Shui Qing Ye

Biography

Shui Qing Ye, M.D., Ph.D., is the William R. Brown/Missouri Endowed Chair in Medical Genetics and Molecular Medicine and a tenured Full Professor in Department of Biomedical & Health Informatics and Department of Pediatrics at University of Missouri at Kansas City School of Medicine, Missouri, USA. He is also the Director in the Division of Experimental and Translational Genetics, Department of Pediatrics and Director in the Core of Omic Research at The Children’s Mercy Hospital. Dr. Ye completed his medical education from Wuhan University School of Medicine, Wuhan, China and earned his Ph.D. from the University of Chicago Pritzker School of Medicine, Chicago, USA. Dr. Ye’s academic career trajectory has evolved from an Assistant Professor in Johns Hopkins University followed by an Associate Professorship in University of Chicago to a tenured Full Professor in University of Missouri at Columbia before taking up current positions.
Dr. Ye has been engaged in biomedical researches for more than 30 years with experience as principal investigators in NIH funded R01 or Pharmaceutical company sponsored research projects as well as co-investigators in NIH-funded RO1, SCCOR, PPG, and private foundation fundings. He has served in grant review panels or study sections of NHLBI/NIH, Department of Defense, and American Heart Association. He is a current member in American Association for the Advancement of Science, American Heart Association and American Thoracic Society. Dr. Ye has had more than 170 publications of peer-reviewed research articles, abstracts, reviews, book chapters and he has participated in the peer-review activity for a number of scientific journals.  
Dr. Ye is keen at applying high-throughput genomic and transcriptomic approaches or “Big Data” into his biomedical researches. Via a direct DNA sequencing to identify single nucleotide polymorphisms in patient DNA samples, his lab first reported a “Susceptible haplotype” and a “Protective haplotype” in the human pre-B-cell colony enhancing factor gene promoter to be associated with acute respiratory distress syndrome. By a DNA microarray to detect differentially expressed genes, Dr. Ye’s lab first discovered that pre-B-cell colony enhancing factor gene was highly upregulated as a biomarker in acute respiratory distress syndrome. Dr. Ye had taken a helm as the Director, Gene Expression Profiling Core in Center of Translational Respiratory Medicine in Johns Hopkins University School of Medicine and the Director, Molecular Resource Core in a NIH funded Program Project Grant on Lung Endothelial Pathobiology in University of Chicago Pritzker School of Medicine. He is currently directing the Core of Omic Research at The Children’s Mercy Hospital, University of Missouri at Kansas City, which has conducted exome-seq, RNA-seq, miRNA-seq, and microbiome-seq using the state of the art next generation DNA sequencing technologies. The Core is continuously expanding its scope of service on omic research. Dr. Ye has published a book as the editor on “Bioinformatics: A Practical Approach” by CRC PRESS / Taylor & Francis Group, New York, USA. His newly edited book entitled “Big Data Analysis for Bioinformatics and Biomedical Discoveries” is in press by CRC PRESS / Taylor & Francis Group, New York, USA. One of Dr. Ye’s current and growing research interests is to apply Translational Bioinformatics to leverage “Big Data” to make new biological discoveries and gain new unifying global biological insights, which may lead to the development of new diagnostic and therapeutic targets for human diseases.

Education

MB/MS (MD equivalent), Wuhan University, China, 1982
PhD, Universty of Chicago, USA, 1993

Areas of Research / Professional Expertise

■My current and growing research interests cover three major areas: 1. To investigate Nicotinamide Phosphoribosyltransferase (NAMPT, also called pre-B-cell colony enhancing factor or visfatin) in the human physiology and pathology such as role of NAMPT in embryonic and organ development, acute respiratory distress syndrome, cancer, drug induced liver toxicity, stroke; 2. To dissect genetic components of complex human diseases such as coronary artery, chronic kidney disease, arthritis using omics technologies; 3. To apply Translational Bioinformatics to leverage omics data to make new biological discoveries and gain new unifying global biological insights, which may lead to the development of new diagnostic and therapeutic targets for human diseases.
■Knowledge of most, if not all, facets of biomedical researches such as grant proposal, experimental design and execution, data collection and analyses, manuscript writings and publications, oral or poster presentations of research findings in national and international conferences
■Skills in various laboratory techniques vetted in Biochemistry, Cell Biology, Genetics and Genomics, Molecular Biology, Animal Models of Human Diseases, the use of computers in both Windows- or Linux-based operating environments and translational bioinformatic rendering, and the application of next generation DNA sequencing for medical discoveries
■Abilities to design and execute translational research experiments, to lead or coordinate federally-, locally- or institutionally-sponsored research projects, to develop and implement short- and long-range research goals

Personal Interests

Play table-tennis as a pastime
Enjoy reading & moviegoing
Love travel & sightseeing

Books