Vitamin C: New Biochemical and Functional Insights, 1st Edition (Hardback) book cover

Vitamin C

New Biochemical and Functional Insights, 1st Edition

Edited by Qi Chen, Margreet C M Vissers

CRC Press

256 pages | 29 Color Illus. | 10 B/W Illus.

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Hardback: 9781138337992
pub: 2020-02-06
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Vitamin C holds a unique place in scientific and cultural history. In this book, a group of leading scientific research explore the myriad ways Vitamin C is employed during normal physiological function. This book also provides updates on recent uses ofVitamin C in cancer treatment through high dose intravenous therapies, the ways Vitamin C reduces or prevents sepsis and in the treatment of infectious disease, and the ways Vitamin C improves succesful stem cell transplantation, as well as other health implications.

Key selling features:

  • Reviews the history and recent research on the benefits and uses of Vitamin C
  • Focuses special attention on the ways Vitamin C can be used in the treatment of cancers
  • Discusses how Vitamin C is employed against infectious disease
  • Includes chapters from a team of leading international scholars

Table of Contents

Introduction: on intensive physiology study leads to implications in diseases. Part I Chemistry and physiology of vitamin C. Discovery of vitamin C: the history. Basics of vitamin C: chemistry, and redox biochemistry. Vitamin C physiology: transporters and metabolism. Vitamin C biological functions as co-factors for enzymes, such as in biosynthesis of collagen, carnitine, neurotransmitters, and others. Part II vitamin C and cancer. History in cancer treatment: Linus Pauling’s theory and the conflict with Mayo Clinic trials. High dose intravenous ascorbate (IVC): prooxidant actions. IVC as multi-target anti-cancer agent. IVC and epigenetics. IVC in hypoxia. Overview of recent clinical trials. IVC with radiation therapy. IVC and QOL in cancer patients. with other naturopathy for cancer. Part III Vitamin C and infectious diseases. Vitamin C in sepsis. Vitamin C in other infections. Part IV Vitamin C and stem cells. Vitamin C and bone marrow transplantation. Vitamin C and Tet (s). Vitamin C and somatic cell reprogramming. Part V Vitamin C in other health implications. Vitamin C in the brain/neurotransmitters. Vitamin C in diabetes.

About the Editors

Qi Chen, PhD, associate professor at the University of Kansas Medical Center, has more than 10 years of research experiences in vitamin C. She had worked with Mark Levine whose in situ pharmacokinetics studies on vitamin C have laid the foundation for the dietary recommendations used in many countries. She is also a major player in the discovery of the pro-oxidant role of vitamin C at supra-nutritional concentrations. Her publications have been reported by major health media several times. Her current research work is at the fore front in using high dose intravenous vitamin C in cancer treatment.

Margareet C. M. Vissers is Research Professor at the Centre for Free Radical Research in the Pathology Department of the University of Otago in Christchurch, New Zealand. She is also the Associate Dean of Research at the University of Otago. Her research is devoted to the role of reactive oxidants in biological systems, the consequences of their formation and the effects they initiate in cell signaling, as well as the protection offered by antioxidants. She is also interested in the ways in which neutrophils cause injury to cells and tissues in the process of acute inflammation and infection, and the contribution of neutrophil-derived oxidants and proteinases to the resulting pathology. A focus of this research has been the toxicity of hypochlorous acid (HOCl) and hypobromous acid (HOBr), major oxidants produced by neutrophils, and the effects of chloramines and bromamines which are derived from them. She has shown that these oxidants initiate cell stress signaling responses and death pathways including apoptosis. Vissers is the author or coauthor of more than 100 peer reviewed journal articles, book chapters and coference proceedings.

About the Series

Oxidative Stress and Disease

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacology
SCIENCE / Life Sciences / Biology / Molecular Biology
SCIENCE / Life Sciences / General