Martin Patrick Holt Author of Evaluating Organization Development
FEATURED AUTHOR

Martin Patrick Holt

Mr
Halcyon

Up to 2000, over a period of 17 years, I was permanently employed, full time, working in quality management (QA, QC, validation, new products). I was instrumental in taking 2 companies through FDA inspections. I graduated and gained an Advanced Medical Statistics and Information Technology MSc in September 2000 (distinction in the 3 month dissertation) and have worked freelance from July 2005 making use of this relatively rare skill-set: Freelance Medical Statistician and Quality Expert. My max

Subjects: Statistics

Biography

PROFILE

I am a hard working person with many transferable skills. I can communicate on many levels, from student to Professor, as I believe if you can’t explain it simply, you don’t understand it. I am now looking for a new challenge where I can use my previous experience to the full.

EMPLOYMENT HISTORY
March 2016 – Present
I am currently offering a private tutoring service for math’s A ‘level and above.
January 2014- Present
I am currently collaborating in the writing of an encyclopedia for Medical Statistics, in between working on projects on which my help has been sought. This is due to be published in December 2016

July 2010- Present
I started a period of working from home as a Freelance Medical Statistician and being a house husband, supporting my two sons and my wife.

September 2006- April 2009
I worked as a consulting Medical Statistician for Professor A.H Gershlick and with Professor K.R Adams on the Scope Project “scoring for Percutaneous Coronary Intervention Events”. At times I worked with three doctors as well as Professors Gershlick and Abrams, and this led to the publication of three abstracts and one poster (see below), but the main project was paused in April 2009 at the analytic stage (I handed it over to the department’s statistician in July 2010)

October 2001- 2015
I began working with Margaret Hidderley, a Macmillan Nurse Specialist employed by Southern Derbyshire Acute Hospitals NHS Trust on the effects of Autogenic Training (AT): http://www.autogenic-therapy.org.uk/) on the outcomes for ladies with early stage breast cancer. AT is often referred to as “westernised medication” a form of self-hypnosis. The pilot study strongly supports the need for a full-scale study and we have been actively pursuing funding to do this.

March 2005-Present
In March 2005 I founded the mailing list “MedStats” (http://groups.google.com/group/MedStats). This list promotes open discussions on statistical issues raised by anyone who chooses to join. It is open to view by anyone on the internet but to post a question or to contribute to the discussion one must join. I am active in contributing to the discussions.

July 2008- 2015
In July 2008 I replied to an advertisement from J. Golson Media (USA) looking for authors to write sections of “The Encyclopedia of Mathematics and Society”. I successfully submitted a number of articles. I have recently taken this up again. I am also currently co-authoring a 1000 page long Encyclopedia in Medical Statistics.




July 2005-July 2006
I have also worked as a Medical Writer for Framingham BC, writing abstracts for papers. Framingham collated and published these abstracts and then sent them on to clinicians who welcomed them.

July 2006-December 2006
I tutored an undergraduate Psychologist in Medical Statistics.

July 2006- December 2006
In December 2006 I completed a NCFE course in Access Auditing for Disabled People (NQF Level Equivalence 3). I then, in my spare time, worked with the Leicestershire Centre for Integrated Living (LCIL) to visit buildings as requested to check for suitable access arrangements. I am a Trustee on the Board for LCIL.

July 2002- July 2003
Over this time I worked at the Birmingham Clinical Trials Unit (BCTU) as the chief statistician for the National Acute Myeloid Leukemia Clinical Trial 15.

September 2000-June 2002
From September 2000 until I moved to BCTU I was the Medical Statistician at the Southern Derbyshire Acute Hospitals Trust, helping researchers at the two hospitals: Derby City and the Royal.

September 1999-October 2000
I gained a distinction in the summer project of an Advanced MSc in “Medical Statistics and Information Technology” at Leicester/De Montfort Universities in October 2000. I also won the Diane Jackson Memorial Prize for services rendered in support of the Health Service.

