Water: The Forgotten Biological Molecule, 1st Edition (Hardback) book cover


The Forgotten Biological Molecule, 1st Edition

Edited by Denis Le Bihan, Hidenao Fukuyama

Jenny Stanford Publishing

399 pages | 62 Color Illus. | 62 B/W Illus.

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Hardback: 9789814267526
pub: 2010-11-30
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The main objective of this book is to bring together multidisciplinary contributions from leading authorities on the properties and roles of water in cell systems which are otherwise dispersed in the literature and difficult to gather. The authors are drawn from areas of physics, chemistry, biology and physiology, where water plays a central role. The book focuses on current research and developments in the theoretical and experimental studies of water in biological systems and compounds, such as interaction with hydrophobic or hydrophilic structures, protein and membrane surfaces. It provides insights into the importance of water in cellular processes and physiology and, ultimately, in life, brain function, and health.


"This book offers refreshing new insights into a fundamental problem in biology at the beginning of the 21st century: ‘How does the intricate dance between macromolecules and water molecules control fundamentally important biological processes?’ Lacking basic theoretical understanding at the molecular level, we resort to empirical relationships with limited ability to predict future outcomes in biology, biotechnology, and medicine. The volume pushes the frontier using experimental insights gained from the most recent advances in technology to narrow the search."

- Dr. Gary Fullerton, University of Colorado Denver, USA

"This book courageously confronts the heart of natural science through water, clarifying this mysterious and attractive molecule’s role in life through a trans-disciplinary approach. It will no doubt be the first light of dawn for a new physiology and brain science."

- Dr. Hideaki Koizumi, Fellow, Hitachi, Ltd., Japan

Table of Contents


The Water Molecule, Liquid Water, Hydrogen Bonds, and Water Networks

Martin Chaplin


Protein Dynamics and Hydration Water

Marie-Claire Bellissent-Funel

Effect of Hydration on Protein Dynamics

Mikio Kataoka and Hiroshi Nakagawa

Statistical-Mechanics Theory of Molecular Recognition: Water and Other Molecules Recognized by Protein

Norio Yoshida, Yasuomi Kiyota, Thanyada Rungrotmongkol, Saree Phongphanphanee, Takashi Imai, and Fumio Hirata

Hydrophobic Molecules in Water

B. Cabane


How Water Meets a Hydrophobic Interface

Yingxi (Elaine) Zhu

Characteristics of Water Adjacent to Hydrophilic Interfaces

Hyok Yoo, David R. Baker, Christopher M. Pirie, Basil Hovakeemian, and Gerald H. Pollack


Water and Membranes: Insights from Molecular Dynamics Simulations

Mounir Tarek

Water in Membranes, Water in Cells: Neutrons Reveal Dynamics and Interactions

M. Jasnin, A. M. Stadler, and G. Zaccai

Structure and Inhibitor of Water Channel in Brain

Yukihiro Tanimura, Kazutoshi Tani, Hiroshi Suzuki, Kouki Nishikawa, Akiko Kamegawa, Yoko Hiroaki, and Yoshinori Fujiyoshi

Water, Membranes, and Life Without Water

John H. Crowe


Interfacial Water and Cell Architecture/Function

Frank Mayer

Water-Based Biological Homeostasis in Multiple Fluid-Filled Compartments in the Higher Organisms: Regulation by the Paracellular Barrier–Forming Tight Junctions of Epithelial Cell Sheets

Yuji Yamazaki, Atsushi Tamura, and Sachiko Tsukita

Role of the Septin Cytoskeleton for the Functional Organization of the Plasma Membrane

Makoto Kinoshita

Water Movements Associated with Neuronal Activity Revealed by Optical Methods: Focus on Digital Holographic Microscopy

P. Marquet, P. Jourdain, C. Depeursinge, and P. J. Magistretti


Water and the Mind: Role of Water, Cell Membranes, and Diffusion in Brain Function Imaging

Denis Le Bihan

Water and Brain

Hidenao Fukuyama

Water, a Key Molecule for Living, Water in Metabolism and Biodiversity

Gilles Boeuf

About the Editors

Denis Le Bihan is a member of the French Academy of Sciences and director and founder of NeuroSpin, an ultra-high-field MRI facility (Atomic Energy Commission, Saclay, France).

Hidenao Fukuyama is chairman of the Human Brain Research Center, Kyoto University Graduate School of Medicine, Japan.

Subject Categories

BISAC Subject Codes/Headings:
SCIENCE / Life Sciences / Biology / Molecular Biology
SCIENCE / Life Sciences / General
TECHNOLOGY & ENGINEERING / Environmental / Water Supply