The increasing demand for innovative techniques arises from the lack of safe, effective, and patient-friendly therapies for neurodegenerative disorders. With this objective in mind, the chapters of the book are structured to offer a thorough insight into recent advancements in utilizing the Zebrafish (ZF) as a model for studying Parkinson's disease (PD). This book aims to present readers with a comprehensive understanding of the clinical application of the ZF model in treating PD, encompassing the latest developments, challenges, safety considerations, toxicity issues, regulatory aspects, future potential, and limitations. Individuals in academia, the scientific community, business, and education seeking a more effective approach to target the brain stand to benefit from this resource.
Key Features
· Provides a comparative perspective of the Zebrafish-Parkinson’s Disease model
· Highlights the restrictions of available medicines
· Describes biochemical and histopathological characteristics, advantages and disadvantages of this model
· Emphasizes distinct facets of histopathology
· Presents advances and developments of the future potential perspectives
SECTION-I: FROM AQUARIUM TO LAB: THE RISE OF ZEBRAFISH AS A MODEL ORGANISM
Ch1 General Methods For Zebrafish Care
Fatemeh Delkhosh Kasmaie, Yaser Tahamtani, Mohammad Rezaei
Ch2 Breeding of Zebrafish and its life cycle
Hakim Mudasir Maqsood1, Inain Jaias, Asra Imtiyaz Mattoo, Towseef Akram, Wasim Akram5, Nazir Ahmad Ganai
Ch3 Neurobehavioral assessment of Zebrafish
Shaimaa Nasr Amin, Dalia Azmy Elberry
Ch4 Cellular and Genetic Methods in Zebrafish
Dalia Hamza, Elshaimaa Ismael, Hala Zaher
Ch5 Repeated blood sampling from an adult Danio rerio
Manar A. Eissa, Raihan Abdullah, Faez Sharif, Mohd Hamzah Mohd Nasir
Ch6 Zebrafish Culture
Zahra Morshed1, Fatemeh Delkhosh Kasmaie, Mahsa Valizade, Mohammad Rezaei, Yaser Tahamtani
Ch7 Calcium Imaging of Neuronal Activity in Free-Swimming
Larval Zebrafish
Rui Peng, Xiuyun Liu, Meijun Pang
Ch8 Anesthesia, Analgesia, and Euthanasia of the Laboratory Zebrafish
Azhwar Raghunath
Ch9 Zebrafish Guidelines, Policies and Regulations in Research
Yashwanth Bomma, Rajesh Pamanji, Joseph Selvin
SECTION-II: ZEBRAFISH AS A MODEL OF PARKINSON’S DISEASE
Ch10 The Role of Neurotransmitters in the Pathophysiology of Parkinson's Disease
Shaimaa Nasr Amin , Dalia Azmy Elberry
Ch11 Diagnosis and Biomarkers of PD
Abraham Olufemi Asuku, Maryam Tayo Ayinla, Olajide Tobiloba Samuel, Ebele Joan Ajagun, Kaosara Oyinola Ganiyu, Yusuf Olamilekan Hamza, Ayodeji Johnson Ajibare, Taoheed Adedeji Abdulsalam
Ch12 Parkinson's Disease Models Pros and Cons
Sobhana M, Rajesh Pamanji, Joseph Selvin
Ch13 Pharmacotherapy of PD and their limitations
Ebele Joan Ajagun, Abraham Olufemi Asuku1,Maryam Tayo Ayinla, Taoheed Adedeji Abdulsalam, Ayodeji Johnson Ajibare, Olajide Tobiloba Samuel, Yusuf Olamilekan Hamza, Kaosara Oyinola Ganiyu
Ch14 Induction and VALIDATION OF ZF model of PD
Gisha Sivan, Rajesh Pamanji, Joseph Selvin
Ch15 Zebra fish as a model for a novel Parkinson’s disease protective natural Product
Hagar F. Forsan
Ch16 Zebrafish model for studying microbiome associated Parkinson’s Disease
Vishnu Prasad Nair R U, Rajesh Pamanji, Joseph Selvin
Ch17 Transgenic zebrafish reporter lines for in vivo studying of Parkinson’s disease
Nicola Facchinello
Ch18 Interplay of neurodenegrative disorders in zebrafish: unlocking the mystery
Sanobar Shariff , Burhan Kantawala, Qamar Sultana, Hasiba Karimi, Ider Oujamaa, Vivek Sanker
Ch19 Smart Capsule and Edible Bird's Nest: Charting New Frontiers in Parkinson’s Disease Defense-An Experimental Protocol Perspective
Wael MY Mohamed
Ch20 Zebrafish Model for Drug Discovery and Screening
Sarah Hassan, Jabra Mustafa, Ahmad Hassan, Wael Mohamed
Biography
Wael Mohamed Yousef Mohamed
BBCH (Egypt), MMSc (Egypt), MD/PhD (USA)
Dr. Mohamed, a Physician Neuroscientist, earned his PhD from PSU in the USA and currently holds the position of Associate Professor at IIUM Medical School in Malaysia. With an extensive background, Dr. Mohamed has been invited to deliver over 150 lectures both domestically and internationally. His contributions to Neuroscience/Psychiatry are notable, with the publication of more than 100 peer-reviewed papers, boasting an h-index of 20. Furthermore, Dr. Mohamed serves as an editor for Frontiers in Neurology and PLOS-ONE Journals, where he has contributed to various journal special issues on brain disorders. In the realm of book editing, he is actively involved with Springer, CRC, and Cambridge in the field of neuroscience. His research endeavors have attracted numerous grants from esteemed national and international organizations, including IBRO, ISN, MJF, STDF, FRGS, and INDO-ASEAN, amounting to a total research funding of half a million US$. Notably, he is the founder and chair of the AfrAbia-PD-Genomic Consortium.
