1st Edition

X-ray Contrast Agent Technology A Revolutionary History

By Christoph de Haen Copyright 2019
    338 Pages
    by CRC Press

    338 Pages 2 Color & 47 B/W Illustrations
    by CRC Press

    338 Pages 2 Color & 47 B/W Illustrations
    by CRC Press

    This book documents the fascinating history of radiological techniques that use contrast agents. The text includes many of the fundamental documentary sources that bring to life the social and scientific background of the discoveries, the personalities of the discoverers, and implementation of new technologies. Such agents when used with X-rays allow clinicians to distinguish anatomical structures with nearly identical densities. Focus is on urological and angiographic uses of contrast agents.


    Key selling features:

    • Documents and thoroughly references the history of contrast agent development

    • Reviews the priority and importance of patents

    • Discusses the role that important individual scientists and leading research institutions have played in technology development and implementation

    Chapter 1 Introduction, Chapter 2 Methodological Considerations, Historical and Sociological Perspectives, Technological Innovation, The Analytical Model of Technology Genesis and Shaping, Chapter 3 Assembly of a Technological Vision for X-Ray Contrast Agents, Chapter 4 Uro-Angiographic Contrast Agents—The Holy Grail, Technology Genesis Phase, History, From Sodium Iodide to Uro-selectan Sodium and Methiodal Sodium, Contrasting Historical Interpretations, The Dynamics of Technology Genesis, The Failure of One-Dimensional Reductionism, Technical Knowledge from Interference of Different Knowledge Cultures, Interference as Communication and Individuation of Knowledge.


    Christoph de Haën, born September 9, 1940 in Switzerland, studied chemistry and

    biology in Lausanne, Zurich, and Rome, earning a master’s degree in chemistry

    from the Swiss Federal Institute of Technology (ETH Zurich), followed by a PhD

    in molecular biology at the same institution. After a postdoctoral fellowship in biochemistry

    at the University of Washington, Seattle, he became research faculty at

    the same institution, jointly appointed in the Departments of Medicine (Division of

    Endocrinology and Metabolism) and Biochemistry. There he moved up the ranks to

    Research Full Professor and Graduate Faculty. In mid-career he joined the Bracco

    company, a worldwide active pharmaceutical corporation, headquartered in Milan,

    Italy. There he held various leadership positions in global research and development,

    including Head of the Milano Research Center and Scientific Advisor to the Bracco

    Group of Companies. The principle field of activity was contrast agents for various

    diagnostic imaging modalities. His publications span a wide variety of fields, including

    social science ones. He retired in 2005 and lives in Switzerland.

    "This book, written by the eminent chemist and former scientific adviser to Bracco, covers the history of x-ray contrast agents concentrating primarily on uroangiographic agents. The contributions of the giants in this field, such as Lichtenberg, Swick and of course Almen, are covered in considerable depth." - Dr. Arpan K Banerjee, past chair and trustee, British Society for the History of Radiology