research in several areas, and includes contributions from leading experts in the field. It defines the difficulties associated with multicellular processes in vascularization and cell-source issues. It presents advanced biomaterial design strategies for control of vascular network formation and in silico models designed to provide insight not possible in experimental systems. It also examines imaging methods that are critical to understanding vascularization in engineered tissues, and addresses vascularization issues within the context of specific tissue applications.

This text is divided into three parts; the first section focuses on the basics of vascularization. The second section provides general approaches for promoting vascularization. The final section presents tissue and organ-specific aspects of vascularization in regenerative medicine.

Presents Areas of Substantial Clinical and Societal Impact

The material contains research and science on the process of vessel assembly with an emphasis on methods for controlling the process for therapeutic applications. It describes the tissue and organ-specific aspects of vascularization in regenerative medicine, and refers to areas such as bone tissue engineering, vascularization of encapsulated cells, adipose tissue, bone and muscle engineering. It also provides a mechanistic understanding of the process and presentation of experimental and computational approaches that facilitate the study of vascular assembly, and includes enabling technologies such as nanotechnology, drug delivery, stem cells, microfluidics, and biomaterial design that are optimized for supporting the formation of extensive vascular networks in regenerative medicine.

A guide for researchers developing new methods for modulating vessel assembly, this text can also be used by senior undergraduate and graduate students taking courses focused on TERM.

Table of Contents

Part 1 Cells

Endothelial Progenitor Cells: Current Status

Matthew R Richardson and Mervin C Yoder

Role of Pericytes in Tissue Engineering

Holly M Lauridsen and Anjelica L Gonzalez

Mesenchymal Support Cells in the Assembly of Functional Vessel Networks

Rahul K Singh, Marina Vigen, and Andrew J Putnam

Adipose Stromal Vascular Fraction Cells for Vascularization of Engineered Tissues

Stuart K Williams and James B Hoying

Part 2 Biomaterials

Vascular Development and Morphogenesis in Biomaterials

Sebastian F Barreto-Ortiz, Quinton Smith, and Sharon Gerecht

Biophysical Mechanisms That Govern the Vascularization of Microfluidic Scaffolds

Keith H K Wong, James G Truslow, Aimal H Khankhel, and Joe Tien

Engineered In Vitro Systems of the Microcirculation

Monica L Moya, Christopher C W Hughes, and Steven C George

Microfabrication of Three-Dimensional Vascular Structures

Xin Zhao, Šeila Selimović, Gulden Camci-Unal, Mehmet R Dokmeci, Lara Yildirimer,

Nasim Annabi, and Ali Khademhosseini

Gradient Scaffolds for Vascularized Tissue Formation

Michael V Turturro and Georgia Papavasiliou

Part 3 Models

Modeling Vascularization in Tissue Engineering Scaffolds

Hamidreza Mehdizadeh, Eric Michael Brey, and Ali Cinar

Multiscale Modeling of Angiogenesis

David Noren, Rahul Rekhi, Byron Long, and Amina Ann Qutub

Part 4 Imaging

In Vivo Imaging Methods for the Assessment of Angiogenesis: Clinical and Experimental Applications

Laura Nebuloni, Gisela A Kuhn, and Ralph Müller

Part 5 Vascularized Tissues

In Vivo Techniques and Strategies for Enhanced Vascularization of Engineered Bone

Bao-Ngoc B Nguyen and John P Fisher

Vascularization of Encapsulated Cells

Shruti Balaji, John Patrick McQuilling, Omaditya Khanna, Eric Michael Brey,

and Emmanuel C Opara

Vascularization of Muscle

Tracy Criswell, Zhan Wang, Yu Zhou, and Shay Soker

Vascularization in Engineered Adipose Tissue

Marcella K Vaicik, Ronald N Cohen, and Eric Michael Brey

In Vivo Vascularization for Large-Volume Soft Tissue Engineering

Geraldine M Mitchell and Wayne A Morrison


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Eric Michael Brey, PhD is a professor of biomedical engineering at the Illinois Institute of Technology and a research health scientist at the Hines Veterans Administration Hospital. He received BS and MEng degrees in chemical engineering from the University of Louisville, and a PhD in chemical engineering from Rice University. Dr. Brey’s research is focused on the areas of tissue engineering, vascularization, and biomaterials. Specifically, his group has developed and investigated new biomaterial and surgical approaches to control vessel assembly. His research has resulted in over 85 peer-reviewed publications, nine book chapters, and over 200 presentations and invited talks.