1st Edition

Vitamin K in Health and Disease

By John W. Suttie Copyright 2009
    236 Pages 50 B/W Illustrations
    by CRC Press

    236 Pages 50 B/W Illustrations
    by CRC Press

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    Vitamin K: Past, Present, Future

    Essential for normal blood coagulation, possible roles in bone, vascular, and tumor metabolism, and a nutrient critical to the health of the newborn infant -- these are just some of the many health-promoting aspects of Vitamin K. Vitamin K in Health and Disease navigates the exciting research venues that have opened in the past few years surrounding this micro nutrient, particularly its role in skeletal and cardiovascular health. It also provides the historical timeline of vitamin K research and discovery that began in the 1930s.

    Comprehensive in scope, this book offers complete coverage of the chemistry of Vitamin K; deficiency signs and nutritional assessment; metabolism and biochemistry; and pharmacology. It also presents up-to-date scientific studies on the nutritional, metabolic, and medical aspects along with a review of current dietary requirements and the difficulty involved in establishing an appropriate dietary reference intake for Vitamin K.

    Extensive References, More than 45 Illustrations, Numerous Tables

    Based on John Suttie’s 35 years of experience directing a broad vitamin K research program, this work discusses plasma and non-plasma Vitamin K-dependent proteins. It also includes helpful tables on food sources, population intake of Vitamin K, and the impact of diet on the circulating levels of the vitamin – highlighting the role of vitamin K in health and disease. Vitamin K in Health and Disease provides a foundation for future innovations in research and in determining the best ways to implement current knowledge.

    Chapter 1: Historical Background

    Chapter 2: Active Forms, Antagonists, Physical Properties, and Synthesis of Vitamin K

    Chapter 3: Dietary Intake of Vitamin K and the Vitamin K Content of Foods and Plasma

    Chapter 4: Vitamin K-Dependent Carboxylase and Vitamin K Epoxide Reductase

    Chapter 5: Vitamin K-Dependent Proteins

    Chapter 6: Absorption, Storage, and Metabolism of Vitamin K

    Chapter 7: Public Health Concerns Related to Vitamin K Status

    Chapter 8: Vitamin K Requirements, Toxicity, and Other Metabolic Interactions


    Dr. John W. Suttie, Ph.D., is the Katherine Berns Van Donk Steenbock Professor Emeritus in the Department of Biochemistry and former Chair of the Department of Nutritional Sciences at the University of Wisconsin-Madison. He has broad expertise in biochemistry and human nutrition. Dr. Suttie received his B.S., M.S., and Ph.D. degrees from the University of Wisconsin-Madison. He has been involved in the activities of the Food and Nutrition Board of the Institute of Medicine to establish dietary requirements and is a member of the National Academy of Sciences.