397 pages | 83 Color Illus.
A Complex and Growing Field
The study of vascularization in tissue engineering and regenerative medicine (TERM) and its applications is an emerging field that could revolutionize medical approaches for organ and tissue replacement, reconstruction, and regeneration.
Designed specifically for researchers in TERM fields, Vascularization: Regenerative Medicine and Tissue Engineering provides a broad overview of vascularization in TERM applications. This text summarizes research in several areas, and includes contributions from leading experts in the field. It defines the difficulties associated with multicellular processes in vascularization and cell-source issues. It presents advanced biomaterial design strategies for control of vascular network formation and in silico models designed to provide insight not possible in experimental systems. It also examines imaging methods that are critical to understanding vascularization in engineered tissues, and addresses vascularization issues within the context of specific tissue applications.
This text is divided into three parts; the first section focuses on the basics of vascularization. The second section provides general approaches for promoting vascularization. The final section presents tissue and organ-specific aspects of vascularization in regenerative medicine.
Presents Areas of Substantial Clinical and Societal Impact
The material contains research and science on the process of vessel assembly with an emphasis on methods for controlling the process for therapeutic applications. It describes the tissue and organ-specific aspects of vascularization in regenerative medicine, and refers to areas such as bone tissue engineering, vascularization of encapsulated cells, adipose tissue, bone and muscle engineering. It also provides a mechanistic understanding of the process and presentation of experimental and computational approaches that facilitate the study of vascular assembly, and includes enabling technologies such as nanotechnology, drug delivery, stem cells, microfluidics, and biomaterial design that are optimized for supporting the formation of extensive vascular networks in regenerative medicine.
A guide for researchers developing new methods for modulating vessel assembly, this text can also be used by senior undergraduate and graduate students taking courses focused on TERM.
Part 1 Cells
Endothelial Progenitor Cells: Current Status
Matthew R Richardson and Mervin C Yoder
Role of Pericytes in Tissue Engineering
Holly M Lauridsen and Anjelica L Gonzalez
Mesenchymal Support Cells in the Assembly of Functional Vessel Networks
Rahul K Singh, Marina Vigen, and Andrew J Putnam
Adipose Stromal Vascular Fraction Cells for Vascularization of Engineered Tissues
Stuart K Williams and James B Hoying
Part 2 Biomaterials
Vascular Development and Morphogenesis in Biomaterials
Sebastian F Barreto-Ortiz, Quinton Smith, and Sharon Gerecht
Biophysical Mechanisms That Govern the Vascularization of Microfluidic Scaffolds
Keith H K Wong, James G Truslow, Aimal H Khankhel, and Joe Tien
Engineered In Vitro Systems of the Microcirculation
Monica L Moya, Christopher C W Hughes, and Steven C George
Microfabrication of Three-Dimensional Vascular Structures
Xin Zhao, Šeila Selimović, Gulden Camci-Unal, Mehmet R Dokmeci, Lara Yildirimer,
Nasim Annabi, and Ali Khademhosseini
Gradient Scaffolds for Vascularized Tissue Formation
Michael V Turturro and Georgia Papavasiliou
Part 3 Models
Modeling Vascularization in Tissue Engineering Scaffolds
Hamidreza Mehdizadeh, Eric Michael Brey, and Ali Cinar
Multiscale Modeling of Angiogenesis
David Noren, Rahul Rekhi, Byron Long, and Amina Ann Qutub
Part 4 Imaging
In Vivo Imaging Methods for the Assessment of Angiogenesis: Clinical and Experimental Applications
Laura Nebuloni, Gisela A Kuhn, and Ralph Müller
Part 5 Vascularized Tissues
In Vivo Techniques and Strategies for Enhanced Vascularization of Engineered Bone
Bao-Ngoc B Nguyen and John P Fisher
Vascularization of Encapsulated Cells
Shruti Balaji, John Patrick McQuilling, Omaditya Khanna, Eric Michael Brey,
and Emmanuel C Opara
Vascularization of Muscle
Tracy Criswell, Zhan Wang, Yu Zhou, and Shay Soker
Vascularization in Engineered Adipose Tissue
Marcella K Vaicik, Ronald N Cohen, and Eric Michael Brey
In Vivo Vascularization for Large-Volume Soft Tissue Engineering
Geraldine M Mitchell and Wayne A Morrison