Vibrational Spectroscopy for Tissue Analysis: 1st Edition (Hardback) book cover

Vibrational Spectroscopy for Tissue Analysis

1st Edition

By Ihtesham ur Rehman, Zanyar Movasaghi, Shazza Rehman

CRC Press

356 pages | 90 B/W Illus.

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Hardback: 9781439836088
pub: 2012-09-27
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Description

A rapidly growing field, vibrational spectroscopy has found applications in industries including pharmaceutical manufacture, food and drug safety, and process monitoring on production lines. In particular, interest in clinical spectroscopy is rising rapidly as researchers recognize the potential of the vibrational spectroscopic techniques—Infrared (IR) and Raman Spectroscopy—as noninvasive tissue diagnosis tools. However, the details of the characteristic peak frequencies and their relationship to specific functional groups present in the biological tissues have not been fully understood.

Vibrational Spectroscopy for Tissue Analysis introduces IR and Raman Spectroscopy to those scientists who are either using these spectroscopic techniques to address clinical problems or planning to use spectroscopy to analyze clinical tissues and understand their chemical composition. By compiling the interpretations and understandings of the spectral peaks of the biological molecules in one place, this book aids in the understanding of IR and Raman Spectroscopy, and what these techniques can offer both in early diagnosis of the disease and monitoring of the progression of the disease.

Despite the tremendous advances in the field of spectroscopy, where new applications are emerging at the pace of development, there are still areas of research that are crying for further exploration. This book bridges the gap between the spectroscopic research and medical applications.

Table of Contents

Introduction to Spectroscopy

History

Regions of the Spectrum

FTIR and Dipole Moment Change

FTIR and Raman Spectrometry

References

Spectroscopy and Molecular Changes in Cancer Cells

Introduction

Understanding Cancer

Peak Assignments of Biological Molecules

References

The Biology of Cancer

Epidemiology of Cancer

Cancer Development

Causes of Cancer

Mechanisms in Generation of Tumors

Oncogenes

Tumour Suppressor Genes

Possible Functions of Tumour Suppressor Genes

The Cell Cycle

Phases of the Cell Cycle

Regulation of the Cell Cycle

Properties of Cancerous Cells

Disordered Mechanisms in Malignant Cells

References

Vibrational Spectroscopy and Cancer

Introduction

Skin Cancer

Head and Neck Cancer

Other Biological Molecules

Breast Cancer

Cervical and Ovarian Cancers

Adenocarcinoma

Epithelial Cancer

Lung Cancer

Breast Cancer

Skin Cancer

Gastrointestinal Cancer

Colon Cancer

Oesophageal Cancer

Stomach Cancer

Pancreatic Cancer

Gastric Cancer

Brain Tissues

Oral Squamous Cell Carcinoma

Nasopharyngeal Carcinoma

Blood-Related Tissue and Organs

FTIR Spectroscopy for Cancer Grading

Prostate Cancer

Colon Cancer

Investigating Cell Lines

Analysing Saliva

Other Spectroscopic Studies

Summary

References

FTIR and Raman Spectroscopy and Imaging of Breast Cancer

Introduction

Materials and Methods

Analysis of Cancerous Tissues Using FTIR Rapid Scan Imaging

Summary

Future Work

References

Detecting and Monitoring of Cancer at the Cellular Level

Introduction

Analysis of Resistant and Sensitive Subtypes of Testicular Cancer Cell Lines Quantitative Analysis of the Spectra of 833k Samples

Treated Cell Lines

Other Testicular Cell Lines

Summary

Acknowledgements

References

Chemical Structural Analysis of Bone by Spectroscopy

Introduction

Raman Spectroscopy of Bone

Comparison of Natural and Synthetic Apatites

Infrared Spectroscopy of Bone

FTIR Spectral Data Acquisition and Analysis

Summary

References

FTIR and Raman Characteristic Peak Frequencies in Biological Studies

Introduction

Characteristic Peak Frequencies

Summary

References

Future Potential Clinical Applications of Spectroscopic Techniques in Human Diseases

Diagnosis

Determination of Prognostic Factors

Determination of Extent of Disease Process

Designing Therapy and Guiding Tissue Biopsy

Evaluating Efficacy and Response to Treatment

Earlier Detection of Recurrence and Metastases

Detection of Tissue Injury

Detection of Therapeutic Drug Levels

References

About the Authors

Ihtesham Ur Rehman is a reader in biomedical materials at Queen Mary, University of London, UK.

Zanyar Movasaghi is a doctor of dental surgery at Queen Mary, University of London, UK.

Shazza Rehman is a consultant in medical oncology with St. George’s Healthcare NHS Trust.

About the Series

Series in Medical Physics and Biomedical Engineering

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
SCI055000
SCIENCE / Physics
SCI078000
SCIENCE / Spectroscopy & Spectrum Analysis
TEC059000
TECHNOLOGY & ENGINEERING / Biomedical