1996
In 1996 I took the Open University M101 Math’s Foundation Course, scoring 88%.

July 1983- July 1999
Before adopting a career in Medical Statistics I worked as the Quality Manager in Betts (supplier to Pharmaceutical Companies, July 1997-July 1999) and in a number of Clinical Diagnostics companies (September 1983-July 1994) Amersham International, Kodak Clinical Diagnostics, Johnson & Johnson, EURO DPC. I managed validation projects (Installation Qualification, Operational Qualification and Performance Qualification) and the introduction of Projects into the company from customers or from the main site into the company. I managed the company’s quality systems through three FDA inspections, ensured that the company succeeded in ISO9001 audits and that the company met the quality standards required from our customers. At EURO-DPC I recruited and managed 17 staff.

“Scoring for Percutaneous Coronary Intervention (PCI) Events”. Aim to develop a PCI equivalent to Cardiologists’ Euro SCORE. To allow clinicians to report on PCI outcomes adjusted according to patient and procedural risk.

Hidderley M, Holt M. A pilot randomised trial assessing the effects of autogenic training in early stage cancer patients in relation to psychological status and immune system responses. European Journal of Oncology Nursing 2004, 8(1): 61-65.


Martin P Holt’s Publications

AJ Southern Derbyshire Acute Hospitals Trust

Harrop J, Donnely R, Rowbottom A, Holt M, Scott AR (2002) Improvements in total mortality and lipid levels after acute myocardial infarction in an English health district (1995-1999), Heart, 87:428-432.

Khan Z, Macdonald C, Wicks AC, Holt MP, Floyd D, Ghosh S, Wright NA, Playford RJ (2002) Use of the “nutriceutical”, bovine colostrums for the treatment of distal colitis. Aliment Pharmacol Ther 16:1917-22.

Khan Z, Simpson EJ, Cole AT, Holt M, Macdonald I, Pye D, Austin A, Freeman JG (2003) esophageal cancer and cachexia: the effect of short-term treatment with thalidomide on weight loss and lean body mass. Aliment Pharmacol Ther 17:677-82.

Skelly RH, Kupfer RM, Metcalfe ME, Allison SP, Holt M, Hull MA, Rawlings J (2002) percutaneous endoscopic gastrostomy (PEG) change in practice since 1988. Journal of Clinical Nutrition, Oct;21(5):389-94.

Thompson R, Choonara I, Hewitt S, Holt M (2003) Age and sex of drivers associated with child pedestrian injuries Journal of Child Health Care 7 (3) 183-189.

Hidderley M, Holt M. A pilot randomised trial assessing the effects of autogenic training in early stage cancer patients in relation to psychological status and immune system responses. European Journal of oncology Nursing 2004, 8(1): 61-65.

BJ Birmingham Clinical Trials Unit

Grimwade D et al, Refinement of cytogenic classification in AML: Determination of prognostic significance of rare recurring chromosomal abnormalities amongst patients entered into the UK MRC AML 10 & 12 Trials. Blood 2002; 100:195a; Abstract 732.

Kottaridis et al, Consolidation of AML Therapy with autograft and allograft procedures does not negate the poor prognostic impact of FLT3 internal tandem duplications: Results from the UK MRC AML 10 & 12 trials. Blood 2002; 100:75a; Abstract 273.

CJ Cardiovascular Sciences Department, Glenfield Hospital, Leicester

Najmul I. Siddiqi, Anthony H. Gershlick, Keith R. Abrams, Martin P. Holt, Amanda Carver: Risk Assessment for percutaneous coronary intervention: the SCoPE (Scoring for Percutaneous Coronary Intervention Events) Project. ACC.08 Abstracts, 28/9/2007, 57th Annual Scientific Session, March 29-April 1, Chicago.

R. Denton-Beaumont, A.S. Banning, M.P. Holt, NI Siddiqi, K.R. Abrams, A.H. Gershlick P661: Scoring of percutaneous coronary intervention events (SCoPE): results of the Delphi-Rand analysis of predictive risk factors for long term outcomes following PCI. European Journal (2009) 30 (Abstract Supplement), 95.

DJ Kelly, NI Siddiqi, M Holt, AH Gershlick: Multivessel percutaneous coronary intervention versus coronary artery bypass surgery: a new meta-analysis incorporating drug-eluting stent trial data. Heart. 2008:94 (Supp II): A5-A145.

Damian J Kelly, Najam I. Siddiqi, Martin Holt, Kamal Chitkara, Anthony H Gershlick. Meta-analysis of percutaneous coronary intervention versus coronary artery bypass surgery: a new analysis incorporating drug-eluting stent data, Journal of American College of Cardiology, March 2009; Issue No. 10: Supplement.

