Chapter 1 Introduction
Rong (Ron) Liu
Chapter 2 Solubility Theory
Steven H. Neau
Chapter 3 Prediction of Solubility
Yisheng Chen, Xiaohong Qi, and Rong (Ron) Liu
Chapter 4 Preformulation Aspects of Insoluble Compounds
Wei-Qin (Tony) Tong and Hong Wen
Chapter 5 Water-Insoluble Drugs and Their Pharmacokinetic Behaviors
Honghui Zhou and Hao Zhu
Chapter 6 Regulatory Aspects of Dissolution for Low Solubility Drug Products
Pradeep Sathe, Robert A. Lionberger, Sau Lawrence Lee, Lawrence X. Yu, and Di (Doris) Zhang
Chapter 7 Formulation Strategies and Practice Used for Drug Candidates with Water-Insoluble Properties for Toxicology, Biology, and Pharmacology Studies in Discovery Support
Lian-Feng Huang, Jinquan Dong, and Shyam B. Karki
Chapter 8 Application of Complexation in Drug Development for Insoluble Compounds
Wei-Qin (Tony) Tong and Hong Wen
Chapter 9 Solubilization Using Cosolvent Approach
Jay S. Trivedi and Zhanguo Yue
Chapter 10 Emulsions, Microemulsions, and Lipid-Based Drug Delivery Systems for Drug Solubilization and Delivery·Part I: Parenteral Applications
John B. Cannon, Yi Shi, and Pramod Gupta
Chapter 11 Emulsions, Microemulsions, and Lipid-Based Drug Delivery Systems for Drug Solubilization and Delivery·Part II: Oral Applications
John B. Cannon and Michelle A. Long
Chapter 12 Micellization and Drug Solubility Enhancement
Rong (Ron) Liu, Rose-Marie Dannenfelser, Shoufeng Li, and Zhanguo Yue
Chapter 13 Polymeric Micelles in Water-Insoluble Drug Delivery
Rong (Ron) Liu, M. Laird Forrest, Glen S. Kwon, Xiaobing Xiong, and Zhihong (John) Zhang
Chapter 14 Liposomes in Solubilization
Rong (Ron) Liu, John B. Cannon, and Sophia Y.L. Paspal
Chapter 15 Pharmaceutical Salts
Steven H. Neau and Nikhil C. Loka
Chapter 16 Prodrugs for Improved Solubility in Water
Steven H. Neau, Nikhil C. Loka, and Kalyan K. Saripella
Chapter 17 Particle Size Reduction
Xiang (Lisa) Li, Zhanguo Yue, Robert W. Lee, James McShane, J. Michael Shaw, Ray W. Wood, and Dinesh B. Shenoy
Chapter 18 Development of Solid Dispersion for Poorly Water-Soluble Drugs
Madhav Vasanthavada, Simerdeep Singh Gupta, Wei-Qin (Tony) Tong, and Abu T.M. Serajuddin
Chapter 19 Alteration of the Solid State of the Drug Substances: Polymorphs, Solvates, and Amorphous Forms
Paul B. Myrdal, Stephen J. Franklin, and Michael J. Jozwiakowski
Chapter 20 Pharmaceutical Powder Technology·ICH Q8 and Building the Pyramid of Knowledge
Hans Leuenberger, Silvia Kocova El-Arini, and Gabriele Betz
Chapter 21 Soft Gelatin Capsules Development
S. Esmail Tabibi, Liangran Guo, and Shanker L. Gupta
Chapter 22 Oral Modified-Release Drug Delivery for Water-Insoluble Drugs
Shaoling Li, Nuo (Nolan) Wang, Rong (Ron) Liu, Zhanguo Yue, and Zhihong (John) Zhang
Chapter 23 Scalable Manufacturing of Water-Insoluble Drug Products
Nitin P. Pathak, Richard (Ruey-ching) Hwang, and Xiaohong Qi
Index
Biography
Ron Liu is CEO of AustarPharma, a pharmaceutical company based in Edison, New Jersey.