BCS Poster 1209000, 2008 BCS Scientific Conference: Damian J Kelly, Najam I Siddiqi, Martin Holt, Anthony H Gershlick: Multivessel percutaneous coronary intervention versus coronary artery bypass surgery: a new meta-analysis incorporating drug-eluting stent trial data.

BCS Poster: 1412389, BCS Annual Conference and Exhibition (ACE) 2009 (not accepted): Denton-Beaumont RN: Results from cardiovascular Delphi-Rand Study match meta-analytic summary of published literature well. Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; *Department of Health Sciences, University of Leicester, Leicester, UK.

QUALIFICATIONS / EDUCATION:

Leicester University and de Montfort University, 2001
Advanced MSc in Medical Statistics and Information Technology
Distinction in Summer Project

Open University, 1996
M101 Foundation Course in Mathematics: scored 88%

Bristol University, 1983
BSc (Hons) Biochemistry 2:1

A ‘Levels- Biology, Physics, Chemistry all at Grade A

12 G.C.E O’Levels – 9 at Grade A including 8th in country in GCE Latin.

Special Level 1 Chemistry- Distinction and Biology- Merit.

HOBBIES/INTERESTS

I am a Parish Councilor to Bagworth and Thornton Paris Council. I am a governor at my son’s academies. I am a Fellow of the Royal Statistical Society. I enjoy rambling, photography and eating out with my family. I have a wide taste in music, from my father’s generation to keeping up with my sons.

Areas of Research / Professional Expertise

    Up to 2000, over a period of 17 years, I was permanently employed, full time, working in quality management (QA, QC, validation, new products). I was instrumental in taking 2 companies through FDA inspections. I graduated and gained an Advanced Medical Statistics and Information Technology  MSc in September 2000 (distinction in the 3 month dissertation) and have worked freelance from July 2005 making use of this relatively rare skill-set: Freelance Medical Statistician and Quality Expert. My maxim is "Persistence and Determination Alone are Omnipotent". This combines with a refusal to give in on any particular problem; rather I enjoy problem-solving (I joined MENSA for its puzzles). I am currently near the end of co-authoring an Encyclopoedia of Medical Statistics.

Personal Interests

    The lyrics of music. Rambling. Chess and Bridge. Aquatics. Cake baking

Books

Featured Title
 Featured Title - Concise Encyclopedia of Biostatistics for Med Prof - 1st Edition book cover

Articles

Blood. 2010 Jul 22;116(3):354-65. doi: 10.1182/blood-2009-11-254441. Epub 2010 Apr 12.

Refinement of cytogenetic classification in acute myeloid leukemia: determinatio


Published: Jul 22, 2010 by Blood. 2010 Jul 22;116(3):354-65. doi: 10.1182/blood-2009-11-254441. Epub 2010 Apr 12.
Authors: Grimwade D1, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Can

These data allow more reliable prediction of outcome for patients with rarer abnormalities and may facilitate the development of consensus in reporting of karyotypic information in clinical trials involving younger adults with AML

BCS Poster: 1412389, BCS Annual Conference and Exhibition (ACE) 2009

Results from cardiovascular Delphi-Rand Study match meta-analytic summary of pub


Published: Mar 31, 2009 by BCS Poster: 1412389, BCS Annual Conference and Exhibition (ACE) 2009
Authors: Denton-Beaumont RN

Not Accepted

Journal of American College of Cardiology, March 2009; Issue No. 10: Supplement

Meta-analysis of percutaneous coronary intervention versus coronary artery


Published: Mar 30, 2009 by Journal of American College of Cardiology, March 2009; Issue No. 10: Supplement
Authors: Kelly DJ, Siddiqi NI, Holt MP, Chitkara K, Gershlick AH

incorporating the drug-eluting stent data made for very interesting results

Heart 2008:94(Supp II): A5-A145

Multivessel percutaneous coronary intervention versus coronary artery bypass su


Published: Jan 01, 2009 by Heart 2008:94(Supp II): A5-A145
Authors: Kelly D.J. Siddiqi N.I. Holt M. Gershlik A.H

The work showed promise in the use of drug-eluting stents

THE EUROPEAN JOURNAL OF MEDICINE 30:95

Scoring of percutaneous coronary intervention events (SCoPE): results of the Del


Published: Jan 01, 2009 by THE EUROPEAN JOURNAL OF MEDICINE 30:95
Authors: Denton-Beaumont, Banning AS, Holt MP, Siddiqi NI, Abrams KR, Gershlick AH

The work showed how well the Delphi-Rand method can be used.

BCS Poster 1209000, 2008  BCS Scientific Conference

Multivessel percutaneous coronary intervention versus coronary bypass surgery: a


Published: Mar 30, 2008 by BCS Poster 1209000, 2008 BCS Scientific Conference
Authors: Kelly DJ, Siddiqi NI, Holt M, Gershlick AH

A companion poster to the article published in the Journal of American College of Cardiology

ACC.08  Abstracts, 57th Annual Scientific Session

Risk Assessment for Percutaneous Coronary Intervention: the SCoPE


Published: Sep 28, 2007 by ACC.08 Abstracts, 57th Annual Scientific Session
Authors: Siddiqi NI, Gershlick AH, Abrams KR, Holt MP, Carver A

The abstracts illustrated how well SCoPE works

Eur J Oncol Nurs. 2004 Mar;8(1):61-5.

A pilot randomized trial assessing the effects of autogenic training in early st


Published: Mar 30, 2004 by Eur J Oncol Nurs. 2004 Mar;8(1):61-5.
Authors: Hidderley M, Holt M.

The women receiving AT showed a strong statistical difference for an improvement in their HADS scores and those women observed in a meditative state as opposed to a relaxed state were found to have an increase in their immune responses

J Child Health Care. 2003 Sep;7(3):184-90.

Age and sex of drivers associated with child pedestrian injuries.


Published: Sep 30, 2003 by J Child Health Care. 2003 Sep;7(3):184-90.
Authors: Thompson R1, Choonara I, Hewitt S, Holt M; Derbyshire Road Safety Partnership.

Educational publicity campaigns to reduce driver speeds in urban areas need to be targeted at those drivers most likely to be involved in an RTC with a child.

Aliment Pharmacol Ther. 2003 Mar 1;17(5):677-82.

Oesophageal cancer and cachexia: the effect of short-term treatment with thalido


Published: Mar 01, 2003 by Aliment Pharmacol Ther. 2003 Mar 1;17(5):677-82.
Authors: Khan ZH1, Simpson EJ, Cole AT, Holt M, MacDonald I, Pye D, Austin A, Freeman JG

Thalidomide treatment appeared to reverse the loss of weight and lean body mass over the 2-week trial period.

Oncolink's ASH Coverage

Consolidation of AML Therapy with Autograft and Allograft Procedures Does not


Published: Dec 09, 2002 by Oncolink's ASH Coverage
Authors: Panagiotis D. Kottaridis

Although FLT-3 confers a poor prognosis to adult AML, more intensive upfront therapy for these patients is not the answer.

Aliment Pharmacol Ther. 2002 Nov;16(11):1917-22.

Use of the 'nutriceutical', bovine colostrum, for the treatment of distal coliti


Published: Nov 01, 2002 by Aliment Pharmacol Ther. 2002 Nov;16(11):1917-22.
Authors: Khan Z1, Macdonald C, Wicks AC, Holt MP, Floyd D, Ghosh S, Wright NA, Playford RJ

Bovine colostrum enema shows potential as a novel therapy for left-sided colitis with additional benefits over using mesalazine alone. Further studies appear to be warranted

Clin Nutr. 2002 Oct;21(5):389-94.

Percutaneous endoscopic gastrostomy (PEG): change in practice since 1988.


Published: Oct 30, 2002 by Clin Nutr. 2002 Oct;21(5):389-94.
Authors: Skelly RH1, Kupfer RM, Metcalfe ME, Allison SP, Holt M, Hull MA, Rawlings JK.

30-day mortality was increased from 8% to 19% between 1988-92 and 1998-99 reflecting a change in referral patterns: more elderly with cerebrovascular disease and fewer with motor neurone disease.

Heart 2002 May;87(5):428-31

Improvements in total mortality and lipid levels after acute MI


Published: May 30, 2002 by Heart 2002 May;87(5):428-31
Authors: Harrop J, Donnely R, Rowbottom A, Holt M, Scott AR

1995-1999, there was a significant year on year decline in mortality after admission for acute myocardial infarction.